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1,424 results
  • Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine. [Journal Article]
    Pharmacol Res Perspect 2019; 7(4):e00499Nakamura T, Hiraoka K, … Okamura N
  • Some histamine H1 receptor (H1R) antagonists induce adverse sedative reactions caused by blockade of histamine transmission in the brain. Desloratadine is a second-generation antihistamine for treatment of allergic disorders. Its binding to brain H1Rs, which is the basis of sedative property of antihistamines, has not been examined previously in the human brain by positron emission tomography (PE…
  • Sex differences in the pharmacology of itch therapies-a narrative review. [Review]
    Curr Opin Pharmacol 2019; 46:122-142Schmid Y, Navarini A, … Mueller SM
  • CONCLUSIONS: Our review supports previous reports that sex is of importance in the pharmacokinetics and /-dynamics of several drugs used to treat itch although those drugs were mostly evaluated for non-itch indications. However, the results are limited by methodological limitations evident in most studies such as underrepresentation of women in clinical trials. This emphasises the need to study the impact of sex (and gender) in future itch trials to yield better outcomes and prevent ADRs in both sexes.
  • StatPearls: Doxepin [BOOK]
    StatPearls Publishing: Treasure Island (FL) Almasi Anasheh A Meza Carlos E. CE Kern Medical Center BOOK
  • Doxepin is a tricyclic antidepressant that was FDA approved in 1969 to treat major depressive disorder. Doxepin was primarily approved to treat depression; however, it can also target multiple receptors and has proven beneficial in the treatment of other disorders. Doxepin displays antagonist effects on alpha-adrenergic, muscarinic, and histaminic receptors. With such a wide variety of receptors …
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