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4,637 results
  • Development of Pediatric Orodispersible Tablets Based on Efavirenz as a New Therapeutic Alternative. [Journal Article]
    Curr HIV Res. 2020 Jul 02 [Online ahead of print]de Freitas Neto JL, do Nascimento Gomes Barbosa I, … Neto PJR
  • CONCLUSIONS: It was observed that reduced concentrations of mannitol decrease the hardness and disintegration time of the formulations. The orodispersible tablet composed of efavirenz: β-cyclodextrin: polyvinylpyrrolidone, favors greater absorption and bioavailability. It has several advantages for pediatric patients, as the dosage form disintegrates quickly in the mouth and does not require water for administration, and which improves patient compliance with treatment.
  • Quantile-specific heritability of high-density lipoproteins with implications for precision medicine. [Journal Article]
    J Clin Lipidol. 2020 May 29 [Online ahead of print]Williams PT
  • CONCLUSIONS: HDL cholesterol heritability increased with increasing percentile of the offspring's HDL distribution. Whereas precision medicine is based on the premise that genetic markers identify patients most likely to benefit from drugs and diet, quantile-dependent expressivity postulates that the strong signals from these genetic markers simply trace the heritability increase with increasing plasma HDL concentrations. Thus, quantile-dependent expressivity provides an alternative interpretation to these genotype-specific effects.
  • Application of Molecular Docking for the Development of Improved HIV-1 Reverse Transcriptase Inhibitors. [Journal Article]
    Curr Comput Aided Drug Des. 2020 Jun 27 [Online ahead of print]Soltani A, Hashemy SI, … Mashkani B
  • Introoduction: Inhibition of the reverse transcriptase (RT) enzyme of human immunodeficiency virus (HIV) by low molecular weight inhibitors is still an active area of research. Here, protein-ligand interactions and possible binding modes of novel compounds with the HIV-1 RT binding pocket (the wild-type as well as Y181C and K103N mutants) were obtained and discussed. Methods: A molecular fragmen…
  • Bone turnover markers in children living with HIV remaining on ritonavir-boosted lopinavir or switching to efavirenz. [Journal Article]
    Bone. 2020 Jun 23 [Online ahead of print]Shiau S, Yin MT, … Arpadi SM
  • CONCLUSIONS: Overall, we failed to detect difference in bone turnover by P1NP and CTx in virologically-suppressed CLWH on different regimens at a time point close to the switch. We did observe higher levels of total osteocalcin in children remaining on LPV/r compared to children switched to efavirenz. Future studies should focus on uncovering the mechanism and determining whether perturbation in undercarboxylated osteocalcin could explain some of the bone side effects noted with protease inhibitors.
  • Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV. [Journal Article]
    Colloids Surf B Biointerfaces. 2020 Jun 06; 194:111174.Patki M, Vartak R, … Patel K
  • Preexposure prophylaxis (PrEP) using oral or vaginal microbicide is an emerging and effective strategy to prevent HIV transmission. Vaginal film is becoming more acceptable and a convenient dosage form compared to cream, gel and suppository. Extremely poor aqueous solubility of efavirenz (EFV) limits its use as vaginal microbicide. The aim of this study was to develop and evaluate a monomeric sur…
  • Changes in functional connectivity in people with HIV switching antiretroviral therapy. [Journal Article]
    J Neurovirol. 2020 Jun 04 [Online ahead of print]Toniolo S, Cercignani M, … Vera JH
  • We assessed changes in functional connectivity by fMRI (functional magnetic resonance imaging) and cognitive measures in otherwise neurologically asymptomatic people with HIV (PWH) switching combination antiretroviral therapy (cART). In a prospective study (baseline and follow-up after at least 4 months), virologically suppressed PWH switched non-nuclease reverse-transcriptase inhibitors (NNRTI; …
  • Retrospective analysis of HIV-1 drug resistance mutations in Suzhou, China from 2009 to 2014. [Journal Article]
    Virus Genes. 2020 Jun 04 [Online ahead of print]Song Y, Hu J, … Ya X
  • In this study, we investigated drug resistance levels in human immunodeficiency virus (HIV)-1-infected patients in Suzhou by retrospectively analyzing this property and the characteristics of circulating HIV-1 strains collected from 2009 to 2014. A total of 261 HIV-1-positive plasma samples, confirmed by the Suzhou CDC, were collected and evaluated to detect HIV-1 drug resistance genotypes using …
  • Cost-effectiveness analysis of pre-ART HIV drug resistance testing in Kenyan women. [Journal Article]
    EClinicalMedicine. 2020 May; 22:100355.Duarte HA, Babigumira JB, … Bendavid E
  • The prevalence of pre-treatment drug resistance (PDR) to non-nucleoside reverse-transcriptase inhibitor (NNRTI) agents is increasing in sub-Saharan Africa, which may decrease the effectiveness of efavirenz-based antiretroviral therapy (ART) programs. However, due to recent safety concerns, there has been hesitancy to replace efavirenz-based ART with dolutegravir in women of reproductive potential…
  • Suicidal ideation, psychopathology and associated factors among HIV-infected adults in Indonesia. [Journal Article]
    BMC Psychiatry. 2020 May 24; 20(1):255.Ophinni Y, Adrian , … Hayashi Y
  • CONCLUSIONS: Suicidal ideation is commonly found among Indonesian HIV-infected adults on ART. Depressive symptoms and efavirenz use are independent factors related to the presence of suicidal ideation. Thus, early screening of psychopathology as well as substitution of efavirenz with other ART regiment are recommended to prevent suicide and improve HIV/AIDS management outcome.
  • Perinatal exposure of rats to the HIV drug efavirenz affects medial prefrontal cortex cytoarchitecture. [Journal Article]
    Biochem Pharmacol. 2020 May 21 [Online ahead of print]Garcia LP, Van de Wijer L, … Kolk SM
  • Efavirenz (EFV) is used for antiretroviral treatment of HIV infection, and successfully inhibits viral replication and mother-to-child transmission of HIV during pregnancy and childbirth. Unfortunately, the drug induces neuropsychiatric symptoms such as anxiety and depressed mood and potentially affects cognitive performance. EFV acts on, among others, the serotonin transporter and serotonin rece…
  • Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging. [Journal Article]
    Analyst. 2020 May 18 [Online ahead of print]Gilliland WM, White NR, … Rosen EP
  • Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair may be compromised by any cosmetic hair treatments. Here, we investigate infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI response to multiple antiretrovirals (ARVs) in co…
  • Etonogestrel concentrations among contraceptive implant users in Botswana using and not using dolutegravir-based antiretroviral therapy. [Journal Article]
    Contraception. 2020 May 07 [Online ahead of print]Bishop IJ, Gertz AM, … Morroni C
  • CONCLUSIONS: Implant users receiving dolutegravir-based ART had a higher mean etonogestrel concentration compared to HIV-negative women, and none had etonogestrel concentrations below the posited threshold for ovulation suppression. In contrast, women in the efavirenz-group had much lower etonogestrel concentrations. Overall, these data provide evidence that the etonogestrel implant may be effectively combined with dolutegravir-based ART regimens.The etonogestrel implant remains a highly effective contraceptive option for women living with HIV who use dolutegravir-based ART.
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