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(diphenhydrAMINE)
6,147 results
  • Highly conserved intracellular H208 residue influences agonist selectivity in bitter taste receptor T2R14. [Journal Article]
    Biochim Biophys Acta Biomembr 2019; 1861(12):183057Shaik FA, Jaggupilli A, Chelikani P
  • Bitter taste receptors (T2Rs) are a specialized class of cell membrane receptors of the G protein-coupled receptor family and perform a crucial role in chemosensation. The 25 T2Rs in humans are activated by structurally diverse ligands of plant, animal and microbial origin. The mechanisms of activation of these receptors are poorly understood. Therefore, identification of structural determinants …
  • Differential long-term regulation of TAS2R14 by structurally distinct agonists. [Journal Article]
    FASEB J 2019; :fj201802627RRWoo JA, Castaño M, … Liggett SB
  • Bitter taste receptor-14 (TAS2R14) is a GPCR also expressed on human airway smooth muscle cells, which signals to intracellular [Ca2+], resulting in relaxation of the airway, and is a novel target for bronchodilators. Here, we examine long-term, agonist-promoted down-regulation of TAS2R14 expression because tachyphylaxis would be an undesirable therapeutic characteristic. Five TAS2R structurally …
  • Suspected anaphylactic shock associated with administration of tranexamic acid in a dog. [Journal Article]
    J Vet Med Sci 2019Choi JY, Kim JH, Han HJ
  • A 10-year-old male castrated Maltese was referred with clinical signs of hematuria, stranguria, and pollakiuria. The dog was diagnosed with sterile hemorrhagic cystitis with urethroliths and cystoliths. To remove the uroliths, the dog underwent retrograde urohydropropulsion followed by a cystotomy. The following day, persistent bleeding in the urinary bladder was identified with large hematoma, h…
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