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6,226 results
  • Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies. [Journal Article]
    Front Genet 2019; 10:1179Wang M, Bokros M, … Lee S
  • This year marks the 20th anniversary of the discovery that the nucleolus can temporarily immobilize proteins, a process known as nucleolar sequestration. This review reflects on the progress made to understand the physiological roles of nucleolar sequestration and the mechanisms involved in the immobilization of proteins. We discuss how protein immobilization can occur through a highly choreograp…
  • Mating precedes selective immune priming which is maintained throughout bumblebee queen diapause. [Journal Article]
    BMC Genomics 2019; 20(1):959Colgan TJ, Finlay S, … Carolan JC
  • CONCLUSIONS: Our results provide clear molecular evidence for the consequences and benefits of mating at the immune level as it precedes the selective increased abundance of antimicrobial peptides that are sustained throughout diapause. In addition, our results provide novel insights into the molecular mechanisms by which bumblebees prepare for, survive, and recover from diapause, insights that may have implications for our general understanding of these processes in other insect groups.
  • Bone secreted factors induce cellular quiescence in prostate cancer cells. [Journal Article]
    Sci Rep 2019; 9(1):18635Yu-Lee LY, Lee YC, … Lin SH
  • Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site(s) before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can occur years after prostatectomy, suggesting that bone may provide dormancy-inducing factors. To search for these factors, we prepared conditioned media (CM) from calvariae. Using live-cell imaging, we found that Calvaria…
  • Mechanisms of Metastatic Tumor Dormancy and Implications for Cancer Therapy. [Review]
    Int J Mol Sci 2019; 20(24)Neophytou CM, Kyriakou TC, Papageorgis P
  • Metastasis, a multistep process during which tumor cells disseminate to secondary organs, represents the main cause of death for cancer patients. Metastatic dormancy is a late stage during cancer progression, following extravasation of cells at a secondary site, where the metastatic cells stop proliferating but survive in a quiescent state. When the microenvironmental conditions are favorable, th…
  • Tumour Dormancy and Reawakening: Opportunities and Challenges. [Journal Article]
    Trends Cancer 2019; 5(12):762-765Boire A, Coffelt SB, … Weeraratna AT
  • Tumour dormancy presents challenges for clinical control and opportunities for scientific discovery. Current pictures of the mechanisms of tumour dormancy and reawakening remain incomplete. The Cancer Research UK's third Marshall Symposium explored tumour dormancy and reawakening in all their forms. In this forum article, we highlight the key challenges and opportunities discussed at this symposi…
  • The roles of latency-associated antigens in tuberculosis vaccines. [Review]
    Indian J Tuberc 2019; 66(4):487-491Yousefi Avarvand A, Khademi F, … Meshkat Z
  • Tuberculosis (TB) is a re-emerging disease and is caused by Mycobacterium tuberculosis (M. tuberculosis). TB is currently one of the leading causes of morbidity and mortality, worldwide. The only available vaccine against TB infection, Bacillus Calmette-Guérin (BCG), fails to adequately protect against reactivation of latent infections in adults. Furthermore, recently developed subunit vaccines, …
  • Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis. [Journal Article]
    BMC Genomics 2019; 20(1):942Maarsingh JD, Yang S, … Haydel SE
  • CONCLUSIONS: The M. smegmatis PrrAB two-component system regulates respiratory and oxidative phosphorylation pathways, potentially to provide tolerance against the dynamic environmental conditions experienced in its natural ecological niche. PrrAB positively regulates ATP levels during exponential growth, presumably through transcriptional activation of both terminal respiratory branches (cytochrome c bc1-aa3 and cytochrome bd oxidases), despite transcriptional repression of ATP synthase genes. Additionally, PrrAB positively regulates expression of the dormancy-associated dosR response regulator genes in an oxygen-independent manner, which may serve to fine-tune sensory perception of environmental stimuli associated with metabolic repression.
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