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8,023 results
  • The role of CXC chemokine ligand 16 in physiological and pathological pregnancies. [Review]
    Am J Reprod Immunol 2020Shi JW, Yang HL, … Li MQ
  • The survival and development of a semi-allogeneic fetus during pregnancy requires the involvement of a series of cytokines and immune cells. Chemokines are a type of special cytokine that were originally described as having a role in leukocyte trafficking. CXC chemokine ligand (CXCL) 16 is a member of the chemokine family, and CXC chemokine receptor (CXCR) 6 is its sole receptor. Emerging evidenc…
  • Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy. [Journal Article]
    Nat Commun 2020; 11(1):381Huhn O, Ivarsson MA, … Colucci F
  • During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets: decidual NK cells (dNK)1-3, ILC3s and proliferating NK cells. Following stimulation, dNK2 and dNK3 produce more chemokines than dNK1 including XCL1 which can act on both mater…
  • The Unique Microbiome and Innate Immunity During Pregnancy. [Review]
    Front Immunol 2019; 10:2886Mei C, Yang W, … Huang D
  • A successful pregnancy depends on not only the tolerance of the fetal immune system by the mother but also resistance against the threat of hazardous microorganisms. Infection with pathogenic microorganisms during pregnancy may lead to premature delivery, miscarriage, growth restriction, neonatal morbidity, and other adverse outcomes. Moreover, the host also has an intact immune system to avoid t…
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