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8,799 results
  • Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions. [Review]
    Int J Mol Sci 2020; 21(4)Hosoi K, Yao C, … Akamatsu T
  • AQP5 plays an important role in the salivary gland function. The mRNA and protein for aquaporin 5 (AQP5) are expressed in the acini from embryonic days E13-16 and E17-18, respectively and for entire postnatal days. Ligation-reopening of main excretory duct induces changes in the AQP5 level which would give an insight for mechanism of regeneration/self-duplication of acinar cells. The AQP5 level i…
  • Improving Bioinformatics Prediction of microRNA Targets by Ranks Aggregation. [Journal Article]
    Front Genet 2019; 10:1330Quillet A, Saad C, … Dubessy C
  • microRNAs are noncoding RNAs which downregulate a large number of target mRNAs and modulate cell activity. Despite continued progress, bioinformatics prediction of microRNA targets remains a challenge since available software still suffer from a lack of accuracy and sensitivity. Moreover, these tools show fairly inconsistent results from one another. Thus, in an attempt to circumvent these diffic…
  • Adherens junction remodelling during mitotic rounding of pseudostratified epithelial cells. [Journal Article]
    EMBO Rep 2020; :e49700Aguilar-Aragon M, Bonello TT, … Thompson BJ
  • Epithelial cells undergo cortical rounding at the onset of mitosis to enable spindle orientation in the plane of the epithelium. In cuboidal epithelia in culture, the adherens junction protein E-cadherin recruits Pins/LGN/GPSM2 and Mud/NuMA to orient the mitotic spindle. In the pseudostratified columnar epithelial cells of Drosophila, septate junctions recruit Mud/NuMA to orient the spindle, whil…
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