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51,456 results
  • Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition. [Journal Article]
    Adv Pharmacol. 2020; 89:43-78.Luscher B, Feng M, Jefferson SJ
  • There has been much recent progress in understanding of the mechanism of ketamine's rapid and enduring antidepressant effects. Here we review recent insights from clinical and preclinical studies, with special emphasis of ketamine-induced changes in GABAergic synaptic transmission that are considered essential for its antidepressant therapeutic effects. Subanesthetic ketamine is now understood to…
  • Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. [Journal Article]
    Cell. 2020 Jun 26 [Online ahead of print]Nguyen PT, Dorman LC, … Molofsky AV
  • Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner and defines a neuronal subset primed for synaptic plas…
  • ERK Regulates NeuroD1-mediated Neurite Outgrowth via Proteasomal Degradation. [Journal Article]
    Exp Neurobiol. 2020 Jul 01 [Online ahead of print]Lee TY, Cho IS, … Suh-Kim H
  • Neurogenic differentiation 1 (NeuroD1) is a class B basic helix-loop-helix (bHLH) transcription factor and regulates differentiation and survival of neuronal and endocrine cells by means of several protein kinases, including extracellular signal-regulated kinase (ERK). However, the effect of phosphorylation on the functions of NeuroD1 by ERK has sparked controversy based on context-dependent diff…
  • Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. [Review]
    Biomolecules. 2020 Jun 26; 10(6)Jossin Y
  • During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway has been associated with several human brain disorders such as lissencephaly, autism, schizophrenia, bipol…
  • Power-efficient neural network with artificial dendrites. [Journal Article]
    Nat Nanotechnol. 2020 Jun 29 [Online ahead of print]Li X, Tang J, … Wu H
  • In the nervous system, dendrites, branches of neurons that transmit signals between synapses and soma, play a critical role in processing functions, such as nonlinear integration of postsynaptic signals. The lack of these critical functions in artificial neural networks compromises their performance, for example in terms of flexibility, energy efficiency and the ability to handle complex tasks. H…
  • NELL2 Function in Axon Development of Hippocampal Neurons. [Journal Article]
    Mol Cells. 2020 Jun 30; 43(6):581-589.Kim HR, Kim DH, … Lee BJ
  • Neurons have multiple dendrites and single axon. This neuronal polarity is gradually established during early processes of neuronal differentiation: generation of multiple neurites (stages 1-2); differentiation (stage 3) and maturation (stages 4-5) of an axon and dendrites. In this study, we demonstrated that the neuron-specific n-glycosylated protein NELL2 is important for neuronal polarization …
  • Identifying interactive biological pathways associated with reading disability. [Journal Article]
    Brain Behav. 2020 Jun 28 [Online ahead of print]Lancaster HS, Liu X, … Li J
  • CONCLUSIONS: The behavioral and demographic factors were suggested to be protective against reading disability status, while birthweight conveyed risk. We provided supporting evidence that reading disability has a complex biological and environmental etiology and that there may be a shared genetic and neurobiological architecture for reading (dis)ability.
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