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5,752,139 results
  • Impact of integrated clinical decision support systems in the management of pediatric acute kidney injury: a pilot study. [Journal Article]
    Pediatr Res. 2020 Jul 03 [Online ahead of print]Menon S, Tarrago R, … Yonekawa K
  • CONCLUSIONS: AKI remains under-recognized. CDS (electronic alerts and SCP) improve recognition and allow early intervention. This may improve long-term outcomes, but larger studies are needed.Acute kidney injury can cause significant morbidity and mortality. It is under-recognized in children.Clinical decision support can be used to leverage existing data in the electronic health record to improve AKI recognition.This study demonstrates the use of a novel, electronic health record-linked, clinical decision support tool to improve the recognition of AKI and guideline-adherent clinical care.
  • Language network reorganization before and after temporal lobe epilepsy surgery. [Journal Article]
    J Neurosurg. 2020 Jul 03 [Online ahead of print]Foesleitner O, Sigl B, … Kasprian G
  • CONCLUSIONS: Functional connectivity analysis contributes unique insight into bihemispheric remodeling processes of language networks after epilepsy surgery, with characteristic findings in left and right TLE. Presurgical contralateral language recruitment is associated with better postsurgical language outcome in left and right TLE.
  • Socioeconomic consequences of drug-resistant epilepsy in an adult cohort from southern India. [Journal Article]
    Epilepsy Behav. 2020 Jun 30; 110:107173.Chatterjee A, Nair R, … Radhakrishnan K
  • CONCLUSIONS: In addition to high seizure burden, DRE adversely affects the pursuit of higher education, employment, and marriage. Besides the direct cost of epilepsy, these issues augment both the patient and the caregiver's liability. Socioeconomic consequences of DRE are widely prevalent in developing countries, and this study highlights the need to address them.
  • Graphene-like boron carbide monolayer as an electronic and work function-type sensor for dopamine drug. [Journal Article]
    J Mol Graph Model. 2020 May 15; 99:107644.Ding W, Zhang X, … Wu L
  • The electronic response of both pristine and Al-doped BC3 nanosheets toward 3, 4-dihydroxyphenyl ethylamine, i.e. dopamine (DA) was studied through density functional theory. Based on the adsorption energy the tendency of pristine BC3 toward DA drug insignificant and also after adsorption of DA drug the electronic properties of BC3 were changed negligibly. While doping the sheet by Al significant…
  • Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides. [Journal Article]
    Eur J Med Chem. 2020 Jun 06; 201:112477.Demchenko S, Lesyk R, … Demchenko A
  • Novel 1-aryl-3-biphenyl-4-yl-3-hydroxy-2,5,6,7,8,9-hexahydro-3H-imidazo[1,2-a]azepin-1-ium bromides and their 2,5-dehydrogenated analogues were designed and synthesized using a reaction of aryl-(4,5,6,7-tetrahydro-3H-azepin-2-yl)-amines with 1-biphenyl-4-yl-2-bromoethanone. Among the 16 novel compounds 5 derivatives displayed in vitro antimicrobial activity; while three of them showed promising a…
  • Drug repurposing: Discovery of troxipide analogs as potent antitumor agents. [Journal Article]
    Eur J Med Chem. 2020 Jun 26; 202:112471.Lu N, Huo JL, … Liu HM
  • Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clinical drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three ca…
  • Substance use disorders among youth with chronic physical illness. [Journal Article]
    Addict Behav. 2020 Jun 23; 110:106517.Luther AWM, Reaume SV, … Ferro MA
  • This study estimated prevalence of substance use disorder in youth with chronic physical illness; quantified magnitudes of association between different chronic physical illnesses with substance use disorder; and, tested whether mental disorder moderates these associations. Data come from 6,377 individuals aged 15-30 years in the Canadian Community Health Survey-Mental Health. Alcohol, cannabis, …
  • Prognostic indicators for gastrointestinal stromal tumors: a review. [Review]
    Transl Oncol. 2020 Jun 26; 13(10):100812.Zhang H, Liu Q
  • Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main prognostic factors are the mitotic rate, tumor size and tumor site. In addition, t…
  • Taking advantage of cellular uptake of ferritin nanocages for targeted drug delivery. [Review]
    J Control Release. 2020 Jun 30 [Online ahead of print]Tesarova B, Musilek K, … Heger Z
  • The search for ideal nanocarrier, which could be rapidly translated to clinical practice, isstill ongoing over the past few decades. However, many reviews are focused onimportant properties of ideal nanocarrier, including long circulation, high internalization efficiency ofadrug, surface charge of nanocarrier or the ability to encapsulate high amount of a drug. Indeed, theability to encapsulate w…
