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20,874 results
  • The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy. [Journal Article]
  • JCJ Cachexia Sarcopenia Muscle 2019 Jul 08
  • Zhong X, Pons M, … Zimmers TA
  • CONCLUSIONS: Pancreatic adenocarcinoma tumours are a source of activin and elicit a systemic activin response in hosts. Human tumours express activins and related factors, while mortality correlates with tumour activin A expression. PDAC tumours also choreograph a systemic activin response that induces organ-specific and gene-specific expression of activin isoforms and muscle wasting. Systemic blockade of activin signalling could preserve muscle and prolong survival, while skeletal muscle-specific activin blockade was only protective for weight loss. Our findings suggest the potential and need for gene-specific and organ-specific interventions. Finally, development of more effective cancer cachexia therapy might require identifying agents that effectively and/or selectively inhibit autocrine vs. paracrine activin signalling.
  • Pretransplant Biopsy of Marginal Kidneys: Is It Necessary? [Journal Article]
  • TPTransplant Proc 2019; 51(5):1585-1589
  • Teixeira AC, Ferreira E, … Figueiredo A
  • CONCLUSIONS: Selection of kidneys based on histological findings may not influence the graft survival and implies a higher cold ischemia time. More data are necessary to provide insight into which clinical, histologic, and biochemical parameters are necessary for decision making on kidney acceptance.
  • Attitudes of Iranian students about organ donation: a qualitative study. [Journal Article]
  • BMBMC Med Ethics 2019 May 28; 20(1):36
  • Parsa P, Taheri M, … Shirahmadi S
  • CONCLUSIONS: Many factors influence the students' attitudes toward organ donation. Identification and explanation of these factors can help healthcare managers and policymakers for planning and improving the organ donation culture in the society.
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