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Unbound Medicine.
(disaccharidase)
4,806 results
  • [Pharmacological and clinical feature of rebamipide: new therapeutic targets]. [Journal Article]
    Ter Arkh. 2020 Apr 27; 92(2):104-111.Zvyaglova MY, Knyazev OV, Parfenov AI
  • Rebamipide is a cytoprotector developed in Japan where it has been successfully used for the treatment of stomach diseases for 30 years. Initially discovered effects of the drug included the induction of prostaglandins and the elimination of free oxygen radicals. Recent studies discovered new therapeutic targets of the drug, its new forms that made possible using rebamipid for the treatment of su…
  • Stool Reducing Sugars and Stool pH Are Poor Screening Tests for Intestinal Disaccharidase Deficiencies in Children. [Journal Article]
    J Appl Lab Med. 2020 Mar 01; 5(2):257-262.Erickson JA, Case K, … Johnson LM
  • CONCLUSIONS: The screening tests, stool reducing sugars and stool pH, had low sensitivity compared with results of measured tissue disaccharidase activity in pediatric patients. Infants had the highest percentage of abnormal results for all three tests, but the screening tests still performed poorly in that age group. This study suggests that stool reducing sugars and stool pH should not be used as screening tests for carbohydrate malabsorption due to disaccharidase deficiencies in pediatric patients.
  • Hypomorphic SI genetic variants are associated with childhood chronic loose stools. [Journal Article]
    PLoS One. 2020; 15(5):e0231891.Chumpitazi BP, Lewis J, … Di Lorenzo C
  • CONCLUSIONS: Non-Hispanic white children with chronic idiopathic loose stools have a higher prevalence of CSID-associated hypomorphic SI variants than the general population. The GI symptom burden was greater among the study subjects with a hypomorphic SI variant than those without hypomorphic SI variants.
  • Effects of Bidens gardneri Baker leaves aqueous extract in glucose homeostasis of rats. [Journal Article]
    Biomed Pharmacother. 2020 Jul; 127:110185.Félix JM, Bertoncello LA, … Trichez VDK
  • Bidens gardneri Baker, popularly known as "picão-vermelho", has been used, traditionally, as a medicinal plant for the treatment of Diabetes mellitus. This study aimed to evaluate antidiabetic effect of leaves from B. gardneri aqueous extract (BGAE). We also evaluated in vitro anti-glycation potential. Chemical composition was analyzed based on a colorimetrics and HPLC methods. The oral glucose t…
  • Prevalence of Disaccharidase Deficiency in Adults With Unexplained Gastrointestinal Symptoms. [Journal Article]
    J Neurogastroenterol Motil. 2020 May 07 [Online ahead of print]Viswanathan L, Rao SSC, … Jimenez E
  • CONCLUSIONS: Isolated disaccharidase deficiency occurs in adults, usually lactase and rarely maltase. Pandisaccharidase deficiency is rare. Baseline symptoms or its severity did not predict enzyme deficiency. LBT has good specificity and diagnostic agreement with lactase assay and may be more cost-effective. In adults with refractory gastrointestinal symptoms, disaccharidase testing detects enzyme deficiency in approximately one-half of patients and can aid diagnosis and management.
  • [Screening and bioinformatic analysis of trehalase in Thelazia callipaeda]. [Journal Article]
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Feb 18; 32(1):60-68.Zheng MH, Ye CL, … Xu DL
  • CONCLUSIONS: A trehalase gene is successfully identified in T. callipaeda genome and its coding protein receives a bioinformatics analysis, which provides insights into the research on the biological functions of the protein and the screening of vaccine candidates for thelaziasis callipaeda.
  • Routine disaccharidase testing: are we there yet? [Journal Article]
    Curr Opin Gastroenterol. 2020 Mar; 36(2):101-109.Opekun AR, Chumpitazi BP, … Nichols BL
  • CONCLUSIONS: The rationale for disaccharidase activity testing relates to a need to fully assess unexplained recurrent abdominal discomfort and associated symptoms. All disaccharidases share the same basic mechanism of mucosal expression and deficiency has far reaching consequences. Testing for disaccharidase expression appears to have an important role in symptom evaluation, but there are accuracy and logistical issues that should be considered. It is likely that specific recommendations for patient management, dietary modification, and enzyme supplementation would come from better testing methods.
  • Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review. [Review]
    Clin Biochem Rev. 2019 Nov; 40(4):167-174.Burke M
  • Carbohydrate intolerance is one of several syndromes and diseases which together are known as malabsorption syndromes. These include small intestinal bacterial overgrowth (SIBO), coeliac disease, intestinal lymphangiectasia, short bowel syndrome, tropical sprue and some inherited metabolic disorders such as galactosaemia and pyruvate kinase deficiency. Specifically, the malabsorption of sugars af…
  • Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats. [Journal Article]
    J Therm Biol. 2019 Oct; 85:102415.Cheng K, Song Z, … Wang T
  • Heat stress, experienced by humans and animals under high ambient temperatures, is known to induce oxidative stress and inflammation, which endangers human health as well as animal welfare and production. The gastrointestinal tract is predominantly responsive to heat stress and compromised intestinal functions can contribute to multi-organ injury under heat environment. Resveratrol (RSV) has sign…
  • Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome. [Journal Article]
    Dig Dis Sci. 2020 Feb; 65(2):534-540.Kim SB, Calmet FH, … Moshiree B
  • CONCLUSIONS: SID was found in 35% of patients with presumed IBS-D/M and should be considered in the differential diagnosis of patients presenting with abdominal pain, diarrhea, or bloating. Further studies should better characterize the clinical features of SID and investigate the effects of dietary modification in this group of patients.
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