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167 results
  • Signaling by hydrogen sulfide and cyanide through post-translational modification. [Journal Article]
    J Exp Bot 2019; 70(16):4251-4265Gotor C, García I, … Romero LC
  • Two cysteine metabolism-related molecules, hydrogen sulfide and hydrogen cyanide, which are considered toxic, have now been considered as signaling molecules. Hydrogen sulfide is produced in chloroplasts through the activity of sulfite reductase and in the cytosol and mitochondria by the action of sulfide-generating enzymes, and regulates/affects essential plant processes such as plant adaptation…
  • L-Cysteine production by metabolically engineered Corynebacterium glutamicum. [Journal Article]
    Appl Microbiol Biotechnol 2019; 103(6):2609-2619Kondoh M, Hirasawa T
  • L-Cysteine is a commercially important amino acid. Here, we report the construction of L-cysteine-producing Corynebacterium glutamicum using a metabolic engineering approach. L-Serine O-acetyltransferase (SAT), encoded by cysE gene, is a key enzyme of L-cysteine biosynthesis, because of its feedback inhibition by L-cysteine. Therefore, we introduced a mutation into the C. glutamicum cysE gene, wh…
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