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7,815 results
  • Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. [Journal Article]
    Transl Psychiatry 2019; 9(1):222Thompson SL, Welch AC, … Dulawa SC
  • BTB/POZ domain-containing 3 (BTBD3) was identified as a potential risk gene in the first genome-wide association study of obsessive-compulsive disorder (OCD). BTBD3 is a putative transcription factor implicated in dendritic pruning in developing primary sensory cortices. We assessed whether BTBD3 also regulates neural circuit formation within limbic cortico-striato-thalamo-cortical circuits and b…
  • Expression, purification and stabilization of human serotonin transporter from E. coli. [Journal Article]
    Protein Expr Purif 2019; 164:105479Worms D, Maertens B, … Labahn J
  • The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans. It is therefore an important drug target to support treatment of depression. Recently, structures of human serotonin transporter in complex with inhibitor molecules have been published. However, the production of large protein amounts for crystallization …
  • Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-amino-λ6 -sulfanenitrile Intermediate. [Review]
    Angew Chem Int Ed Engl 2019Briggs EL, Tota A, … Bull JA
  • Sulfonimidamides are intriguing new motifs for medicinal and agrochemistry, and provide attractive bioisosteres for sulfonamides. However, there remain few operationally simple methods for their preparation. Here, the synthesis of NH-sulfonimidamides is achieved directly from sulfenamides, themselves readily formed in one step from amines and disulfides. A highly chemoselective and one-pot NH and…
  • Optical Nanosensing of Lipid Accumulation due to Enzyme Inhibition in Live Cells. [Journal Article]
    ACS Nano 2019; 13(8):9363-9375Živanović V, Seifert S, … Kneipp J
  • Drugs that influence enzymes of lipid metabolism can cause pathological accumulation of lipids in animal cells. Here, gold nanoparticles, acting as nanosensors that deliver surface-enhanced Raman scattering (SERS) spectra from living cells provide molecular evidence of lipid accumulation in lysosomes after treatment of cultured cells with the three tricyclic antidepressants (TCA) desipramine, ami…
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