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7,982 results
  • A general concept for the introduction of hydroxamic acids into polymers. [Journal Article]
    Chem Sci 2019; 10(29):7009-7022Johann T, Keth J, … Frey H
  • Hydroxamic acids (HA) form stable complexes with a large variety of metal-ions, affording hydroxamates with high complexation constants. Hydroxamic acid moieties play a crucial role in the natural iron metabolism. In this work, 1,4,2-dioxazoles linked to a hydroxyl group are introduced as key compounds for the installation of hydroxamic acids at synthetic polymers in well-defined positions. A gen…
  • Clinical and experimental aspects of aneurysmal subarachnoid hemorrhage. [Review]
    CNS Neurosci Ther 2019; 25(10):1096-1112Daou BJ, Koduri S, … Pandey AS
  • Aneurysmal subarachnoid hemorrhage (aSAH) continues to be associated with significant morbidity and mortality despite advances in care and aneurysm treatment strategies. Cerebral vasospasm continues to be a major source of clinical worsening in patients. We intended to review the clinical and experimental aspects of aSAH and identify strategies that are being evaluated for the treatment of vasosp…
  • Quantifying Intranasally Administered Deferoxamine in Rat Brain Tissue with Mass Spectrometry. [Journal Article]
    ACS Chem Neurosci 2019Kosyakovsky J, Witthuhn BA, … Fine JM
  • Deferoxamine, a metal chelator, has been shown to be neuroprotective in animal models of ischemic stroke, traumatic brain injury and both subarachnoid and intracerebral hemorrhage. Intranasal deferoxamine (IN DFO) has also shown promise as a potential treatment for multiple neurodegenerative diseases, including Parkinson's and Alzheimer's. However, there have been no attempts to thoroughly unders…
  • Ferrostatin-1 protects HT-22 cells from oxidative toxicity. [Journal Article]
    Neural Regen Res 2020; 15(3):528-536Chu J, Liu CX, … Li QL
  • Ferroptosis is a type of programmed cell death dependent on iron. It is different from other forms of cell death such as apoptosis, classic necrosis and autophagy. Ferroptosis is involved in many neurodegenerative diseases. The role of ferroptosis in glutamate-induced neuronal toxicity is not fully understood. To test its toxicity, glutamate (1.25-20 mM) was applied to HT-22 cells for 12 to 48 ho…
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