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193 results
  • Membrane Rearrangements in the Maturation of Circulating Human Reticulocytes. [Journal Article]
    Front Physiol. 2020; 11:215.Minetti G, Bernecker C, … Ciana A
  • Red blood cells (RBCs) begin their circulatory life as reticulocytes (Retics) after their egress from the bone marrow where, as R1 Retics, they undergo significant rearrangements in their membrane and intracellular components, via autophagic, proteolytic, and vesicle-based mechanisms. Circulating, R2 Retics must complete this maturational process, which involves additional loss of significant amo…
  • Normal red blood cells' shape stabilized by membrane's in-plane ordering. [Journal Article]
    Sci Rep. 2019 Dec 24; 9(1):19742.Mesarec L, Góźdź W, … Kralj S
  • Red blood cells (RBCs) are present in almost all vertebrates and their main function is to transport oxygen to the body tissues. RBCs' shape plays a significant role in their functionality. In almost all mammals in normal conditions, RBCs adopt a disk-like (discocyte) shape, which optimizes their flow properties in vessels and capillaries. Experimentally measured values of the reduced volume (v) …
  • Characteristics of phospholipid vesicles enhanced by adhesion on an annular region. [Journal Article]
    Phys Rev E. 2019 May; 99(5-1):052416.Majhenc J, Božič B
  • Phospholipid vesicle membranes are simple models used to study the mechanical properties of cell membranes. The shapes of flaccid vesicles can exhibit very diverse forms. When researching very flaccid vesicles, axisymmetrical vesicles with the membranes adhered to an annular region can also be observed. A phase diagram of such shapes was studied for different values of the vesicle parameters, i.e…
  • A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies. [Journal Article]
    PLoS One. 2019; 14(4):e0215447.Geekiyanage NM, Balanant MA, … Gu Y
  • An improved red blood cell (RBC) membrane model is developed based on the bilayer coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte-echinocyte (SDE) transformation of a RBC. The coarse-grained (CG)-RBC membrane model is proposed to predict the minimum energy configuration of the RBC from the competition between lipid-bilayer bending resistance and cytoskele…
  • Image-Based Flow Cytometry and Angle-Resolved Light Scattering to Define the Sickling Process. [Journal Article]
    Cytometry A. 2019 May; 95(5):488-498.Goktas P, Sukharevsky IO, … Altintas A
  • Red blood cells (RBCs) from sickle cell patients exposed to a low oxygen tension reveal highly heterogeneous cell morphologies due to the polymerization of sickle hemoglobin (HbS). We show that angle-resolved light scattering approach with the use of image-based flow cytometry provides reliable quantitative data to define the change in morphology of large populations of RBCs from sickle cell pati…
  • Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging. [Journal Article]
    Biomed Opt Express. 2018 Oct 01; 9(10):4714-4729.Jaferzadeh K, Moon I, … Marquet P
  • We propose methods to quantitatively calculate the fluctuation rate of red blood cells with nanometric axial and millisecond temporal sensitivity at the single-cell level by using time-lapse holographic cell imaging. For this quantitative analysis, cell membrane fluctuations (CMFs) were measured for RBCs stored at different storage times. Measurements were taken over the whole membrane for both t…
  • Morphology of depletant-induced erythrocyte aggregates. [Journal Article]
    Soft Matter. 2018 Oct 17; 14(40):8160-8171.Nehring A, Shendruk TN, de Haan HW
  • Red blood cells suspended in quiescent plasma tend to aggregate into multicellular assemblages, including linearly stacked columnar rouleaux, which can reversibly form more complex clusters or branching networks. While these aggregates play an essential role in establishing hemorheological and pathological properties, the biophysics behind their self-assembly into dynamic mesoscopic structures re…
  • Erythrocyte Membrane Failure by Electromechanical Stress. [Journal Article]
    Appl Sci (Basel). 2018; 8(2)Du E, Qiang Y, Liu J
  • We envision that electrodeformation of biological cells through dielectrophoresis as a new technique to elucidate the mechanistic details underlying membrane failure by electrical and mechanical stresses. Here we demonstrate the full control of cellular uniaxial deformation and tensile recovery in biological cells via amplitude-modified electric field at radio frequency by an interdigitated elect…
