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(dysfunction)
1,998,949 results
  • Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation. [Journal Article]
    Redox Biol 2019; 26:101300Mayorov V, Uchakin P, … Dikalov S
  • Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens. Inflammation produces highly reactive dicarbonyl lipid peroxidation products such as isolevuglandins which covalently modify and cross-link proteins via lysine residues. Mitochondrial dysfunction has been associated…
  • Aging sensitizes male mice to cognitive dysfunction induced by central HIV-1 gp120. [Journal Article]
    Exp Gerontol 2019; :110694Sparkman N, Buchanan JB, … Burton MD
  • Although highly active antiretroviral therapy has led to improved prognosis and alleviation of some HIV-related disease complications, it has not provided complete protection against HIV-associated dementia. As the population of persons living with HIV grows older and aged persons represent a significant number of new infections, it is important to understand how HIV may affect the aged brain. In…
  • Using Yoda-1 to mimic laminar flow in vitro: a tool to simplify drug testing. [Journal Article]
    Biochem Pharmacol 2019Davies JE, Lopresto D, … Harper MT
  • The endothelium is an attractive drug target and an important site of adverse drug reactions. Endothelial dysfunction is strongly associated with inflammation and contributes to drug-induced cardiovascular toxicity. Endothelial cells in the circulation are exposed to haemodynamic forces including shear stress. Including shear stress may improve future endothelial cell drug discovery or toxicity s…
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