  • Controlled drug delivery for alopecia: A review. [Review]
    J Control Release. 2020 Jul 01 [Online ahead of print]Shefrin S, Kaladhar K
  • Alopecia or hair loss is a benign treatable disorder which, over time, becomes chronic, affecting a significant fraction of the population that affects the patient's self-esteem and quality of life. The existing treatment regimen for alopecia is inadequate for drug delivery directly to hair follicles to result in continuous hair growth. The challenges are due to multiple-dose regimes and patient …
  • Oral hydrophilic matrices having non uniform drug distribution for zero-order release: A literature review. [Review]
    J Control Release. 2020 Jun 30 [Online ahead of print]Cerea M, Maroni A, … Gazzaniga A
  • Oral hydrophilic matrices for prolonged release mostly show a decrease in the rate of drug release over time, owing to the increasing length of the diffusional path and progressive reduction of the area at the interface between glassy and rubbery matrix. In addition, burst effect may also occur due to the fraction of drug present on the surface of the system, which is released when the external p…
  • CORDITE: The Curated CORona Drug InTERactions Database for SARS-CoV-2. [Journal Article]
    iScience. 2020 Jun 20; 23(7):101297.Martin R, Löchel HF, … Heider D
  • Since the outbreak in 2019, researchers are trying to find effective drugs against the SARS-CoV-2 virus based on de novo drug design and drug repurposing. The former approach is very time consuming and needs extensive testing in humans, whereas drug repurposing is more promising, as the drugs have already been tested for side effects, etc. At present, there is no treatment for COVID-19 that is cl…
  • Mucoadhesive zein/beta-cyclodextrin nanoparticles for the buccal delivery of curcumin. [Journal Article]
    Int J Pharm. 2020 Jun 30 [Online ahead of print]Esposito D, Conte C, … Quaglia F
  • Herein, we have developed sprayable dispersions of mucoadhesive nanoparticles (NPs) made of zein, a hydrophobic plant-based protein, for the buccal delivery of curcumin (CUR), a poorly water-soluble polyphenol. NPs were prepared by the liquid-liquid dispersion method using an antisolvent water solution without or with beta-cyclodextrin (CD). NPs were spherical with a monomodal size distribution, …
  • Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats. [Journal Article]
    Eur J Pharmacol. 2020 Jun 30 [Online ahead of print]Zirak MR, Karimi G, … Mehri S
  • Hemorrhagic cystitis is one of the most important complications of cyclophosphamide, a drug widely used in cancer chemotherapy and bone marrow transplantation. 5-HT3 antagonists are anti-emetic agents and have been shown to have notable anti-inflammatory and antioxidant properties. This study was designed to investigate the possible protective effects of tropisetron against cyclophosphamide-induc…
  • Virtual screening based on molecular docking of possible inhibitors of Covid-19 main protease. [Journal Article]
    Microb Pathog. 2020 Jun 30 [Online ahead of print]Marinho EM, Batista de Andrade Neto J, … Nobre Júnior HV
  • Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and that has now been declared a global pandemic by the World Health Organization. Thus, there is an urgent need to develop effective therapies and vaccines against this disease. In this context, this study aimed to evaluate in silico the molecular interactions of drugs with therapeutic indications for treatment of…
  • Sodium valproate (VPA) interactions with DNA and histones. [Journal Article]
    Int J Biol Macromol. 2020 Jun 30 [Online ahead of print]de Campos Vidal B, Mello MLS
  • Valproic acid/sodium valproate (VPA) constitutes a widely prescribed drug for the treatment of seizure disorders and is a well-known epigenetic agent, inducing the acetylation of histones and affecting the methylation status of DNA and histones, with consequences on gene expression. Because this drug has been recently reported to exert affinity for histone H1, and to a minor degree for DNA, in th…
  • Senna plant generates reactive oxygen species (ROS) and induces apoptosis in Hymenolepis diminuta. [Journal Article]
    Mol Biochem Parasitol. 2020 Jun 30 [Online ahead of print]Roy S, Joardar N, … Lyndem LM
  • Like mammalian cells, helminth parasites are equipped with an array of enzymatic anti-oxidant system which has an adaptive strategy to cope up with several conditions of stress that arise from host immune response or drug treatment. Earlier, we had reported that three species of Senna, viz. S. alata, S. alexandrina and S. occidentalis leaf extracts caused severe morphological and biochemical alte…
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