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273 results
  • Plastic bronchitis: A case report. [Case Reports]
    Respir Med Case Rep 2019; 28:100876Grizales CL, González LM, … Fernández-Trujillo L
  • Plastic bronchitis is a rare and underdiagnosed disease characterized by the formation and expectoration of bronchial casts of amorphous material, which can be potentially fatal. It is more frequent in pediatric population. Symptoms can range from chronic cough and dyspnea to respiratory failure depending on the area of the compromised airway. Casts are classified as type I when constituted by in…
  • Aerosolized agents for airway clearance in cystic fibrosis. [Journal Article]
    Pediatr Pulmonol 2019; 54(6):858-864Southern KW, Clancy JP, Ranganathan S
  • The outlook for people with cystic fibrosis (CF) has improved considerably as a result of conventional therapies including aerosolized agents for airway clearance. These will continue to play a significant role in maintaining well-being and improving survival, even as newer agents emerge that correct the underlying CF defect. In this review, we explore the evidence supporting the use of dornase a…
  • Inhaled medications in cystic fibrosis beyond antibiotics. [Journal Article]
    Minerva Pediatr 2019; 71(4):371-375Sepe A, Villella VR, … Raia V
  • Structural lung disease begins very early in children with cystic fibrosis (CF), often in the first three months of life. Inhaled medications represent an attractive therapeutic approach in CF that are routinely used as early intervention strategies. Two aerosolized solutions, hypertonic saline and dornase alfa, have significant potential benefits by improving mucociliary clearance, with minimal …
  • Timing of dornase alfa inhalation for cystic fibrosis. [Meta-Analysis]
    Cochrane Database Syst Rev 2018; 11:CD007923Dentice R, Elkins M
  • CONCLUSIONS: The current evidence derived from a small number of participants does not indicate that inhalation of dornase alfa after airway clearance techniques is more or less effective than the traditional recommendation to inhale nebulised dornase alfa 30 minutes prior to airway clearance techniques, for most outcomes. For children with well-preserved lung function, inhalation before airway clearance may be more beneficial for small airway function than inhalation after. However, this result relied on a measure with high variability and trials with variable follow-up. In the absence of strong evidence to indicate that one timing regimen is better than another, the timing of dornase alfa inhalation can be largely based on pragmatic reasons or individual preference with respect to the time of airway clearance and time of day. Further research is warranted.
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