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2,783 results
  • Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting. [Review]
    Saudi J Anaesth 2019 Jul-Sep; 13(3):231-236Ngo AL, Orhurhu V, … Urman RD
  • In this review, we evaluate recent literature on use of ER granisetron in clinical practice as compared with current antiemetics and describe its potential uses for perioperative PONV prophylaxis and treatment. Recent literature was evaluated on ER granisetron use compared with currently used antiemetic agents ondansetron, droperidol, metoclopramide, promethazine, and dexamethasone with a focus o…
  • A randomised controlled trial of the pectoral nerves-2 (PECS-2) block for radical mastectomy. [Journal Article]
    Anaesthesia 2019; 74(10):1277-1281Al Ja'bari A, Robertson M, … Albrecht E
  • We randomly allocated 50 women scheduled for radical mastectomy to pectoral nerves-2 (PECS-2) block (n = 25) or no block (n = 25), 20 and 22 of whom we analysed for the primary outcome of a cumulative 24-h postoperative morphine dose. We gave intra-operative sufentanil, magnesium, dexamethasone and droperidol. Participants received regular postoperative paracetamol, ibuprofen and patient-controll…
  • The effect of anti-emetic drugs on rat embryonic heart activity. [Journal Article]
    Reprod Toxicol 2019; 87:140-145Ritchie HE, Huss IB, Webster WS
  • Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult …
  • Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization. [Journal Article]
    Int J Mol Sci 2019; 20(7)Wouters E, Marín AR, … Stove C
  • Dopamine D₂ receptors (D₂R) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor homodimers might lead to a better understanding of the critical role played by these complexes in physiological and pathological conditions. Whereas…
  • Impact of intracranial hypertension on the short-term prognosis in dogs undergoing brain tumor surgery. [Journal Article]
    J Vet Med Sci 2019; 81(8):1205-1210Seki S, Teshima K, … Yamaya Y
  • The present study used data from anesthetic records to analyze variables of intracranial pressure (ICP) during brain tumor surgery or in the early postoperative period as prognostic indicators in dogs. Data from 17 dogs which were scheduled to undergo elective craniotomy for brain tumor surgery from 2009 to 2012 were included. Of these, five (29.4%) died during 14 days after the surgery because o…
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