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250 results
  • Exploring the carbohydrate-binding ability of Canavalia bonariensis lectin in inflammation models. [Journal Article]
    J Mol Recognit. 2020 Jul 09 [Online ahead of print]Cavada BS, Silva MTL, … Assreuy AMS
  • Lectins are a group of proteins of non-immune origin recognized for their ability to bind reversibly to carbohydrates. Researchers have been intrigued by oligosaccharides and glycoconjugates for their involvement as mediators of complex cellular events and then many biotechnological applications of lectins are based on glycocode decoding and their activities. Here, we report a structural and biol…
  • Paratrygon aiereba irradiated anti-mucus serum reduce edematogenic activity induced in experimental model. [Journal Article]
    Toxicon. 2020 Apr 30; 178:13-19.Coelho Thomazi GO, da Costa A, … do Nascimento N
  • Accidents by freshwater stingrays are common in northern Brazil, there is no specific therapy for high morbidity and local tissue destruction. The irradiation of venoms and toxins by ionizing radiation has been used to produce appropriate immunogens for the production of antisera. We planned to study the efficacy of stinging mucus irradiation in the production of antisera, with serum neutralizati…
  • Pharmacological Characterization of Mouse Hind Paw Edema Induced by Parachartergus fraternus Venom. [Journal Article]
    Inflammation. 2019 Dec; 42(6) Araujo Isaias Muller J, Mortari MR, … Toffoli-Kadri MC
  • Stings from the wasp Parachartergus fraternus occur throughout Latin America, and edema followed by pain is the main symptom presented by victims. This often limited inflammatory event has not been characterized for this species. In this work, we identified the mechanisms and possible mediators involved in this response. P. fraternus venom (100, 200, and 400 μg/kg) was injected into the hind paws…
  • Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice. [Journal Article]
    Eur J Pharmacol. 2019 Sep 05; 858:172460.Norões MM, Santos LG, … André E
  • Contact dermatitis is a very common inflammatory reaction in the skin, causing not only aesthetic problems but also loss functionality at work. The molecular mechanisms of contact dermatitis induced by chemical irritants are still unclear. Considering that transient receptor potential channels (TRP) may induce neurogenic inflammation and the exacerbation of inflammatory responses, here we investi…
  • Analgesic and anti-inflammatory effects of Caryocar brasiliense. [Journal Article]
    Antiinflamm Antiallergy Agents Med Chem. 2019 Apr 08 [Online ahead of print]Jorge A, Leitão MM, … Kassuya CAL
  • Analgesic and anti-inflammatory effects of Caryocar brasiliense Abstract Caryocar brasiliense, popularly known as pequi, is widely distributed in the Amazon rainforest and Brazilian savannah. The fruit obtained from pequi is used in cooking and has folk use as an anti-inflammatory and for the treatment of respiratory disease. Until now, these two properties had not been scientifically demonstrate…
  • Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms. [Journal Article]
    PLoS One. 2019; 14(1):e0211229.Strauch MA, Tomaz MA, … Melo PA
  • CONCLUSIONS: This research using a natural quinone and some related synthetic quinone compounds has shown that they exhibit antivenom activity; especially the compound 3a. The data from 3a showed a decrease in inflammatory venom effects, presumably those that are metalloproteinase-derived. Its ability to counteract such snake venom activities contributes to the search for improving the management of venomous snakebites.
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