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(effector cell)
81,233 results
  • RIPK1 mediates TNF-induced intestinal crypt apoptosis during chronic NF-κB activation. [Journal Article]
    Cell Mol Gastroenterol Hepatol 2019Wong J, Garcia-Carbonell R, … Guma M
  • CONCLUSIONS: Contrary to common expectations, chronic NF-κB activation induced intestinal crypt apoptosis after TNF stimulation, resulting in severe mucosal erosion. RIPK1 kinase inhibitors selectively inhibited TNF's destructive properties while preserving its survival and proliferative properties, which do not require RIPK1 kinase activity. RIPK1 kinase inhibition could be a potential treatment for IBD.
  • The potential and controversy of targeting STAT family members in cancer. [Review]
    Semin Cancer Biol 2019Verhoeven Y, Tilborghs S, … van Dam PA
  • The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of immune cells. To date, seven STAT genes have been identified in the human genom…
  • Targeting immunotherapy for bladder cancer by using anti-CD3 × CD155 bispecific antibody. [Journal Article]
    J Cancer 2019; 10(21):5153-5161Ma W, Ma J, … Zhang M
  • To investigate whether CD155 is an attractive target for T cell-mediated immunotherapy against human bladder cancer, we examined the novel bispecific antibody anti-CD3 x anti-CD155 (CD155Bi-Ab) for its ability to redirect activated T cells (ATCs) to target bladder cancer cells was examined. Expression of CD155 was detected by flow cytometry on the surface of bladder cancer cells, including T24 an…
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