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82,364 results
  • Effects of sympathetic modulation in metabolic disease. [Review]
    Ann N Y Acad Sci 2019Carnagarin R, Lambert GW, … Schlaich MP
  • Sympathetic overdrive contributes to the derangement of glucose metabolism evident in clinical conditions, such as obesity, metabolic syndrome, type 2 diabetes, obstructive sleep apnea, and others. Targeting the sympathetic nervous system directly therefore appears as an attractive therapeutic approach to restore impaired glucose metabolism. Indeed, lifestyle interventions, including healthier di…
  • Neuroimmune interactions and kidney disease. [Review]
    Kidney Res Clin Pract 2019Hasegawa S, Inoue T, Inagi R
  • The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied neuroimmune interaction involving the vagus nerve. CD4-positive T cells expressing β2 adrenergic receptors and macrophages expressing the alpha 7 subunit of the nicotinic …
  • The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation. [Journal Article]
    Mol Med 2019; 25(1):39Hilderman M, Qureshi AR, … Bruchfeld A
  • CONCLUSIONS: RDN has an immediate effect on TNF in vivo and cytokine release ex vivo but seems to wane over time suggesting that current RDN techniques may not have long-lasting immunomodulatory effect. Repeated and extended stimulation of CAP in resistant hypertension by targeting neural circuits may be a potential therapeutic strategy for treatment of both hypertension and inflammation.
  • Splenic artery denervation: target micro-anatomy, feasibility, and early preclinical experience. [Journal Article]
    Transl Res 2019Albaghdadi M, Garcia-Polite F, … Tzafriri A
  • This study sought to evaluate perisplenic artery nerve distribution and the feasibility of splenic artery denervation (SDN). The NEXION radiofrequency catheter was used to perform SDN in healthy and inflammatory arthritis pigs. Splenic artery anatomy, nerve distribution, and splenic norepinephrine (NEPI) levels were evaluated before and after SDN. Perisplenic artery nerves were primarily distribu…
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