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Unbound Medicine.
(dysfunction)
2,082,667 results
  • Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest. [Journal Article]
    Prostaglandins Leukot Essent Fatty Acids. 2020 May 23; 159:102138.Chen PY, Wu CY, … Lin HW
  • Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrime…
  • Microorganisms associated to thyroid autoimmunity. [Review]
    Autoimmun Rev. 2020 Jul 11 [Online ahead of print]Baltazar JYNC, Vega ES
  • Autoimmune thyroid diseases are a group of diseases characterized by a dysfunction of the immune system concerning the thyroid gland, associated with hypothyroidism or hyperthyroidism. The thyroid gland autoimmunity has been recognized as multifactorial. It has been reported that microorganisms may play a role on the pathogenesis of Hashimoto's thyroiditis and Graves´ disease. These could explain…
  • Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat. [Journal Article]
    Life Sci. 2020 Jul 11 [Online ahead of print]Jia G, Meng Z, … Wang Y
  • Since an outbreak of vaping-related deaths in the US has been reported as a public health crisis, the cardiovascular safety of nicotine nowadays receives increasing attention due to use of tobacco cigarette alternatives, such as electronic cigarettes. However, whether and how nicotine contributes to cardiac detrimental effects are in great controversy, especially less understood in young adult po…
  • Experimental hypothyroidism raises brain kynurenic acid - Novel aspect of thyroid dysfunction. [Journal Article]
    Eur J Pharmacol. 2020 Jul 11 [Online ahead of print]Tomczyk T, Urbańska EM
  • Hypothyroidism frequently manifests with altered mood and disturbed cognition. Kynurenic acid may influence cognition through antagonism of N-methyl-d-aspartate receptors (NMDA) and α7 nicotinic receptors. In here, thyroid hormones effects on kynurenic acid synthesis in rat cortical slices and on kynurenine aminotransferases (KATs) activity in semi-purified cortical homogenates were studied. Furt…
  • Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis. [Journal Article]
    ESC Heart Fail. 2020 Jul 14 [Online ahead of print]Tschöpe C, Van Linthout S, … Pappritz K
  • CONCLUSIONS: Early intervention with the MRA eplerenone modulates the acute host and defence reaction and prevents cardiac disease progression in experimental CVB3-induced myocarditis without aggravation of viral load. The findings advocate for an initiation of therapy of viral myocarditis as early as possible, even before the onset of inflammation-induced myocardial dysfunction. This may also have implications for coronavirus disease-19 therapy.
  • Genetic Variants in Children with Chronic Respiratory Diseases. [Journal Article]
    Pediatr Pulmonol. 2020 Jul 14 [Online ahead of print]Alsamri MT, Alabdouli A, … Souid AK
  • Founder mutations and autosomal recessive disorders are common in the Arabian Peninsula due to frequent consanguineous marriages. As a result, the pulmonary service at Tawam Hospital (Al Ain, UAE) routinely requests genetic testing for children with persistent (unexplained) respiratory problems. The main purpose of this report was to underscore the usefulness of these tests. Ten children with sev…
  • Bioinformatic analysis of key genes and pathways in hashimoto thyroiditis tissues. [Journal Article]
    Biosci Rep. 2020 Jul 14 [Online ahead of print]Zheng L, Dou XJ, … Zheng XH
  • Hashimoto thyroiditis (HT) is one of the most common autoimmune diseases, and the incidence of HT continues to increase. Long-term, uncontrollable HT results in thyroid dysfunction and even increases carcinogenesis risks. Since the origin and development of HT involve many complex immune processes, there is no effective therapy for HT on a pathogenesis level. Although bioinformatics analysis has …
  • Olfactory Dysfunction in COVID-19 Patients: Prevalence and Prognosis for Recovering Sense of Smell. [Journal Article]
    Otolaryngol Head Neck Surg. 2020 Jul 14 [Online ahead of print]D'Ascanio L, Pandolfini M, … Di Stadio A
  • While olfactory dysfunction associated with coronavirus disease 2019 (COVID-19) has attracted considerable interest, few studies have tracked outcomes at serial time points or beyond 2 weeks. Furthermore, data are conflicting regarding whether COVID-19 severity correlates with degree of olfactory dysfunction. This prospective case-control study analyzed prevalence and severity of subjective loss …
  • Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-ε4 Carriers. [Journal Article]
    Cereb Cortex. 2020 Jul 14 [Online ahead of print]Fortel I, Korthauer LE, … Leow A
  • Synaptic dysfunction is hypothesized to be one of the earliest brain changes in Alzheimer's disease, leading to "hyperexcitability" in neuronal circuits. In this study, we evaluated a novel hyperexcitation indicator (HI) for each brain region using a hybrid resting-state structural connectome to probe connectome-level excitation-inhibition balance in cognitively intact middle-aged apolipoprotein …
  • Increased behavioral inhibition trait and negative stress coping in non-rapid eye movement parasomnias. [Journal Article]
    J Clin Sleep Med. 2020 Jul 14 [Online ahead of print]Ramm M, Urbanek A, … Heidbreder A
  • CONCLUSIONS: The results suggest subclinical behavioral abnormalities in patients with NREM parasomnias. Such traits might trigger maladaptive emotion regulation processes related to a relative PCC volume increase. The findings encourage further longitudinal studies on this topic, which can provide insights into the causal relations underlying the PCC volume - behavior correlation. Such future studies will have a more direct implication on the clinical management of patients with NREM parasomnias.
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