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74,621 results
  • Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. [Journal Article]
    Cell Syst. 2020 Jun 24 [Online ahead of print]Morinishi L, Kochanowski K, … Altschuler SJ
  • A persistent puzzle in cancer biology is how mutations, which neither alter growth signaling pathways nor directly interfere with drug mechanism, can still recur and persist in tumors. One example is the mutation of the DNA demethylase tet methylcytosine dioxygenase 2 (TET2) in acute myeloid leukemias (AMLs) that frequently persists from diagnosis through remission and relapse, but whose fitness …
  • Geometric quantum discord of Heisenberg model with dissipative terms. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10817.Liang J, Zhang C
  • In this paper, we study a system with two interacting qubits described by the Heisenberg model with dissipative terms, and analyze decay dynamics and the steady-state of geometric quantum discords. Our results indicate that we can ignore the interaction force in the z-direction and adjust the parameters to change the loss of quantum correlation with time when the initial state satisfies some cond…
  • Premature termination codons in the DMD gene cause reduced local mRNA synthesis. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 Jul 02 [Online ahead of print]García-Rodríguez R, Hiller M, … Spitali P
  • Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to the presence of premature termination codons (PTC). Previous transcriptional studies have shown reduced DMD transcript levels in DMD patient and animal model muscles when PTC are present. Nonsense-mediated decay (NMD) has been suggested to be responsible for the observed reduction, but there is no experimental evi…
  • Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum. [Journal Article]
    Genes Dev. 2020 Jul 02 [Online ahead of print]Longman D, Jackson-Jones KA, … Cáceres JF
  • Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic reticulum (ER). Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs. We previously identified NBAS, a component of the Syntaxin 18 complex involved in Golgi-to-ER tra…
  • Poison exons in neurodevelopment and disease. [Review]
    Curr Opin Genet Dev. 2020 Jun 29; 65:98-102.Carvill GL, Mefford HC
  • Poison exons are naturally occurring, highly conserved alternative exons that contain a premature termination codon. Inclusion of a poison exon in a transcript targets the transcript for nonsense mediated decay, decreasing the amount of protein produced. Poison exons are proposed to play an important role in tissue-specific expression, development and autoregulation of gene expression. Recently, …
  • Competitive effects in bacterial mRNA decay. [Journal Article]
    J Theor Biol. 2020 Jun 29 [Online ahead of print]Etienne TA, Cocaign-Bousquet M, Ropers D
  • In living organisms, the same enzyme catalyses the degradation of thousands of different mRNAs, but the possible influence of competing substrates has been largely ignored so far. We develop a simple mechanistic model of the coupled degradation of all cell mRNAs using the total quasi-steady-state approximation of the Michaelis-Menten framework. Numerical simulations of the model using carefully c…
  • Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei. [Journal Article]
    Nucleic Acids Res. 2020 Jul 02 [Online ahead of print]Aphasizheva I, Yu T, … Aphasizhev R
  • In Trypanosoma brucei, mitochondrial pre-mRNAs undergo 3'-5' exonucleolytic processing, 3' adenylation and uridylation, 5' pyrophosphate removal, and, often, U-insertion/deletion editing. The 3' modifications are modulated by pentatricopeptide repeat (PPR) Kinetoplast Polyadenylation Factors (KPAFs). We have shown that KPAF3 binding to the 3' region stabilizes properly trimmed transcripts and sti…
  • Dual plasmonic nanostructures for switching polarity of hot electron-induced photocurrent. [Journal Article]
    Nanoscale. 2020 Jul 02 [Online ahead of print]Hu T, Wu J, … Wang Z
  • We report on the experimental investigation of polarity-switchable hot electron-induced photocurrents in dual-plasmonic nanostructures, consisting of two layers of gold nanoparticles (AuNPs) separated by a TiO2 film. Hot electrons generated through the non-radiative decay of the localized surface plasmon resonances supported by the top and bottom layers of AuNPs can be simultaneously injected int…
  • The emerging roles of N6-methyladenosine RNA methylation in human cancers. [Review]
    Biomark Res. 2020; 8:24.Shen H, Lan Y, … Xie W
  • N6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addition, m6A also participates in a great number of human physiological processes, ranging from spermatogenesis modulation, response to heat shock, the control of T cell homeostasis to stem c…
