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2,820 results
  • Cytochrome P450-Mediated Metabolic Characterization of a Mono-Carbonyl Curcumin Analog WZ35. [Journal Article]
    Pharmacology 2019; :1-11Wang G, Li Y, … Zhang X
  • WZ35 is a monocarbonyl analog of curcumin, which had been proved advantage over curcumin in chemical stability and antitumor activity. However, its pharmacokinetic profile has not been determined. In the present study, an ultraperformance liquid chromatography-tandem mass spectrometry assay was developed to detect concentration of WZ35 in rat plasma. Subsequently, pharmacokinetic study showed tha…
  • Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva Cocktail. [Journal Article]
    J Pers Med 2019; 9(4)Bosilkovska M, Magliocco G, … Daali Y
  • Drug metabolic enzymes and transporters are responsible for an important variability in drug disposition. The cocktail approach is a sound strategy for the simultaneous evaluation of several enzyme and transporter activities for a personalized dosage of medications. Recently, we have demonstrated the reliability of the Geneva cocktail, combining the use of dried blood spots (DBS) and reduced dose…
  • Catatonia in Down syndrome: systematic approach to diagnosis, treatment and outcome assessment based on a case series of seven patients. [Journal Article]
    Neuropsychiatr Dis Treat 2019; 15:2723-2741Miles JH, Takahashi N, … Ithman M
  • CONCLUSIONS: Seven young adults with DS were diagnosed with catatonia; all responded to Lorazepam and/or ECT therapy with good to very good results. Though ECT most dramatically returned patients to baseline, symptoms often returned requiring additional ECT. Dextromethorphan/quinidine, not used until mid-2017, appeared to reduce the reoccurrence of symptoms following ECT. Though all seven patients improved significantly, each continues to require some form of treatment to maintain a good level of functioning. Findings of a significant number of autoimmune disorders and laboratory markers of immune activation in this population may guide new diagnostic and treatment opportunities.
  • Medication Errors from Over-the-Counter Cough and Cold Medications in Children. [Journal Article]
    Acad Pediatr 2019Wang GS, Reynolds KM, … Dart RC
  • CONCLUSIONS: In this multi-year surveillance study, medication errors most commonly occurred in children <6 years old who received the wrong volume of a liquid product. Diphenhydramine and dextromethorphan dosing errors were the most common cause of medication errors resulting from CCM use. Continued standardization of measuring devices, concentrations, and units of measure along with consumer education are needed to further decrease medication errors from CCMs.
  • A 2018 Approach to Combating Methotrexate Toxicity Folic Acid and Beyond. [Journal Article]
    Bull Hosp Jt Dis (2013) 2018; 76(3):151-155Labadie JG, Hashim R, … Jain M
  • Methotrexate (MTX) is the cornerstone to management across a variety of rheumatic diseases. Effective use and adherence to MTX treatment is dependent on toxicity prevention and management. The major deterrents to patient tolerability and adherence can include GI upset, hepatic transaminase elevation, stomatitis, hair loss, and CNS toxicity. Many rheumatologists are familiar with employing supplem…
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