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229,271 results
  • A simple POM clusters for in vivo NIR-II photoacoustic imaging-guided NIR-II photothermal therapy. [Journal Article]
    J Inorg Biochem. 2020 May 26; 209:111121.Han Y, Qu B, … Zhang R
  • Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window exhibits enhanced deep-tissue imaging capability. Likely, cancer therapy in the NIR-II window could provide deeper penetration depth and higher exposure to laser over NIR-I. However, the traditional application of excitation light is still in the NIR-I window. In view of the excellent imaging and therapeutic capabilities of NI…
  • Initializing photonic feed-forward neural networks using auxiliary tasks. [Journal Article]
    Neural Netw. 2020 Jun 01; 129:103-108.Passalis N, Mourgias-Alexandris G, … Tefas A
  • Photonics is among the most promising emerging technologies for providing fast and energy-efficient Deep Learning (DL) implementations. Despite their advantages, these photonic DL accelerators also come with certain important limitations. For example, the majority of existing photonic accelerators do not currently support many of the activation functions that are commonly used in DL, such as the …
  • DeepDTI: High-fidelity six-direction diffusion tensor imaging using deep learning. [Journal Article]
    Neuroimage. 2020 Jun 03 [Online ahead of print]Tian Q, Bilgic B, … Huang SY
  • Diffusion tensor magnetic resonance imaging (DTI) is unsurpassed in its ability to map tissue microstructure and structural connectivity in the living human brain. Nonetheless, the angular sampling requirement for DTI leads to long scan times and poses a critical barrier to performing high-quality DTI in routine clinical practice and large-scale research studies. In this work we present a new pro…
  • Radiomics for precision medicine: current challenges,future prospects, and the proposal of a new framework. [Review]
    Methods. 2020 Jun 03 [Online ahead of print]Ibrahim A, Primakov S, … Lambin P
  • The advancement of artificial intelligence concurrent with the development of medical imaging techniques provided a unique opportunity to turn medical imaging from mostly qualitative, to further quantitative and mineable data that can be explored for the development of clinical decision support systems (cDSS). Radiomics, a method for the high throughput extraction of hand-crafted features from me…
  • Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis. [Journal Article]
    Cancer Lett. 2020 Jun 03 [Online ahead of print]Chaves de Almeida Bastos D, Weinberg J, … Prabhu SS
  • Stereotactic Radiosurgery has become the main treatment for patients with limited number of brain metastases (BM). Recently, with the increasing use of this modality, there is a growth in recurrence cases. Recurrence after radiation therapy can be divided in changes favoring either tumor recurrence or radiation necrosis (RN). Laser Interstitial Thermal Therapy (LITT) is minimally invasive treatme…
  • Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities. [Review]
    J Neurooncol. 2020 Jun 05 [Online ahead of print]Sun Y, Bailey CP, … Chandra J
  • CONCLUSIONS: The genetic and phenotypic diversity of pHGGs is now well characterized after large-scale sequencing studies on patient tissue. However, clinical treatment paradigms have not yet shifted in response to this information. Combination therapies targeting multiple kinases or epigenetic targets may hold more promise, especially if attempted in selected patient populations with hemispheric pHGG tumors and relevant targeted therapeutic biomarkers.
  • Automated lung cancer diagnosis using three-dimensional convolutional neural networks. [Journal Article]
    Med Biol Eng Comput. 2020 Jun 05 [Online ahead of print]Perez G, Arbelaez P
  • Lung cancer is the deadliest cancer worldwide. It has been shown that early detection using low-dose computer tomography (LDCT) scans can reduce deaths caused by this disease. We present a general framework for the detection of lung cancer in chest LDCT images. Our method consists of a nodule detector trained on the LIDC-IDRI dataset followed by a cancer predictor trained on the Kaggle DSB 2017 d…
  • Interactions of Hematopoietic Stem Cells with Bone Marrow Niche. [Journal Article]
    Methods Mol Biol. 2020 Jun 06 [Online ahead of print]Zhao X, Zhang C, … Liang Y
  • Hematopoietic stem cells (HSCs) are ultimately responsible for the lifelong renewal of all blood cell lineages. In the bone marrow (BM), HSCs reside in specialized microenvironments referred to as the "niche." HSC niche consists of complex components including heterogeneous cell populations, growth factors, and extracellular matrix molecules. The crosstalk between HSCs and their niche is essentia…
  • Penetrating glassy carbon neural electrode arrays for brain-machine interfaces. [Journal Article]
    Biomed Microdevices. 2020 Jun 06; 22(3):43.Chen B, Zhang B, … Cheng MM
  • This paper presents a fabrication method for glassy carbon neural electrode arrays that combines 3D printing and chemical pyrolysis technology. The carbon electrodes have excellent biological compatibility and can be used in neural signal recording. A pretreated Si wafer is used as the substrate for 3D printing, and then, stereolithography 3D printing technology is employed to print photosensitiv…
  • The basics of data, big data, and machine learning in clinical practice. [Review]
    Clin Rheumatol. 2020 Jun 05 [Online ahead of print]Soriano-Valdez D, Pelaez-Ballestas I, … Gastelum-Strozzi A
  • Health informatics and biomedical computing have introduced the use of computer methods to analyze clinical information and provide tools to assist clinicians during the diagnosis and treatment of diverse clinical conditions. With the amount of information that can be obtained in the healthcare setting, new methods to acquire, organize, and analyze the data are being developed each day, including…
  • The medial ligaments and the ACL restrain anteromedial laxity of the knee. [Journal Article]
    Knee Surg Sports Traumatol Arthrosc. 2020 Jun 05 [Online ahead of print]Ball S, Stephen JM, … Amis AA
  • CONCLUSIONS: The dMCL is the largest medial restraint to tibial external rotation in extension. Therefore, following a combined ACL + MCL injury, AMRI may persist if there is inadequate healing of both the sMCL and dMCL, and MCL deficiency increases the risk of ACL graft failure.
