- Pre-Exposure Prophylaxis for the Prevention of HIV Infection: A Systematic Review for the U.S. Preventive Services Task Force [BOOK]
- BOOKAgency for Healthcare Research and Quality (US): Rockville (MD)
- CONCLUSIONS: In adults at increased risk of HIV infection, oral PrEP with tenofovir or tenofovir disoproxil fumarate plus emtricitabine is associated with decreased risk of HIV infection compared with placebo or no PrEP, although effectiveness decreases with inadequate adherence. PrEP is associated with increased risk of renal and gastrointestinal adverse events. Evidence on the accuracy of instruments for identifying persons at high risk of HIV infection is limited, with further validation needed.
- Three-dimensional digital reconstruction of renal model to guide preoperative planning of robot-assisted partial nephrectomy. [Journal Article]
- IJInt J Urol 2019 Jun 24
- Inflammatory Periimplant Diseases and the Periodontal Connection Question. [Journal Article]
- EJEur J Dent 2019; 13(1):119-123
- Implant therapy has become a widespread reality in modern dentistry. Nevertheless, dental implants can fail due to different causes, among which inflammatory peri-implant diseases (IPDs) are a major …
Implant therapy has become a widespread reality in modern dentistry. Nevertheless, dental implants can fail due to different causes, among which inflammatory peri-implant diseases (IPDs) are a major challenge, with prevalences that are much higher than previously believed.Specific searches were undertaken for each question raised between October and November 2017, in the PubMed website database (US National Library of Medicine, National Institutes of Health; Bethesda, Maryland, United States). Only articles written in English and published from 2007 onward were considered initially. The following keywords were used in the searches "periimplantitis (PI)," "periimplant mucositis (PM)," "dental implant failure," "periimplant microbiota," "periodontal microbiota," "implant failure" (no temporal limit), and "foreign body reaction" (no temporal limit). The selection process resulted in the selection of 239 articles that were analyzed in detail in elaborating this review. The reference list was limited to the 47 most relevant articles due to editorial limits of this Journal.Intrinsic differences between natural teeth and dental implants are able to give rise to inflammatory diseases that share only minor and scarcely relevant characters, and would consequently deserve different and specifically designed instruments and strategies, for both diagnosis and therapy.
- Primary hypophysitis: Experience of a Single Tertiary Center. [Journal Article]
- ECExp Clin Endocrinol Diabetes 2019 Jun 24
- CONCLUSIONS: Correctly diagnosing PH and giving appropriate treatment is challenging. It is unclear whether active treatment with steroids improves clinical outcomes. The serious adverse effects of steroids are also taken into account. Observation, surgery and/or radiotherapy can be appropriate treatment modalities for selected patients.
- Sleep in Parkinson's disease. [Review]
- NNeuropsychopharmacology 2019 Jun 24
- Sleep disturbances are common in Parkinson's disease and comprise the entire spectrum of sleep disorders. On the one hand regulation of sleep and wakefulness is affected in Parkinson's disease, leadi…
Sleep disturbances are common in Parkinson's disease and comprise the entire spectrum of sleep disorders. On the one hand regulation of sleep and wakefulness is affected in Parkinson's disease, leading to the development of disorders, such as insomnia and daytime sleepiness. While on the other hand control of motor activity during sleep is impaired, with subsequent manifestation of parasomnias (mainly REM sleep behavior disorders, but also, albeit more rarely, sleepwalking, and overlap parasomnia). Restless legs syndrome has been reported to be frequent in patients with Parkinson's disease, although there is no consensus on whether it is more frequent in Parkinson's disease than in the general population. The same is true for sleep-related breathing disorders. Regarding the diagnosis of sleep disorders in patients with Parkinson's disease, one of the main challenges is correctly identifying excessive daytime sleepiness as there are many potential confounding factors, for example it is necessary to distinguish sleep-related breathing disorders from medication effects, and to distinguish restless legs syndrome from the concomitant presence of potential mimics specific to Parkinson's disease, such as akathisia, nocturnal leg cramps, nocturnal hypokinesia, early morning dystonia, etc. The correct diagnosis of REM sleep behavior disorder is also not always easy, and video-polysomnography should be performed in order to exclude mimic-like movements at the end of sleep apneas or violent periodic leg movements of sleep. These aspects and specific considerations about diagnosis and treatment of sleep disorders in patients with Parkinson's disease will be reviewed.
- Chitosan Oligosaccharide Exerts Anti-Allergic Effect against Shrimp Tropomyosin-Induced Food Allergy by Affecting Th1 and Th2 Cytokines. [Journal Article]
- IAInt Arch Allergy Immunol 2019 Jun 24; :1-7
- CONCLUSIONS: COS showed anti-allergy properties by regulating the levels of Th1 and Th2 cytokines.
- "Weekend Effect" on 30-Day Readmissions among Stroke Survivors: An Analysis of the National Readmission Database. [Journal Article]
- CDCerebrovasc Dis Extra 2019 Jun 24; 9(2):66-71
- CONCLUSIONS: We found no association between weekend admission and 30-day readmissions, providing indirect evidence of homogeneity in the quality of care delivered during week day and weekend admissions.
- Determinants of Well-Being and Their Implications for Health Care. [Journal Article]
- ANAnn Nutr Metab 2019; 74 Suppl 2:8-14
- The paper explains how subjective well-being can be measured, how the resulting data are being used to document human progress and how health care can be changed to take advantage of what has been le…
The paper explains how subjective well-being can be measured, how the resulting data are being used to document human progress and how health care can be changed to take advantage of what has been learned. The evaluations that people make of their own lives document, and permit the explanation of, life satisfaction levels that differ greatly among countries and communities. Research seeking to explain these happiness differences, and their related differences in mortality and morbidity, exposes the importance of the social context. There is an opportunity and need to change health care from the diagnosis and treatment of illness to the fostering of wellness. The importance of the social context in the successful design and delivery of health and happiness is so great as to support a prescription to turn the "I" into "we," thereby turning illness into wellness by making the production and maintenance of health and happiness a much more collaborative activity, even in the presence of the increasing complexity of medical science.
- Announcement: The International System for Reporting Serous Fluid Cytopathology. [Editorial]
- ACActa Cytol 2019 Jun 24; :1-3
- Serous fluids are a common but important specimen type in a cytopathology laboratory. There is as yet no agreed standardized terminology to allow uniformity in reporting on these specimens. Given tha…
Serous fluids are a common but important specimen type in a cytopathology laboratory. There is as yet no agreed standardized terminology to allow uniformity in reporting on these specimens. Given that serous fluids are a rich source of cytopathological as well as molecular information on a range of benign and often advanced malignant conditions, a unified approach to handling and reporting these specimens covering the pre-analytical, analytical and postanalytical stages seems timely. Representatives of the international cytology community have come together once again to develop an algorithmic diagnostic and management approach to the reporting of these samples.
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- Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease. [Journal Article]
- CMCardiorenal Med 2019 Jun 24; :1-10
- CONCLUSIONS: Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain.