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61 results
  • [Pharmacology of Janus kinase inhibitors]. [Review]
    Hautarzt. 2019 Dec; 70(12):934-941.Solimani F, Hilke FJ, Ghoreschi K
  • Modern dermatotherapy is dominated by the development of various biologicals and small molecules. Janus kinase inhibitors (JAKi) form a novel class of small molecular synthetic compounds inhibiting the intracellular signal transduction of cytokine receptors. Cytokines are key mediators in the pathophysiology of numerous inflammatory skin diseases. Many cytokines use so-called type I and II cytoki…
  • Successful Use of Oral Acyclovir in Ophthalmic Molluscum Contagiosum. [Case Reports]
    Indian Dermatol Online J. 2019 Jul-Aug; 10(4):456-459.Mutalik SD, Rasal YD
  • Molluscum contagiosum is a common tropical contagious viral infection, involving the skin and the mucous membranes. Ophthalmic molluscum contagiosum is a relatively uncommon condition presenting as secondary follicular conjunctivitis or kerato-conjunctivitis and may present with or without obvious dermal skin lesions. Often, unsuspected and misdiagnosed by eye care providers or observed as a conc…
  • Biologic Agents In Systemic Dermatotherapy: Cutaneous And Systemic Side Effects. [Journal Article]
    Curr Drug Saf. 2017 May 18 [Online ahead of print]Badavanis G, Pasmatzi E, … Tsambaos D
  • The recent significant breakthroughs in the understanding of the pathogenetic mechanisms of psoriasis and other immune-mediated inflammatory disorders, have led to the emergence of a wide array of biologic agents or biologics, that are especially designed to target selective intracellular or extracellular components and pathways of the dysregulated immune response. These targeted biologic agents …
  • Dendritic nanoparticles for cutaneous drug delivery--testing in human skin and reconstructed human skin. [Review]
    Curr Pharm Des. 2015; 21(20):2784-800.Zoschke C, Schilrreff P, … Schafer-Korting M
  • Dendritic nanoparticles have been developed with auspicious properties like high loading capacity for guest molecules, low polydispersity and tunable end groups. Demonstrating increased cellular uptake and bypassed efflux transporters, dendritic nanoparticles may offer new treatment options for therapy-resistant diseases. New core-shell architectures address the drawbacks of initial approaches. E…
  • Dermatologic therapy in geriatric patients. [Review]
    J Dtsch Dermatol Ges. 2014 Aug; 12(8):653-63; quiz 664.Kratzsch D, Treudler R
  • Demographic changes in our society will lead to an increasing proportion of elderly people. Age-associated multimorbidity often results in polypharmacy and elevates the risk of adverse drug reactions. Decisive alterations in pharmacokinetics and pharmacodynamics are detectable in old age, primarily a decrease in total body water, an altered ratio of muscle mass to fatty tissue, and decreased rena…
  • Utilization of biodegradable polymeric materials as delivery agents in dermatology. [Review]
    Clin Cosmet Investig Dermatol. 2014; 7:23-34.Rancan F, Blume-Peytavi U, Vogt A
  • Biodegradable polymeric materials are ideal carrier systems for biomedical applications. Features like controlled and sustained delivery, improved drug pharmacokinetics, reduced side effects and safe degradation make the use of these materials very attractive in a lot of medical fields, with dermatology included. A number of studies have shown that particle-based formulations can improve the skin…
  • The other end of the rainbow: infrared and skin. [Comment]
    J Invest Dermatol. 2010 Jun; 130(6):1496-9.Holzer AM, Athar M, Elmets CA
  • Although infrared radiation (IRR) is ubiquitous in the terrestrial milieu, its effects on human skin have until now been largely ignored. Recent studies suggest an important role for infrared A (IRA) radiation (760-1440 nm) in dermal inflammation, photoaging, and photocarcinogenesis. In this issue, Calles et al. identify and analyze the IRA-induced transcriptome in human dermal fibroblasts. Their…
  • Peat: a natural source for dermatocosmetics and dermatotherapeutics. [Journal Article]
    J Cutan Aesthet Surg. 2009 Jan; 2(1):17-20.Wollina U
  • In recent years the interest for natural substances in dermatotherapy and cosmetics has increased. Peat is a complex natural source of humic substances that are of potential interest in both dermatology and cosmetology. Humic substances in peat have been partially characterized and pharmacologic and biologic activities have been documented. Possible clinical applications are outlined.
