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14,586 results
  • Mechanisms and therapeutic targets of ischemic acute kidney injury. [Review]
    Kidney Res Clin Pract 2019Han SJ, Lee HT
  • Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy and is a significant and frequent cause of morbidity and mortality during the perioperative period. Although the pathophysiology of ischemic AKI is not completely understood, several important mechanisms of renal IR-induced AKI have been studied. Renal ischemia and subsequent rep…
  • [The antimicrobial strategies of neutrophils under infection pathology.] [Journal Article]
    Klin Lab Diagn 2016; 61(12):825-833Andryukov BG, Somova LM, … Matosova EV
  • The neutrophilic granulocytes were traditionally considered exclusively as phagocytes - killer cells of microorganisms invaded human organism. The discoveries of last decade permitted to significantly reconsider this role and importance of neutrophils in implementation of affect mechanisms of inherent and adaptive immunity. The modern achievements expanded our conceptions about anti-microbial str…
  • TAM receptors attenuate murine NK cell responses via E3 ubiquitin ligase Cbl-b. [Journal Article]
    Eur J Immunol 2019Chirino LM, Kumar S, … Kambayashi T
  • TAM receptors (Tyro3, Axl, and Mer) are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including natural killer (NK) cells. Although RTKs typically enhance cellular functions, TAM receptor ligation blocks NK cell activation. The mechanisms by which RTKs block NK cell signaling downstream of activating receptors are unknown. In this report, we demonstrate that TAM rec…
  • WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo. [Journal Article]
    Toxicol Appl Pharmacol 2019; :114763Park YH, Kim DK, … Choi WS
  • Mast cells (MCs) play an important role as effector cells that cause allergic responses in allergic diseases. For these reasons, MC is considered an attractive therapeutic target for allergic disease treatment. In this study, we investigated the inhibitory effect of WZ3146, N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide, and the mechanisms of its actio…
  • Magnolin inhibits IgE/Ag-induced allergy in vivo and in vitro. [Journal Article]
    Int Immunopharmacol 2019; 76:105867Ma P, Che D, … He H
  • Mast cells (MCs) play critical roles in allergic reactions and modulating the activation of MCs could be an effective strategy to treat allergic diseases, which cause a rapidly increasing threat to the public health. Herein, we described that Magnolin, a major component from Flos magnoliae could inhibit IgE-dependent MCs activation. We found Magnolin inhibited IgE/Ag-induced calcium mobilization,…
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