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100 results
  • Spatial and temporal projections of the prevalence of active tuberculosis in Cambodia. [Journal Article]
    BMJ Glob Health 2019; 4(1):e001083Prem K, Pheng SH, … Cook AR
  • CONCLUSIONS: Synthesis of health and geographic data allows likely disease rates to be mapped at a high resolution to facilitate resource planning, while demographic modelling allows scenarios to be projected, demonstrating the need for the acceleration of control efforts to achieve a substantive impact on the future burden of TB in Cambodia.
  • Features of the clinical picture in patients of middle age with essential hypertension. [Journal Article]
    Ter Arkh 2018; 90(9):15-26Parfenov VA, Ostroumova ТМ, … Pavleyva EE
  • CONCLUSIONS: Complaints about memory dysfunction, lack of attention, sleep disturbances, less common - dizziness and headaches, are most typical in patients with EAH on the early stages of the disease. They differ from healthy volunteers of the same age by having cognitive impairment and higher anxiety and depression scores. Patients with EAH who complained about sleep disturbances had low sleep quality. Headache in patients with EAH was due to episodic migraine and tension type headache which had a negative impact on life and daily living.
  • Acquired Resilience: An Evolved System of Tissue Protection in Mammals. [Review]
    Dose Response 2018 Oct-Dec; 16(4):1559325818803428Stone J, Mitrofanis J, … Eells J
  • This review brings together observations on the stress-induced regulation of resilience mechanisms in body tissues. It is argued that the stresses that induce tissue resilience in mammals arise from everyday sources: sunlight, food, lack of food, hypoxia and physical stresses. At low levels, these stresses induce an organised protective response in probably all tissues; and, at some higher level,…
  • RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. [Journal Article]
    Proc Natl Acad Sci U S A 2018; 115(44):E10352-E10361Liu P, Rojo de la Vega M, … Zhang DD
  • NRF2 regulates cellular redox homeostasis, metabolic balance, and proteostasis by forming a dimer with small musculoaponeurotic fibrosarcoma proteins (sMAFs) and binding to antioxidant response elements (AREs) to activate target gene transcription. In contrast, NRF2-ARE-dependent transcriptional repression is unreported. Here, we describe NRF2-mediated gene repression via a specific seven-nucleot…
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