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49,219 results
  • [Signaling pathways controlling skeletal muscle mass]. [Journal Article]
    Sheng Li Xue Bao 2019; 71(4):671-679Zheng LF, Chen PJ, Xiao WH
  • The skeletal muscle mass accounts for more than 40% of the body weight of healthy adults. The skeletal muscle not only plays an important role in physical activities but also affects the function of other organs as a secretory organ secreting multiple muscle factors. Therefore, it is important to maintain the normal quantity and function of skeletal muscle. Skeletal muscle mass is the basis of sk…
  • Current perspectives in Bietti crystalline dystrophy. [Journal Article]
    Clin Ophthalmol 2019; 13:1379-1399García-García GP, Martínez-Rubio M, … Escribano J
  • Bietti crystalline dystrophy (BCD) is a rare-inherited disease caused by mutations in the CYP4V2 gene and characterized by the presence of multiple shimmering yellow-white deposits in the posterior pole of the retina in association with atrophy of the retinal pigment epithelium (RPE) and chorioretinal atrophy. The additional presence of glittering dots located at the corneal limbus is also a freq…
  • Safety and Efficacy of Treatment for Scolios Is Secondary to Spinal Muscular Atrophy Fused to Lumbar 5 Level. [Journal Article]
    Spine Surg Relat Res 2018; 2(4):294-298Takei S, Miyagi M, … Takaso M
  • CONCLUSIONS: The correction rate of scoliosis in SMA patients with posterior spinal fusion and instrumentation to the L5 level was acceptable, and no complications occurred. Scoliosis associated with SMA was more rigid and severer than scoliosis associated with Duchenne muscular dystrophy. Correction rates of the Cobb angle and PO in SMA patients with instrumentation to L5 were similar to those in SMA patients with instrumentation to the sacrum or pelvis. Correction loss of PO was greater in patients with high preoperative PO than in those with low preoperative PO. Instrumentation and fusion to L5 for scoliosis in patients with SMA seems safe and effective, except in cases of high preoperative PO.
  • Perioperative Complications in Posterior Spinal Fusion Surgery for Neuromuscular Scoliosis. [Journal Article]
    Spine Surg Relat Res 2018; 2(4):278-282Matsumoto M, Miyagi M, … Takaso M
  • CONCLUSIONS: Compared with the previous findings of the perioperative complication rate (45%-74%) for NMS, the complication rate was remarkably low in this case series. Because of advances in medical skills, including anesthesia and surgical instruments, surgery for NMS appears to be safe. However, patients with NMS with complications demonstrated severe restrictive ventilatory impairment preoperatively. Therefore, we should be vigilant for perioperative pulmonary complications especially in patients with NMS and preoperative severe restrictive ventilatory impairment.
  • The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes. [Journal Article]
    Neurobiol Aging 2019; 82:88-101Hansra GK, Popov G, … Cullen KM
  • Cerebrovascular pathology is common in aging and Alzheimer's disease (AD). The microvasculature is particularly vulnerable, with capillary-level microhemorrhages coinciding with amyloid beta deposits in senile plaques. In the current analysis, we assessed the relationship between cerebral microvessels and the neuritic component of the plaque in cortical and hippocampal 50- to 200-μm sections from…
  • Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy. [Journal Article]
    Sci Rep 2019; 9(1):12167Hathout Y, Liang C, … McDonald C
  • Extensive biomarker discoveries for DMD have occurred in the past 7 years, and a vast array of these biomarkers were confirmed in independent cohorts and across different laboratories. In these previous studies, glucocorticoids and age were two major confounding variables. In this new study, using SomaScan technology and focusing on a subset of young DMD patients who were not yet treated with glu…
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