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3,425 results
  • Adapterama II: universal amplicon sequencing on Illumina platforms (TaggiMatrix). [Journal Article]
    PeerJ 2019; 7:e7786Glenn TC, Pierson TW, … Faircloth BC
  • Next-generation sequencing (NGS) of amplicons is used in a wide variety of contexts. In many cases, NGS amplicon sequencing remains overly expensive and inflexible, with library preparation strategies relying upon the fusion of locus-specific primers to full-length adapter sequences with a single identifying sequence or ligating adapters onto PCR products. In Adapterama I, we presented universal …
  • RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies. [Review]
    Cancers (Basel) 2019; 11(10)Toma M, Sullivan-Reed K, … Skorski T
  • Alterations in DNA repair systems play a key role in the induction and progression of cancer. Tumor-specific defects in DNA repair mechanisms and activation of alternative repair routes create the opportunity to employ a phenomenon called "synthetic lethality" to eliminate cancer cells. Targeting the backup pathways may amplify endogenous and drug-induced DNA damage and lead to specific eradicati…
  • Extending the Limit of Measurement for Dual H and O Isotope Ratios Using Thermolysis. [Journal Article]
    Anal Chem 2019Van Hale RJ, Holder PW, … Frew RD
  • Hydrogen and oxygen isotope ratios are of use to determine the origin of matter. Thermolysis is used to convert matter to H2 and CO gases, which are the respective substrates for measurement of these two isotope ratios, using isotope ratio mass spectrometry (IRMS). This work was done in response to the need for analysis of small invasive insects, requiring a decrease in the limit of measurement f…
  • Anti-aging and Sunscreens: Paradigm Shift in Cosmetics. [Review]
    Adv Pharm Bull 2019; 9(3):348-359Shanbhag S, Nayak A, … Nayak UY
  • Skin, being one of the vital organs and a protective barrier needs to be pampered and taken care of from early childhood. It is the most visible and the widest exposed organ and by far reflects the general health condition and the aging process in humans. Both intrinsic and extrinsic factors contribute to this complex biological process of skin aging. In recent times, skin health and its beauty i…
  • Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management. [Journal Article]
    Annu Rev Cell Dev Biol 2019; 35:501-521Jin Y, Zheng B
  • The dual leucine zipper-bearing kinase (DLK) and leucine zipper-bearing kinase (LZK) are evolutionarily conserved MAPKKKs of the mixed-lineage kinase family. Acting upstream of stress-responsive JNK and p38 MAP kinases, DLK and LZK have emerged as central players in neuronal responses to a variety of acute and traumatic injuries. Recent studies also implicate their function in astrocytes, microgl…
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