  • [Increased risk of deep vein thrombosis in intensive care unit patients with CoViD-19 infections?-Preliminary data]. [Journal Article]
    Chirurg. 2020 Jun 05 [Online ahead of print]Zerwes S, Hernandez Cancino F, … Hyhlik-Dürr A
  • CONCLUSIONS: We recommend the determination of D‑dimer levels and, in the case of elevated levels, the broad indication for compression sonography of the deep leg veins on admission of patients with suspected or confirmed SARS-CoV2. In this way DVT in the setting of CoViD-19 can be recognized early and therapeutic anticoagulation can be started. All inpatient CoViD-19 patients should receive thrombosis prophylaxis with low molecular weight heparin. Further studies on point of care methods (TEG®, ROTEM®) for the detection of hypercoagulability in SARS-CoV2 are necessary.
  • Pulmonary Embolism: A Practical Guide for the Busy Clinician. [Review]
    Heart Fail Clin. 2020 Jul; 16(3):317-330.Demelo-Rodriguez P, Galeano-Valle F, … Marra AM
  • Acute pulmonary embolism (PE) is the third most common acute cardiovascular condition, and its prevalence increases over time. D-dimer has a very high negative predictive value, and if normal levels of D-dimer are detected, the diagnosis of PE is very unlikely. The final diagnosis should be confirmed by computed tomographic scan. However, echocardiography is the most available, bedside, low-cost,…
  • Local Anesthetic Facelift. [Review]
    Facial Plast Surg Clin North Am. 2020 Aug; 28(3):409-418.DeJoseph LM, Pou JD
  • A thorough medical history is critical in patient selection for local anesthesia facelifting. Patients with no prior issues with dental procedures and no history of significant anxiety are better candidates. Simplifying local anesthesia mixtures and using dilute concentrations will minimize dosing errors and decrease risk of local anesthesia toxicity. Oral anxiolytics can be used with caution to …
  • From the Deep-Plane Rhytidectomy to the Vertical Platysma Advancement. [Review]
    Facial Plast Surg Clin North Am. 2020 Aug; 28(3):311-330.Gordon NA, Tower JI, Paskhover B
  • This article provides the facial plastic surgeon with anatomic and embryologic evidence supporting use of the deep-plane technique and understanding the evolution of the technique over decades to the vertical platysma advancement for optimal treatment of facial aging. The original description of the deep-plane rhytidectomy described a basic subsuperficial musculoaponeurotic system dissection in t…
  • Extended Superficial Musculoaponeurotic System Flap Rhytidectomy. [Review]
    Facial Plast Surg Clin North Am. 2020 Aug; 28(3):303-310.Quatela V, Montague A, … Antunes M
  • The various rhytidectomy techniques share a common goal of safe repositioning of the facial soft tissues with a lasting effect. This article reviews rhytidectomy approaches and the current methods and practice patterns of the senior author. It includes a discussion of the extended sub-superficial musculoaponeurotic system rhytidectomy technique, which, in the opinion of the senior author, offers …
  • Nuances in Superficial Musculoaponeurotic System Rhytidectomy. [Review]
    Facial Plast Surg Clin North Am. 2020 Aug; 28(3):285-301.Rousso DE, Adams AS
  • Rhytidectomy techniques have evolved since the early 1900s. As the understanding of facial anatomy and the aging process expanded, the superficial musculoaponeurotic system (SMAS) became a focal point in developing longer-lasting, natural results. Further evolution led to various approaches in repositioning the SMAS layer, including subperiosteal, composite, and deep plane rhytidectomies. This ar…
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