  • Chemical gradients in human enamel crystallites. [Journal Article]
    Nature. 2020 Jul; 583(7814):66-71.DeRocher KA, Smeets PJM, … Joester D
  • Dental enamel is a principal component of teeth1, and has evolved to bear large chewing forces, resist mechanical fatigue and withstand wear over decades2. Functional impairment and loss of dental enamel, caused by developmental defects or tooth decay (caries), affect health and quality of life, with associated costs to society3. Although the past decade has seen progress in our understanding of …
  • Increasing Temperature and Relative Humidity Accelerates Inactivation of SARS-CoV-2 on Surfaces. [Journal Article]
    mSphere. 2020 Jul 01; 5(4)Biryukov J, Boydston JA, … Altamura LA
  • Coronavirus disease 2019 (COVID-19) was first identified in China in late 2019 and is caused by newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Previous studies had reported the stability of SARS-CoV-2 in cell culture media and deposited onto surfaces under a limited set of environmental conditions. Here, we broadly investigated the effects of relative humidity, tem…
  • Magnetic field-enhanced beam monitor for ionizing radiation. [Journal Article]
    Rev Sci Instrum. 2020 Jun 01; 91(6):063503.Platier B, Limpens R, … Beckers J
  • For the microwave cavity resonance spectroscopy based non-destructive beam monitor for ionizing radiation, an addition-which adapts the approach to conditions where only little ionization takes place due to, e.g., small ionization cross sections, low gas pressures, and low photon fluxes-is presented and demonstrated. In this experiment, a magnetic field with a strength of 57 ± 1 mT was used to ex…
  • Temporary anions of the dielectric gas C3F7CN and their decay channels. [Journal Article]
    J Chem Phys. 2020 Jun 28; 152(24):244304.Ranković M, Kumar T P R, … Fedor J
  • We probe the transient anion states (resonances) in the dielectric gas C4F7N by the electron energy loss spectroscopy and the dissociative electron attachment spectroscopy. The vibrationally inelastic electron scattering leads to two excitation types. The first is the excitation of specific vibrational modes that are assigned with the help of an infrared spectrum of this molecule and quantum chem…
  • Delocalization effects in singlet fission: Comparing models with two and three interacting molecules. [Journal Article]
    J Chem Phys. 2020 Jun 28; 152(24):244125.Accomasso D, Granucci G, … Persico M
  • We present surface hopping simulations of singlet fission in 2,5-bis(fluorene-9-ylidene)-2,5-dihydrothiophene (ThBF). In particular, we performed simulations based on quantum mechanics/molecular mechanics (QM/MM) schemes in which either two or three ThBF molecules are inserted in the QM region and embedded in their MM crystal environment. Our aim was to investigate the changes in the photodynamic…
  • Long memory effects in excitonic systems dynamics: Spectral relations and excitation transport. [Journal Article]
    J Chem Phys. 2020 Jun 28; 152(24):244114.Korsakas S, Bučinskas J, Abramavicius D
  • The main quantity that controls excitation relaxation and transport in molecular systems is the environment-induced fluctuation correlation function. Commonly used models assume the exponentially decaying correlation function, characterized by a given characteristic time, which allows us to define the Markovian conditions and, hence, allows us to use rate equations for excitation dynamics. A long…
  • Constrained pupil balance compensation for specific lithographic illuminator settings. [Journal Article]
    Appl Opt. 2020 Jul 01; 59(19):5837-5844.Rui D, Yang H
  • Pupil energy balances have always been considered significant elements for emersion lithography generally due to the large angle of incidence and offset imaging field. Those imbalances impact on exposure uniformity and decay pattern resolution. To overcome such shortcomings, a study on pupil compensation is discussed in this manuscript. A computational method based on a constrained optimization s…
  • Nonnegative Blind Source Separation for Ill-Conditioned Mixtures via John Ellipsoid. [Journal Article]
    IEEE Trans Neural Netw Learn Syst. 2020 Jul 01; PPLin CH, Bioucas-Dias JM
  • Nonnegative blind source separation (nBSS) is often a challenging inverse problem, namely, when the mixing system is ill-conditioned. In this work, we focus on an important nBSS instance, known as hyperspectral unmixing (HU) in remote sensing. HU is a matrix factorization problem aimed at factoring the so-called endmember matrix, holding the material hyperspectral signatures, and the abundance ma…
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