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7,943 results
  • The interplay between thyroid hormones and the placenta: a comprehensive review. [Journal Article]
    Biol Reprod 2019Adu-Gyamfi EA, Wang YX, Ding YB
  • Thyroid hormones regulate a number of metabolic processes during pregnancy. After implantation, the placenta forms and enhances embryonic growth and development. Dysregulated maternal thyroid hormone signaling has been observed in mal-placentation-mediated pregnancy complications like preeclampsia, miscarriage and intrauterine growth restriction, but the molecular mechanisms involved in this asso…
  • Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection. [Review]
    Front Immunol 2019; 10:1397Jabrane-Ferrat N
  • The hallmark of human early pregnancy is the accumulation of a unique population of Natural Killer (dNK) cells at the main maternal-fetal interface, the decidua basalis. dNK cells play a crucial role in successful placentation probably by orchestrating the invasion of trophoblast cells deep into the decidua basalis and remodeling of the maternal spiral arteries. Recent advances in the field empha…
  • Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia. [Review]
    Int J Mol Sci 2019; 20(15)Vishnyakova P, Elchaninov A, … Sukhikh G
  • The proper functioning of the monocyte-macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte-macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial ges…
  • Fetal fibronectin testing for reducing the risk of preterm birth. [Review]
    Cochrane Database Syst Rev 2019; 7:CD006843Berghella V, Saccone G
  • CONCLUSIONS: The evidence from this review suggests that management based on knowledge of FFN results may reduce preterm birth before 37 weeks. However, our confidence in this result is limited as the evidence was found to be of low quality. Effects on other substantive outcomes are uncertain due to serious concerns in study design, inconsistency, and imprecision of effect estimates. No trials were identified on asymptomatic women, or multiple gestations.Future studies are needed that include specific populations (e.g. singleton gestations with symptoms of preterm labor), a study group managed with a protocol based on the FFN results, and that report not only maternal but also important perinatal outcomes. Cost-effectiveness analyses are also needed.
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