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(dornase)
276 results
  • Acetylcysteine for Patients Requiring Secretion Clearance: A Review of Guidelines [BOOK]
    Canadian Agency for Drugs and Technologies in Health: Ottawa (ON) Banerjee Srabani S McCormack Suzanne S BOOK
  • Mucus secretion clearance is a defense mechanism used by the lung to protect itself from pathogens and particles present in the inhaled air.1,2 Mucus traps pathogens and particles in inhaled air, and is usually cleared from the lungs and airways by airflow and ciliary hairs.2 Impaired mucous clearance results in abnormal lung function.3 Mucus is a viscoelastic gel-like substance and consists of g…
  • Bronchoscopic instillation of DNase to manage refractory lobar atelectasis in a lung cancer patient. [Case Reports]
    Ann Transl Med 2019; 7(15):363Assallum H, Song TY, … Harris K
  • Lobar atelectasis is a common complication in lung cancer. It can be caused by direct endobronchial tumorous seeding or indirectly by mucus plugs due to bacterial lung infections. Treatment is usually conservative, with or without therapeutic bronchoscopy. Dornase alfa is a recombinant human deoxyribonuclease I (rhDNase), an enzyme that selectively cleaves DNA, thus reducing mucous viscosity. rhD…
  • Acetylcysteine for Patients Requiring Mucous Secretion Clearance: A Review of Clinical Effectiveness and Safety [BOOK]
    Canadian Agency for Drugs and Technologies in Health: Ottawa (ON) Banerjee Srabani S McCormack Suzanne S BOOK
  • Mucus secretion clearance is a defense mechanism used by the lung to protect itself from pathogens and particles present in the inhaled air.1,2 Mucus traps pathogens and particles in inhaled air, and is usually cleared from the lungs and airways by airflow and ciliary hairs.2 Impaired mucous clearance results in abnormal lung function.3 Mucus is a viscoelastic gel-like substance and consists of g…
  • Plastic bronchitis: A case report. [Case Reports]
    Respir Med Case Rep 2019; 28:100876Grizales CL, González LM, … Fernández-Trujillo L
  • Plastic bronchitis is a rare and underdiagnosed disease characterized by the formation and expectoration of bronchial casts of amorphous material, which can be potentially fatal. It is more frequent in pediatric population. Symptoms can range from chronic cough and dyspnea to respiratory failure depending on the area of the compromised airway. Casts are classified as type I when constituted by in…
  • Aerosolized agents for airway clearance in cystic fibrosis. [Journal Article]
    Pediatr Pulmonol 2019; 54(6):858-864Southern KW, Clancy JP, Ranganathan S
  • The outlook for people with cystic fibrosis (CF) has improved considerably as a result of conventional therapies including aerosolized agents for airway clearance. These will continue to play a significant role in maintaining well-being and improving survival, even as newer agents emerge that correct the underlying CF defect. In this review, we explore the evidence supporting the use of dornase a…
  • Inhaled medications in cystic fibrosis beyond antibiotics. [Journal Article]
    Minerva Pediatr 2019; 71(4):371-375Sepe A, Villella VR, … Raia V
  • Structural lung disease begins very early in children with cystic fibrosis (CF), often in the first three months of life. Inhaled medications represent an attractive therapeutic approach in CF that are routinely used as early intervention strategies. Two aerosolized solutions, hypertonic saline and dornase alfa, have significant potential benefits by improving mucociliary clearance, with minimal …
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