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1,758 results
  • Prolonged acidosis is a feature of SGLT2i-induced euglycaemic diabetic ketoacidosis. [Journal Article]
    Endocrinol Diabetes Metab Case Rep 2019; 2019Rafey MF, Butt A, … Finucane FM
  • We describe two cases of SGLT2i-induced euglycaemic diabetic ketoacidosis, which took longer than we anticipated to treat despite initiation of our DKA protocol. Both patients had an unequivocal diagnosis of type 2 diabetes, had poor glycaemic control with a history of metformin intolerance and presented with relatively vague symptoms post-operatively. Neither patient had stopped their SGLT2i pre…
  • Revisiting the Pharmacodynamic Uroselectivity of α 1-Adrenergic Receptor Antagonists. [Journal Article]
    J Pharmacol Exp Ther 2019; 371(1):106-112Quaresma BMCS, Pimenta AR, … Noël F
  • α1-Adrenoceptor (AR) antagonists are widely used for the relief of urinary retention secondary to benign prostatic hyperplasia (BPH). While the five Food and Drug Administration-approved α 1-AR antagonists (terazosin, doxazosin, alfuzosin, tamsulosin, and silodosin) share similar efficacy, they differ in tolerability, with reports of ejaculatory dysfunction. The aim of the present work was to rev…
  • Structure-based analysis of curcumin and conventionaldrugs targeting tumor-inducing protein PHF20. [Journal Article]
    Bioinformation 2018; 14(9):477-481Agrawal V, Mishra A, … Akhileshwar KS
  • Recently, the PHF20 has been reported as tumor inducer protein by suppressing the activity of tumor suppressor protein p53. Conventional drugs (albendazole, doxazosin, and propranolol) are used for treatment of cancer causing side effect. The secondary metabolite curcumin is employed in various diseases treatment including cancer. The present study is to explore curcumin in comparison to selected…
  • Prostate Transition Zone Fibrosis Is Associated with Clinical Progression in the MTOPS Study. [Journal Article]
    J Urol 2019; :101097JU0000000000000385Macoska JA, Uchtmann KS, … Ricke WA
  • CONCLUSIONS: Fibrotic changes in the prostate transition zone are associated with an increased risk of clinical progression in men treated with doxazosin plus finasteride. Antifibrotic therapeutics might provide a new treatment approach in men with lower urinary tract dysfunction who do not respond to current medical treatment approaches.
  • Bilateral pheochromocytoma after kidney transplantation in neurofibromatosis type 1. [Journal Article]
    Endocrinol Diabetes Metab Case Rep 2019; 2019de Miguel V, Paissan A, … Fainstein-Day P
  • We present the case of a 25-year-old male with a history of neurofibromatosis type 1 and bilateral pheochromocytoma 4 years after kidney transplantation that was successfully treated with simultaneous bilateral posterior retroperitoneoscopic adrenalectomy. Learning points: Hypertensive patients with NF1 should always be screened for pheochromocytoma. Pheochromocytoma is rarely associated with tra…
  • Prospects for pharmacotherapies to treat alcohol use disorder: an update on recent human studies. [Journal Article]
    Curr Opin Psychiatry 2019; 32(4):255-265Farokhnia M, Browning BD, Leggio L
  • CONCLUSIONS: There is a critical need to increase the armamentarium of medications for AUD. Human laboratory studies may help screen and prioritize promising targets and compounds before running large clinical trials. Given the complexity of AUD and the heterogeneity of afflicted patients, future studies should also investigate potential moderators and predictors of response to each pharmacological intervention.
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