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114,208 results
  • Trial of Apremilast for Oral Ulcers in Behçet's Syndrome. [Journal Article]
    N Engl J Med 2019; 381(20):1918-1928Hatemi G, Mahr A, … Yazici Y
  • CONCLUSIONS: In patients with oral ulcers associated with Behçet's syndrome, apremilast resulted in a greater reduction in the number of oral ulcers than placebo but was associated with adverse events, including diarrhea, nausea, and headache. (Funded by Celgene; number, NCT02307513.).
  • Probiotics in hospitalized adult patients: a systematic review of economic evaluations. [Review]
    Can J Anaesth 2019Lau VI, Rochwerg B, … Cook DJ
  • CONCLUSIONS: Probiotics may be an economically attractive intervention for preventing ventilator-associated pneumonia, Clostridioides difficile-associated diarrhea, and antibiotic-associated diarrhea in hospitalized adult patients. Nevertheless, certainty about their cost-effectiveness evidence is very low. Future RCTs examining probiotics should incorporate cost data to inform bedside practice, clinical guidelines, and healthcare policy.
  • Drug-Induced Small Bowel Injury: a Challenging and Often Forgotten Clinical Condition. [Review]
    Curr Gastroenterol Rep 2019; 21(11):55Scarpignato C, Bjarnason I
  • Most drugs are given by the oral route. Oral intake allows direct contact between the drug and the entire GI tract mucosa, exposing it to potential topical damage until absorption. Medication-induced GI symptoms and lesions are therefore commonly encountered in clinical practice. This review will examine the most common drugs or classes of drugs affecting small bowel function and/or structure.
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