  • Treatment of keloids and hypertrophic scars. [Review]
    Indian J Dermatol Venereol Leprol. 2005 Jan-Feb; 71(1):3-8.Mutalik S
  • Clinicians always find it difficult to treat hypertrophic scars and keloids. Various treatment modalities are available. Intralesional corticosteroids, topical applications, cryotherapy, surgery, laser therapy, and silicone sheeting are the widely used options. Radiation therapy can also help in cases of recalcitrant keloids. Most recently, pulsed-dye laser has been successfully used to treat kel…
  • Follicular targeting--a promising tool in selective dermatotherapy. [Review]
    J Investig Dermatol Symp Proc. 2005 Dec; 10(3):252-5.Vogt A, Mandt N, … Blume-Peytavi U
  • The penetration of topically applied compounds varies considerably in the different regions of the human body. The presence of hair follicles significantly contributes to this effect by an increase in surface area and a disruption of the epidermal barrier towards the lower parts of the hair follicle. The human hair follicle, hereby, serves not only as a reservoir, but also as a major entry point …
  • [Pediatric dermatotherapy]. [Journal Article]
    Hautarzt. 2003 Jan; 54(1):10-3.Vogel M, Brockow K, Abeck D
  • Dermatological therapy of children differs considerably from treatment of adults and poses a special challenge. Dermatological diseases often form idiosyncratic entities with a prognosis different from adults and must be treated appropriately. Consideration should also be given to the fact that children occasionally experience adverse reactions to drugs, which are not observed in adults. A select…
  • The 500 Dalton rule for the skin penetration of chemical compounds and drugs. [Review]
    Exp Dermatol. 2000 Jun; 9(3):165-9.Bos JD, Meinardi MM
  • Human skin has unique properties of which functioning as a physicochemical barrier is one of the most apparent. The human integument is able to resist the penetration of many molecules. However, especially smaller molecules can surpass transcutaneously. They are able to go by the corneal layer, which is thought to form the main deterrent. We argue that the molecular weight (MW) of a compound must…
  • Surgical management of stable vitiligo: A review with personal experience. [Review]
    Dermatol Surg. 2000 Mar; 26(3):248-54.Mutalik S, Ginzburg A
  • CONCLUSIONS: Although the retrospective nature of this article limits its validity, discussing the various therapeutic options is of value as continuing medical education. Surgical treatment may be individualized to obtain the best possible cosmetic result.
  • The use of systemic antimycotics in dermatotherapy. [Journal Article]
    Eur J Dermatol. 2000 Mar; 10(2):155-60.Niewerth M, Korting HC
  • Fungal infections of the skin as well as of the nails and hair due to dermatophytes or due to yeasts or moulds still form a major portion of skin diseases overall. Effective therapy of mycoses is not always simple to achieve. In less severe cases topical therapy can be sufficient, but in extensive cutaneous infections, previous resistance to treatment and especially hyperkeratotic tinea and onych…
  • [Therapeutic use of lasers in dermatology]. [Review]
    Ther Umsch. 1999 Apr; 56(4):170-5.Hohenleutner U, Wimmershoff MB, … Landthaler M
  • In recent years, lasers have become an indispensable part of dermatotherapy. Multiple lasers allow the treatment of the most contrasting indications. Port wine stains, childhood hemangiomas, telangiectasias as well as other vascular malformations and neoplasms represent the most significant indications for laser therapy. Furthermore, modern lasers are used not only for the removal of non-professi…
  • Interferons in dermatology. Present-day standard. [Review]
    Dermatol Clin. 1998 Apr; 16(2):377-98.Stadler R
  • Since the first clinical trials in the early 1980s with recombinant interferon, it was possible to show for a variety of indications that cytokines, especially interferons, at certain doses and at respective intervals, when applied in combination with other pharmaceutical compounds open new powerful therapeutic possibilities. Worldwide, recombinant interferon is licensed, especially in dermato-on…
  • [Dermatology]. [Historical Article]
    Arzneimittelforschung. 1997 Oct; 47(10):1174-6.Jung EG
  • The dermatotherapy of the past 30 years made enormous progress. It is focused on frequent diseases as acne, atopic dermatitis, psoriasis and mycoses. Research will provide us during the next years with additional therapeutic tools on chronic inflammation and in wound healing.
  • The effect of tamol on human mast cell chymase and plasmin. [Journal Article]
    Skin Pharmacol. 1997; 10(2):90-6.Wiedow O, Weindler F, Mrowietz U
  • Tamol is widely used in the therapy of inflammatory dermatoses. It has pronounced astringent properties and is able to inactivate the neutrophil-derived elastase. Since plasminogen activation and release of mast cell chymase may occur in acute dermatitis, we investigated the inhibitory properties of tamol for these enzymes. Tamol proved to be a potent inhibitor of plasmin and mast cell chymase in…
  • [Group sports as adjuvant therapy for patients with atopic eczema]. [Controlled Clinical Trial]
    Hautarzt. 1994 Nov; 45(11):751-5.Salzer B, Schuch S, … Hornstein OP
  • The therapeutic value of regular physical exercise for patients with atopic eczema (AE) and other chronic inflammatory dermatoses has not yet been investigated systematically. At our institution an adjuvant group sports programme for voluntary inpatients has been in place for 3 years. Using a standardized questionnaire we found positive psychological influences of this program on the patients' mo…
  • [Paths to a rational cortisone therapy via urea supplements--countering cortisone phobia]. [Review]
    Hautarzt. 1992; 43 Suppl 11:23-9.Drosner M
  • Not until corticosteroids came into use did it become possible for modern dermatotherapy to cure numerous skin diseases, and if not cure them, at least rapidly lead to major improvements and the transition to symptom-free intervals. Through indiscriminate use, corticosteroid therapy has become discredited by patient and doctor alike due to the increased incidence of side effects. Due to this inte…
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