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10,076 results
  • Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease. [Journal Article]
    Aging Dis 2019; 10(4):684-698Maeso-Díaz R, Ortega-Ribera M, … Gracia-Sancho J
  • Advanced chronic liver disease (aCLD) represents a major public health concern. aCLD is more prevalent and severe in the elderly, carrying a higher risk of decompensation. We aimed at understanding how aging may impact on the pathophysiology of aCLD in aged rats and humans and secondly, at evaluating simvastatin as a therapeutic option in aged animals. aCLD was induced in young (1 month) and old …
  • An Innovative Platform to Analyze Heart Failure Biomarkers in Saliva. [Journal Article]
    Stud Health Technol Inform 2019; 264:1724-1725Martínez-García A, García-Ocaña P, … Parra-Calderón CL
  • This paper explains a methodology to improve patient safety through early detecting of HF complications and analyzing HF biomarkers in saliva obtained using a biosensor developed in HEARTEN project. A pilot study was performed in two hospitals in Spain and Italy respectively. A direct correlation was identified between TNF-alpha levels in saliva and weight. The weight gain in HF patients could pr…
  • [Bipolar disorder vulnerability: The vitamin D path]. [Journal Article]
    Can J Psychiatry 2019; :706743719870513Manel N, Manel MB, … Fatma A
  • CONCLUSIONS: Our study shows that BD acute decompensation is associated with the rise in plasma 25OHD synthesis. However, the vitamin D dosage relevance as a biomarker of this disease warrants a verification in other studies.
  • The multifaceted nature of diabetes mellitus induced by checkpoint inhibitors. [Journal Article]
    Acta Diabetol 2019Marchand L, Disse E, … Cugnet-Anceau C
  • Immune checkpoint inhibitors (CPI) are increasingly being used in oncology, and many autoimmune side effects have been described. Diabetes mellitus (DM) has been reported in approximately 1% of subjects treated with programmed cell death-1 and programmed death ligand 1 (PD-1/PD-L1) inhibitors, alone or in association with CTLA-4 inhibitors. In the present mini-review, we aimed to describe differe…
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