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836,691 results
  • The Mitochondrial Protein MAVS Stabilizes p53 to Suppress Tumorigenesis. [Journal Article]
    Cell Rep 2020; 30(3):725-738.e4Zhang W, Gong J, … Wei C
  • Recent reports have shown the critical role of the mitochondrial antiviral signaling (MAVS) protein in virus-induced apoptosis, but the involvement of MAVS in tumorigenesis is still poorly understood. Herein, we report that MAVS is a key regulator of p53 activation and is critical for protecting against tumorigenesis. We find that MAVS promotes p53-dependent cell death in response to DNA damage. …
  • Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. [Journal Article]
    Cell Rep 2020; 30(3):699-713.e4Muendlein HI, Sarhan J, … Poltorak A
  • Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activation of MAPK signaling. However, the regulatory mechanisms underlying this kinase-dependent cytokine production remain poorly understood. In the present study…
  • Expression of estrogen receptor α variants and c-Fos in rat mammary gland and tumors. [Journal Article]
    J Steroid Biochem Mol Biol 2020; :105594Gutiérrez A, Sambuco L, … Randi A
  • Breast cancer is currently the leading cause of cancer death among women worldwide. AP-1 (c-Fos/c-Jun) is associated with proliferation and survival, while cytoplasmic c-Fos activates phospholipid synthesis in cells induced to differentiate or grow. Estrogen receptor α 46 (ERα46) is a splice variant of full-length ERα66 and it is known that it has an inhibitory role in cancer cell growth. We inve…
  • Stillbirth Among Arab Women in Canada, 1981-2015. [Journal Article]
    Public Health Rep 2020; :33354919900894Auger N, Racape J, … Janevic T
  • CONCLUSIONS: Arabic-speaking women from Arab countries have higher risks of stillbirth compared with the French and English majority in Quebec. Strategies to reduce stillbirth risk among Arabic speakers should focus on improving identification of causes of death.
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