  • Monitoring dynamic spiculation in red blood cells with scanning ion conductance microscopy. [Journal Article]
    Analyst. 2018 Feb 26; 143(5):1087-1093.Zhu C, Shi W, … Baker LA
  • Phospholipids are critical structural components of the membrane of human erythrocytes and their asymmetric transbilayer distribution is essential for normal cell functions. Phospholipid asymmetry is maintained by transporters that shuttle phospholipids between the inner leaflet and the outer leaflet of the membrane bilayer. When an exogenous, short acyl chain, phosphatidylcholine (PC) or phospha…
  • Changes in hemoglobin-oxygen affinity with shape variations of red blood cells. [Journal Article]
    J Biomed Opt. 2017 Oct; 22(10):1-9.Chowdhury A, Dasgupta R, Majumder SK
  • Shape variations of red blood cells (RBCs) are known to occur upon exposure to various drugs or under diseased conditions. The commonly observed discocytic RBCs can be transformed to echinocytic or stomatocytic shape under such conditions. Raman spectra of the three major shape variations, namely discocyte, echinocyte, and stomatocyte, of RBCs were studied while subjecting the cells to oxygenated…
  • Biolens behavior of RBCs under optically-induced mechanical stress. [Journal Article]
    Cytometry A. 2017 05; 91(5):527-533.Merola F, Barroso Á, … Denz C
  • In this work, the optical behavior of Red Blood Cells (RBCs) under an optically-induced mechanical stress was studied. Exploiting the new findings concerning the optical lens-like behavior of RBCs, the variations of the wavefront refracted by optically-deformed RBCs were further investigated. Experimental analysis have been performed through the combination of digital holography and numerical ana…
  • Investigation on dynamics of red blood cells through their behavior as biophotonic lenses. [Journal Article]
    J Biomed Opt. 2016 12 01; 21(12):121509.Memmolo P, Merola F, … Ferraro P
  • The possibility to adopt biological matter as photonic optical elements can open scenarios in biophotonics research. Recently, it has been demonstrated that a red blood cell (RBC) can be seen as an optofluidic microlens by showing its imaging capability as well as its focal tunability. Moreover, correlation between an RBC’s morphology and its behavior as a refractive optical element has been esta…
  • Cell morphology-based classification of red blood cells using holographic imaging informatics. [Journal Article]
    Biomed Opt Express. 2016 Jun 01; 7(6):2385-99.Yi F, Moon I, Javidi B
  • We present methods that automatically select a linear or nonlinear classifier for red blood cell (RBC) classification by analyzing the equality of the covariance matrices in Gabor-filtered holographic images. First, the phase images of the RBCs are numerically reconstructed from their holograms, which are recorded using off-axis digital holographic microscopy (DHM). Second, each RBC is segmented …
  • Shape transformations of toroidal vesicles. [Journal Article]
    Soft Matter. 2015 Jan 07; 11(1):193-201.Noguchi H, Sakashita A, Imai M
  • Morphologies of genus-1 and 2 toroidal vesicles are studied numerically by dynamically triangulated membrane models and experimentally by confocal laser microscopy. Our simulation results reproduce shape transformations observed in our experiments well. At large reduced volumes of the genus-1 vesicles, obtained vesicle shapes agree with the previous theoretical prediction, in which axisymmetric s…
  • Optical assay of erythrocyte function in banked blood. [Journal Article]
    Sci Rep. 2014 Sep 05; 4:6211.Bhaduri B, Kandel M, … Popescu G
  • Stored red blood cells undergo numerous biochemical, structural, and functional changes, commonly referred to as storage lesion. How much these changes impede the ability of erythrocytes to perform their function and, as result, impact clinical outcomes in transfusion patients is unknown. In this study we investigate the effect of the storage on the erythrocyte membrane deformability and morpholo…
  • Interaction of injectable neurotropic drugs with the red cell membrane. [Journal Article]
    Toxicol In Vitro. 2014 Oct; 28(7):1274-9.Reinhart WH, Lubszky S, … Schulzki T
  • The normal red blood cell (RBC) shape is a biconcave discocyte. An intercalation of a drug in the outer half of the membrane lipid bilayer leads to echinocytosis, an intercalation in the inner half to stomatocytosis. We have used the shape transforming capacity of RBCs as a model to analyse the membrane interaction potential of various neurotropic drugs. Chlorpromazine, clomipramine, citalopram, …
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