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69,791 results
  • Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria. [Review]
    Trends Parasitol 2019Vandermosten L, Vanhorebeek I, … Van den Steen PE
  • During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked. GCs are decisive for systemic regulation of vital processes such as immune responses, vascular function, and metabolism, which are crucial in malaria. Here, we introduce GCs in general, followed by their versatile roles fo…
  • A Lipid Micellar System Loaded with Dexamethasone Palmitate Alleviates Rheumatoid Arthritis. [Journal Article]
    AAPS PharmSciTech 2019; 20(8):316Wang X, Feng Y, … Zhang Q
  • Glucocorticoids have been confirmed to be effective in the treatment of a variety of inflammatory diseases. However, their application encounters limitations in terms of tissue distribution and bioavailability in vivo. To address these key issues, we designed and developed a nanopreparation by using egg yolk lecithin/sodium glycocholate (EYL/SGC) and utilize such mixed micelles (MMs) to encapsula…
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