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7,728 results
  • Evaluating single-subject study methods for personal transcriptomic interpretations to advance precision medicine. [Journal Article]
  • BMBMC Med Genomics 2019 Jul 11; 12(Suppl 5):96
  • Rachid Zaim S, Kenost C, … Lussier YA
  • CONCLUSIONS: The "all-against-one" framework provides a honest evaluation framework for single-subject DEG studies since these methods are evaluated, by design, against reference standards produced by unrelated DEG methods. The ss-ensemble method was the only one to reliably produce higher accuracies in all conditions tested in this conservative evaluation framework. However, single-subject methods for identifying DEGs from paired samples need improvement, as no method performed with precision> 90% and obtained moderate levels of recall. http://www.lussiergroup.org/publications/EnsembleBiomarker.
  • Simultaneous optimization of mixed photon energy beams in volumetric modulated arc therapy. [Journal Article]
  • MPMed Phys 2019 Jul 05
  • Momin S, Gräfe J, … Khan R
  • CONCLUSIONS: We demonstrate the first formalism of a large scale simultaneous optimization of mixed photon energy beams for VMAT. Dosimetric comparison of MP - VMAT to single energy VMAT demonstrated potential advantages of using mixed photon energy beams for prostate plans, thus providing an impetus for further testing on a large clinical cohort. This article is protected by copyright. All rights reserved.
  • Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use. [Journal Article]
  • EJEur J Nucl Med Mol Imaging 2019 Jul 01
  • He T, Wang M, … Li Z
  • CONCLUSIONS: We have demonstrated that NTSR1 is a promising molecular marker for prostate cancer based on patient tissue staining. The NTSR targeted probe 18F-DEG-VS-NT demonstrated high tumor to background contrast in animal models, which could be valuable in selecting patients for therapies targeting NTSR1 as well as monitoring therapeutic efficacy during treatment accordingly.
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