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7,193 results
  • Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. [Journal Article]
    Brain 2019; 142(7):1887-1893Fridman EA, Osborne JR, … Schiff ND
  • Dopaminergic stimulation has been proposed as a treatment strategy for post-traumatic brain injured patients in minimally conscious state based on a clinical trial using amantadine, a weak dopamine transporter blocker. However, a specific contribution of dopaminergic neuromodulation in minimally conscious state is undemonstrated. In a phase 0 clinical trial, we evaluated 13 normal volunteers and …
  • The impact of psychostimulants on sustained attention over a 24-h period. [Journal Article]
    Cognition 2019; 193:104015Whitehurst LN, Agosta S, … Mednick SC
  • The off-label use of psychostimulants is a growing trend in healthy adults with many turning to these medications to increase alertness, attentional focus, and to help them study. However, the empirical literature on the efficacy of these medications for cognitive enhancement is controversial and the longer-term impact of these drugs on health and cognitive processing has not been thoroughly exam…
  • Morning stimulant administration reduces sleep and overnight working memory improvement. [Journal Article]
    Behav Brain Res 2019; 370:111940Tselha T, Whitehurst LN, … Mednick SC
  • The goal of cognitive enhancement is to improve mental functions using interventions including cognitive training, brain stimulation and pharmacology. Indeed, psychostimulants, commonly used for cognitive enhancement purposes, while preventing sleep, have been shown to increase working memory (WM) and attention. Sleep, however, is also important for cognitive function; thus, understanding the int…
  • Drug Overdose Deaths Involving Cocaine and Psychostimulants with Abuse Potential - United States, 2003-2017. [Journal Article]
    MMWR Morb Mortal Wkly Rep 2019; 68(17):388-395Kariisa M, Scholl L, … Hoots B
  • In 2016, a total of 63,632 persons died from drug overdoses in the United States (1). Drug overdose deaths involving cocaine, psychostimulants with abuse potential (psychostimulants), or both substances combined increased 42.4% from 12,122 in 2015 to 17,258 in 2016.* Psychostimulants with abuse potential include drugs such as methamphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), dextroamphe…
  • Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. [Journal Article]
    Pediatr Emerg Care 2019Minhaj FS, Schult RF, … Nacca N
  • Amphetamine toxicity typically presents with hypertension and tachycardia. Conversely, clonidine acts as an agonist at central α2 and imidazoline receptors, which may cause brief initial hypertension followed by hypotension and bradycardia in overdose. We report a case of mixed ingestion resulting in posterior reversible encephalopathy syndrome (PRES) successfully treated with phentolamine.A 17-y…
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