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5,568,989 results
  • Thrombolytics for Acute Myocardial Infarction in a Prehospital Setting: A Review of Comparative Safety, and Guidelines [BOOK]
    Canadian Agency for Drugs and Technologies in Health: Ottawa (ON) Marchand Dave K. DK Farrah Kelly K BOOK
  • Myocardial infarction is an acute coronary syndrome in which the heart muscle undergoes injury due to ischemia (lack of blood supply).1 About 63,200 adult Canadians had a first myocardial infarction in the 2012–2013 fiscal year.2 Older Canadians are disproportionately affected, causing major morbidity and mortality, with an estimated 630,203 years of life lost3 and 30,894 years lived with disabil…
  • Sodium-Glucose Cotransporter-2 Inhibitors: Lack of a Complete History Delays Diagnosis. [Journal Article]
    Ann Intern Med 2019; 171(6):421-426Leslie BR, Gerwin LE, Taylor SI
  • On 15 May 2015, the U.S. Food and Drug Administration (FDA) warned that administration of sodium-glucose cotransporter-2 (SGLT2) inhibitors could lead to ketoacidosis in patients with diabetes mellitus. This announcement came more than 2 years after the FDA's first approval of an SGLT2 inhibitor, although the phenomenon had been known for more than 125 years. Luminaries of diabetes research (incl…
  • New dimensions in the field of antimalarial research against malaria resurgence. [Review]
    Eur J Med Chem 2019; 181:111353Narula AK, Azad CS, Nainwal LM
  • Malaria is a life threatening disease caused by microscopic parasites called Plasmodium that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium parasite is responsible to cause malaria in human beings and is transmitted by bite of Anopheles species mosquitoes. Resurgence of malaria towards the end of 20th Century is due to failure of its eradication completely. Par…
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