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687,087 results
  • Anti-diabetic compounds from the seeds of Psoralea corylifolia. [Journal Article]
    Fitoterapia 2019; :104373Zhu G, Luo Y, … Zhu M
  • A new aurone named (2Z)-2-[(4'-hydroxyphenyl) methylene]-6-hydroxy-7-prenyl-3(2H)-benzofurane (1), two new flavonoids named (2S)-7-methoxy-6-(2-hydroxy-3-methylbut-3-en-1-yl)-2-(4-hydroxyphenyl)chroman-4-one (2), (2S)-4'-hydroxyl-7-hydroxymethylene-6-(2″,3″-epoxy-3″-methylbutyl)flavanone (3), and a new coumestan named bavacoumestan E (4), together with eleven known compounds (5-15), were isolated…
  • Micro(RNA) management and mismanagement of the islet. [Review]
    J Mol Biol 2019Eliasson L, Regazzi R
  • Pancreatic β-cells located within the islets of Langerhans play a central role in metabolic control. The main function of these cells is to produce and secrete insulin in response to a rise in circulating levels of glucose and other nutrients. The release of insufficient insulin to cover the organism needs results in chronic hyperglycemia and diabetes development. β-cells insure a highly speciali…
  • Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes. [Review]
    J Mol Biol 2019Lytrivi M, Anne-Laure C, … Cnop M
  • The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may cause synergistic glucolipotoxicity. Lipo- and glucolipotoxicity have been studied for over 25 years. Here, we review the current evidence supporting the role of pancreatic β-cell lipo- and glucolipotoxicity in type 2 …
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