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10,764 results
  • Glycosylation as an Important Regulator of Antibody Function. [Journal Article]
    Klin Onkol 2019; 32(Supplementum 3):46-55Uhrík L, Hernychová L, Vojtěšek B
  • The glycosylation of constant regions of antibodies significantly affects their interaction capabilities with immune cells. It is a modification that, in addition to the bio-logical activity of antibodies, has an impact on their conformation, stability, solubility, secretion, pharmaco-kinetics, and immunogenicity. The location of glycosylations on the molecule is essential for the proper function…
  • Impact of Physiological Signals Acquisition in the Emotional Support Provided in Learning Scenarios. [Journal Article]
    Sensors (Basel) 2019; 19(20)Uria-Rivas R, Rodriguez-Sanchez MC, … Boticario JG
  • Physiological sensors can be used to detect changes in the emotional state of users with affective computing. This has lately been applied in the educational domain, aimed to better support learners during the learning process. For this purpose, we have developed the AICARP (Ambient Intelligence Context-aware Affective Recommender Platform) infrastructure, which detects changes in the emotional s…
  • Isoantibodies, prevalence and risk factors in two hospitals in Mexico [Journal Article]
    Rev Med Inst Mex Seguro Soc 2019; 57(2):88-96González-Zenteno SG, Vargas-Ruiz ÁG
  • CONCLUSIONS: Erythrocyte alloimmunization in the population studied corresponded to a low prevalence. The main antibodies found were against Rh, Kell and Diego system antigens, with a different distribution than published in other international series. No previous report was found about the finding on group O as a protective factor for isoimmunization.
  • Data-Independent Acquisition for Yeast Glycoproteomics. [Journal Article]
    Methods Mol Biol 2019; 2049:191-202Zacchi LF, Schulz BL
  • Glycosylation is a complex posttranslational modification that is critical for regulating the functions of diverse proteins. Analysis of protein glycosylation is made challenging by the high degree of heterogeneity in both glycan occupancy and structure. Here, we describe methods for data-independent acquisition (SWATH) mass spectrometry analysis of structure and occupancy of N-glycans from yeast…
  • Nanoaperture fabrication via colloidal lithography for single molecule fluorescence analysis. [Journal Article]
    PLoS One 2019; 14(10):e0222964Jamiolkowski RM, Chen KY, … Goldman YE
  • In single molecule fluorescence studies, background emission from labeled substrates often restricts their concentrations to non-physiological nanomolar values. One approach to address this challenge is the use of zero-mode waveguides (ZMWs), nanoscale holes in a thin metal film that physically and optically confine the observation volume allowing much higher concentrations of fluorescent substra…
  • Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0. [Journal Article]
    J Proteome Res 2019Deutsch EW, Lane L, … Omenn GS
  • The Human Proteome Organization's (HUPO) Human Proteome Project (HPP) developed Mass Spectrometry (MS) Data Interpretation Guidelines that have been applied since 2016. These guidelines have helped ensure that the emerging draft of the complete human proteome is highly accurate and with low numbers of false-positive protein identifications. Here, we describe an update to these guidelines based on…
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