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2,886 results
  • [Cancer cell-specific functional relation between Na+,K+-ATPase and volume-regulated anion channel]. [Journal Article]
    Nihon Yakurigaku Zasshi 2019; 154(3):103-107Fujii T, Shimizu T, … Sakai H
  • Digitoxin and digoxin are plant-derived cardiac glycosides. They are Na+,K+-ATPase (sodium pump) inhibitors, and have been used clinically for treatment and prevention of heart failure and various tachycardia. On the other hand, some epidemiological studies showed that digoxin users have a lower cancer risk compared to the non-users, and that cancer patients who had been treated with digoxin face…
  • [Simultaneous LC-MS/MS Determination of 18 Plant Toxins in Beverages]. [Journal Article]
    Shokuhin Eiseigaku Zasshi 2019; 60(4):108-112Oishi A, Nagatomi Y, Suzuki K
  • Assuming the intentional adulteration of beverages with plant toxins, an LC-MS/MS method for the simultaneous determination of 18 plant toxins (lycorine, galantamine, ricinine, scopolamine, gelsemine, atropine, colchicine, α-solanine, jervine, α-chaconine, veratramine, mesaconitine, digoxin, protoveratrine A, aconitine, hypaconitine, oleandrin, and digitoxin) was developed. As analytical samples,…
  • Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer. [Journal Article]
    Front Oncol 2019; 9:630Pollard BS, Suckow MA, … Pollard HB
  • Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor suppressor, but in advanced metastatic disease it switches to being a tumor promoter. TGFBR2 may play a critical role in this collaboration, as its expr…
  • Cardiac Glycosides in Human Physiology and Disease: Update for Entomologists. [Review]
    Insects 2019; 10(4)El-Mallakh RS, Brar KS, Yeruva RR
  • Cardiac glycosides, cardenolides and bufadienolides, are elaborated by several plant or animal species to prevent grazing or predation. Entomologists have characterized several insect species that have evolved the ability to sequester these glycosides in their tissues to reduce their palatability and, thus, reduce predation. Cardiac glycosides are known to interact with the sodium- and potassium-…
  • Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives. [Journal Article]
    Eur J Med Chem 2019; 167:546-561Boff L, Munkert J, … Oliveira Simões CM
  • In recent years, new therapeutic possibilities were proposed for cardiac glycosides traditionally used to treat heart diseases, such as anticancer and antiviral activities. In this sense, this work aimed to synthesize the readily accessible 3β-azido-3-deoxydigitoxigenin (5) from digitoxigenin (1). Two new series of compounds were obtained from derivative (5): (i) O-glycosyl trizols through click …
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