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589 results
  • A microRNA-Messenger RNA Regulatory Network and Its Prognostic Value in Cervical Cancer. [Journal Article]
    DNA Cell Biol. 2020 May 22 [Online ahead of print]Liu J, Yang J, … Cheng W
  • Cervical cancer (CC) is the fourth commonest cancer in women worldwide. Increasing evidence proves that microRNA (miRNA)-messenger RNA (mRNA) network is involved in CC. In this study, miRNA and mRNA expression profiles were downloaded from The Cancer Genome Atlas (TCGA) database. Differently expressed miRNAs (DE-miRNAs) and mRNAs (DE-mRNAs) were obtained by "Empirical Analysis of Digital Gene Exp…
  • A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms. [Journal Article]
    FEBS Open Bio. 2020 May 19 [Online ahead of print]Hillen LM, Geybels MS, … Winnepenninckx V
  • Spitzoid neoplasms are a challenging group of cutaneous melanocytic proliferations. They are characterized by epithelioid and/ or spindle-shaped melanocytes and classified as benign Spitz nevi (SN), atypical Spitz tumors (AST) or malignant Spitz tumors (MST). The intermediate AST category represents a diagnostically challenging group since on purely histopathological grounds, their benign or mali…
  • Culturomics-based genomics sheds light on the ecology of the new haloarchaeal genus Halosegnis. [Journal Article]
    Environ Microbiol. 2020 May 14 [Online ahead of print]Durán-Viseras A, Andrei AŞ, … Ventosa A
  • The development of culture-independent techniques has revolutioned our understanding of microbial ecology, especially through the illustration of the vast gap between the environmentally abundant microbial diversity and that accessible through cultivation. However, culture-based approaches are not only crucial for understanding the evolutionary, metabolic and ecological milieu of microbial divers…
  • Type I interferon in children with viral or bacterial infections. [Journal Article]
    Clin Chem. 2020 May 02 [Online ahead of print]Trouillet-Assant S, Viel S, … Antoine study group
  • CONCLUSIONS: IFN-α is increased in blood of febrile infants with viral infections. The discriminative performance of IFN-α femtomolar concentrations as well as blood transcriptional signatures could show a diagnostic benefit and potentially limit antibiotic overuse.
  • Tower of Belém (Lisbon)-Status Quo 3D Documentation and Material Origin Determination. [Journal Article]
    Sensors (Basel). 2020 Apr 21; 20(8)Redweik P, de Sanjosé Blasco JJ, … Martínez Corrales LF
  • The Tower of Belém, an early 16th century defense tower located at the mouth of the Tagus river, is the iconic symbol of Lisbon. It belongs to the Belém complex, classified since 1983 as a World Heritage Site by the UNESCO, and it is the second most visited monument in Portugal. On November 1st, 1755, there was a heavy earthquake in Lisbon followed by a tsunami, causing between 60,000 and 100,000…
  • Self validating Mueller matrix Micro-Mesoscope (SAMMM) for the characterization of biological media. [Journal Article]
    Opt Lett. 2020 Apr 15; 45(8):2168-2171.Saytashev I, Saha S, … Ramella-Roman JC
  • Reflectance Mueller matrix (MM) polarimetry is being used to characterize biological media in multiple clinical applications. The origin of the reflectance polarimetric data is often unclear due to the impact of multiple scattering and tissue heterogeneity. We have developed a new, to the best of our knowledge, multimodal imaging technique combining MM reflectance, MM digital confocal imaging, an…
  • Computational design of anti-CRISPR proteins with improved inhibition potency. [Journal Article]
    Nat Chem Biol. 2020 Apr 13 [Online ahead of print]Mathony J, Harteveld Z, … Niopek D
  • Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhibitor, to improve its efficacy on different targets. We first show that inserting exogenous protein domains into a selected AcrIIC1 surface site drama…
  • 280-km experimental demonstration of a quantum digital signature with one decoy state. [Journal Article]
    Opt Lett. 2020 Apr 01; 45(7):1711-1714.Ding HJ, Chen JJ, … Wang Q
  • A quantum digital signature (QDS) guarantees the unforgeability, nonrepudiation, and transferability of signature messages with information-theoretic security, and hence has attracted much attention recently. However, most previous implementations of QDS showed relatively low signature rates and/or short transmission distance. In this Letter, we report a proof-of-principle phase-encoding QDS demo…
  • Biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer. [Journal Article]
    Chin Clin Oncol. 2020 Mar 13 [Online ahead of print]Iwamoto T, Kajiwara Y, … Iha S
  • The improvement of tumor biomarkers prepared for clinical use is a long process. A good biomarker should predict not only prognosis but also the response to therapies. In this review, we describe the biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer, considering different breast cancer subtypes. In hormone receptor (HR)-positive/human epidermal growth factor 2 (HER2)-negative brea…
  • Efficient NTRU Lattice-Based Certificateless Signature Scheme for Medical Cyber-Physical Systems. [Journal Article]
    J Med Syst. 2020 Mar 18; 44(5):92.Xu Z, He D, … Li L
  • An electronic health (e-health) system, such as a medical cyber-physical system, offers a number of benefits (e.g. inform medical diagnosis). There are, however, a number of considerations in the implementation of the medical cyber-physical system, such as the integrity of medical / healthcare data (e.g. manipulated data can result in misdiagnosis). A number of digital signature schemes have been…
  • Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma. [Journal Article]
    Front Oncol. 2020; 10:183.Tao C, Huang K, … Zhu X
  • CONCLUSIONS: EMT-related induction factors, transcriptional regulators and signaling pathways genes are important players in the malignant progression of glioma and may help in decision making regarding the choice of prognosis assessment and provide us clues to understand EMT epigenetic modification in glioma.
  • Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices. [Journal Article]
    Digit Biomark. 2019 Sep-Dec; 3(3):103-115.Gordon MF, Grachev ID, … Hayden MR
  • Previous studies have demonstrated the feasibility and promise of wearable sensors as objective measures of motor impairment in Parkinson disease and essential tremor. However, there are few published studies that have examined such an application in Huntington disease (HD). This report provides an evaluation of the potential to objectively quantify chorea in HD patients using wearable sensor dat…
  • Tertiary lymphoid structures improve immunotherapy and survival in melanoma. [Journal Article]
    Nature. 2020 01; 577(7791):561-565.Cabrita R, Lauss M, … Jönsson G
  • Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T …
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