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40,447 results
  • A Novel Mouse Model of MYO7A USH1B Reveals Auditory and Visual System Haploinsufficiencies. [Journal Article]
    Front Neurosci 2019; 13:1255Calabro KR, Boye SL, … Boye SE
  • Usher's syndrome is the most common combined blindness-deafness disorder with USH1B, caused by mutations in MYO7A, resulting in the most severe phenotype. The existence of numerous, naturally occurring shaker1 mice harboring variable MYO7A mutations on different genetic backgrounds has complicated the characterization of MYO7A knockout (KO) and heterozygote mice. We generated a novel MYO7A KO mou…
  • Advanced noise-induced deafness among workers in singapore - what has changed? [Journal Article]
    Noise Health 2018 Nov-Dec; 20(97):217-222Lim J
  • CONCLUSIONS: NID(A) case profiles have shifted over time, with reduced case numbers, lower hearing loss levels at diagnosis, and earlier case notification, possibly linked to improvements in legislative coverage and NID prevention programs. Changes in age and average duration of noise exposure may be related to these improvements. Early case notification, PPE compliance, and proper usage should be focus areas for NID prevention and hearing conservation programs.
  • Qualification of unilateral cochlear implant recipients for a second device. [Journal Article]
    Otolaryngol Pol 2019; 73(6):8-17Drela M, Haber K, … Mierzwiński J
  • CONCLUSIONS: During evaluation according to the protocol presented in our study, 38% of children with a single cochlear implant were qualified for the second implantation with a chance for an optimal development and effective use of the second cochlear implant. We are convinced that sequential implantation with a short interval between surgeries and with an examination of the vestibular organ, hearing and speech development as well as an assessment of potential benefits from the second implant (bimodal stimulation) before the second implantation is the safest and most beneficial solution for children with severe hearing loss.
    Acta Clin Croat 2019; 58(2):348-353Pegan A, Ries M, … Trotić R
  • The Vibrant Soundbridge represents a new approach to hearing improvement in the form of active implantable middle ear hearing device. Unlike conventional acoustic hearing aids, which increase the volume of sound that goes to the eardrum, the Vibrant Soundbridge bypasses the ear canal and eardrum by directly vibrating the small bones in the middle ear. Because of its design, no portion of the devi…
  • Cochlear Implant Data Logs Predict Children's Receptive Vocabulary. [Journal Article]
    Ear Hear 2019Busch T, Vermeulen A, … van Wieringen A
  • CONCLUSIONS: The results emphasize the importance of consistent CI use and a rich auditory environment for the early language development of young CI users. The study also shows that CI data logs capture information about children's environment and CI use that are related to language performance and can help to detect and address problems and improve the auditory rehabilitation after cochlear implantation.
  • Dual-AAV delivery of large gene sequences to the inner ear. [Review]
    Hear Res 2019; :107857Reisinger E
  • Adeno-associated viruses (AAVs) are preferred vectors for gene replacement therapy, as they are non-pathogenic, non-inflammatory, induce stable transgene expression in terminally differentiated cells, and a series of natural and engineered capsid proteins can be employed to target the vectors to specific cells. Only one feature of AAVs is limiting: the low cargo capacity for foreign DNA, restrict…
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