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40,915 results
  • Adsorption of a Poorly Water-Soluble Drug onto Porous Calcium Silicate by the Sealed Heating Method. [Journal Article]
    Int J Pharm. 2020 Jul 11 [Online ahead of print]Kawano Y, Chen S, Hanawa T
  • To improve the bioavailability of orally-administered drug, solubilization of poorly water-soluble drug is important. The solubility of a drug in its amorphous form is known to be higher than in its crystalline form. In this study, we attempted to adsorb a sublimable drug onto porous calcium silicate (Florite®, FLR) or non-porous calcium silicate (NPCS) by the sealed heating (SH) method and evapo…
  • A study on polymorphic forms of rifampicin for inhaled high dose delivery in tuberculosis treatment. [Journal Article]
    Int J Pharm. 2020 Jul 11 [Online ahead of print]Khadka P, Hill PC, … Das SC
  • Rifampicin is a first-line, highly effective drug currently used orally as a part of a lengthy multi-drug regimen against tuberculosis (TB). Despite the potential of inhaled therapy as an effective approach for TB treatment, an inhalable formulation of rifampicin has not yet been developed for clinical use. In order to do so, it is necessary to evaluate its solid-state properties, which regulate …
  • Surface reactivity and dissolution properties of alumina-silica glasses and fibers. [Journal Article]
    ACS Appl Mater Interfaces. 2020 Jul 14 [Online ahead of print]Okhrimenko DV, Nielsen CF, … Stipp SLS
  • The ability of bulk glass and fibers to react in aqueous solution, with organic polymers and coupling agents, depends on the surface charge, reactivity and adsorption properties of the glass surface, i.e. the character and density of surface -OH groups, whereas glass and fiber chemical stability and biosolubility depend on the resistance to dissolution. If glass dissolution products are accumulat…
  • Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach. [Journal Article]
    Pharmaceutics. 2020 Jul 09; 12(7)Buol X, Robeyns K, … Leyssens T
  • In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initi…
  • Self-coagulating polyelectrolyte complexes for target-tunable adsorption and separation of metal ions. [Journal Article]
    J Hazard Mater. 2020 Jun 30; 401:123352.Bediako JK, Choi JW, … Yun YS
  • Metal-containing wastes in aquatic environments lead to public health hazards and valuable resource lose. Metal-bearing wastewater must be treated to remove heavy metals or recover precious metals. To achieve these, target-tunable adsorbents that bind cationic and anionic metal species were developed through facile polyelectrolyte complexation using polyethylenimine (PEI) and polyacrylic acid (PA…
  • Dissolution kinetics of biogenic silica and the recalculated silicon balance of the East China Sea. [Journal Article]
    Sci Total Environ. 2020 Jun 26; 743:140552.Wu B, Liu S
  • We conducted field observations in the East China Sea (ECS) in 2010 and 2011 to determine the content and dissolution dynamics of bSiO2 in sediments of the ECS. The influencing factors on bSiO2 dissolution were investigated, and the regional silicon budget was recalculated. The sediment bSiO2 content in the ECS varied from 143 to 583 μmol g-1. The burial flux of bSiO2 ranged from 0.11 to 19 mol m…
  • A novel cascade strategy using a nanonized targeted prodrug for enhanced oral delivery efficiency. [Journal Article]
    Int J Pharm. 2020 Jul 10 [Online ahead of print]Guo M, Yu S, … He Z
  • It is a great challenge to improve the oral bioavailability for BCS class IV drugs because they have low solubility and poor permeability. However, nanonization and intestinal transporter-targeted prodrugs can increase the solubility and permeability, respectively. Hence, an "increased solubility and improved permeability" cascade strategy was proposed to enhance the dissolution rate and permeabi…
  • Customized Fast-Separable Microneedles Prepared with the Aid of 3D Printing for Nanoparticle Delivery. [Journal Article]
    Eur J Pharm Biopharm. 2020 Jul 10 [Online ahead of print]El-Sayed N, Vaut L, Schneider M
  • 3D printing of master molds for soft lithography-based fabrication of microneedles (MNs) is a cost effective, easy and fast method for producing MNs with variable designs. Deviating from the classical geometries of MNs, 'tanto blade'-inspired MNs showed effective skin penetration, acting as sharp structures with low insertion force of 10.6 N, which is sufficient for manual insertion. Additionally…
  • An on-Demand Dissoluble Diselenide-Containing Hydrogel. [Journal Article]
    Biomacromolecules. 2020 Jul 13 [Online ahead of print]Lu W, Xu X, … Pan X
  • On-demand dissolution of hydrogels is being increasingly studied for their potential use in burn wound dressing applications. Herein, a dynamic diselenide-containing hydrogel is developed through a very simple one-pot process starting from the selenol functionalization of a partially hydrolyzed poly(2-ethyl-2-oxazoline) with γ-butyroselenolactone. The hydrogel spontaneously crosslinks via an in-s…
  • Strontium Substitution of Gelatin Modified Calcium Hydrogen Phosphates as Porous Hard Tissue Substitutes. [Journal Article]
    J Biomed Mater Res A. 2020 Jul 12 [Online ahead of print]Kruppke B, Heinemann C, … Hanke T
  • Aiming at the generation of a high strontium-containing degradable bone substitute, the exchange of calcium with strontium in gelatin-modified brushite was investigated. The ion substitution showed two mineral groups, the high-calcium containing minerals with a maximum measured molar Ca/Sr ratio of 80%/20% (mass ratio 63%/37%) and the high-strontium containing ones with a maximum measured molar C…
  • Exploring potential coformers for oxyresveratrol using principal component analysis. [Journal Article]
    Int J Pharm. 2020 Jul 08 [Online ahead of print]Ouiyangkul P, Tantishaiyakul V, Hirun N
  • Oxyresveratrol (OXY) exhibits poor bioavailability due to its low solubility. Cocrystals are effective in improving solubility of OXY. In this study, principal component analysis (PCA) was employed for coformer selection using 5 variables (solubility parameter, logP, hydrogen bonding acceptor, hydrogen bonding donor and molecular volume). According to PCA analyses, nicotinamide (NCT) and proline …
  • A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid. [Journal Article]
    Int J Pharm. 2020 Jul 08; 586:119554.Champeau M, Jary D, … Vignoud S
  • Photodynamic therapy induced by protoporphyrin IX (PpIX) is widely used to treat precancerous skin lesions. The penetration depth of the prodrug 5-aminolevulinic acid (5-ALA) using topical application is currently limited, which hampers the production of PpIX in deep seated lesions. To enhance 5-ALA delivery in deep skin layers, a soluble microneedles patch (MN-patch) containing 5-ALA has been su…
  • Development of Low Dose Micro-tablets by High Shear Wet Granulation Process. [Journal Article]
    Int J Pharm. 2020 Jul 08 [Online ahead of print]Gupta S, Thool P, … Mitra B
  • Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU challenges associated with directly compressed low dose micro-tablets, in this study, high shear wet granulation (HSWG) process was evaluated to manufacture micro-t…
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