- A New Planning Method to Easily Harvest the Superficial Circumflex Iliac Artery Perforator Flap. [Journal Article]J Reconstr Microsurg 2019JR
- CONCLUSIONS: Points D and S method for medial branch based SCIP planning with CTA is an easy to learn, efficient, fast, and reliable technique for preoperative planning, allowing a safe and predictable elevation of the flap.
- Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome. [Journal Article]Crit Care Med 2019CC
- CONCLUSIONS: Our results suggest that two distinct subphenotypes are present not only in patients with established acute respiratory distress syndrome but also in patients at risk for its development. Hyperinflammatory classification at baseline is associated with higher severity of illness, worse clinical outcomes, and trajectories of persistently elevated biomarkers of host injury and inflammation during acute critical illness compared with hypoinflammatory patients. Our findings provide strong rationale for examining treatment effect modifications by subphenotypes in randomized clinical trials to inform precision therapeutic approaches in critical care.
- Clinical and procedural characteristics of persons living with HIV presenting with acute coronary syndrome. [Journal Article]AIDS 2019AIDS
- CONCLUSIONS: PLWH hospitalized with ACS were more likely to have severe single-vessel disease, present with STEMI rather than NSTEMI, and undergo revascularization, and less likely to have a drug-eluting stent placed than matched HIV-negative controls, suggesting that coronary plaque morphology and/or distribution is different with HIV infection and warrants further investigation.
- Abstract 10613: Symptomatic Human Immunodeficiency Virus Infected Patients Receive Less Aggressive Revascularization Management After Acute Coronary Syndrome, a 5-year Nationwide Analysis. [Journal Article]Circulation 2019; 140(Suppl_1):A10613Circ
- CONCLUSIONS: Analysis shows a treatment disparity for ACS for symptomatic HIV patients only as symptomatic HIV affected patients received less aggressive catheterization and revascularization management after ACS, compared to control group. However, this effect was not present for the asymptomatic HIV patient group.
- Reteplase versus Streptokinase in Management of ST-segment Elevation Myocardial Infarction; a Letter to the Editor. [Journal Article]Adv J Emerg Med 2019; 3(4):e34AJ
- Interpreting Elevated TSH in Older Adults. [Journal Article]Curr Opin Endocr Metab Res 2019; 5:68-73CO
- Thyroid function is most often monitored clinically through measurement of the regulatory hormone, thyrotropin (TSH). Subclinical hypothyroidism is generally defined as a TSH level above the reference range while thyroid hormone levels remain within the reference range. Elevated TSH is more common among older adults, leading to high rates of treatment, and over-treatment, in this population. Howe…
Thyroid function is most often monitored clinically through measurement of the regulatory hormone, thyrotropin (TSH). Subclinical hypothyroidism is generally defined as a TSH level above the reference range while thyroid hormone levels remain within the reference range. Elevated TSH is more common among older adults, leading to high rates of treatment, and over-treatment, in this population. However, the use of levothyroxine in older adults with mild TSH elevations has begun to be called into question by observations that demonstrate a lack of harm from not treating and a lack of benefit from treating. Importantly, these findings suggest that the existing diagnostic algorithm for subclinical hypothyroidism, based on isolated TSH elevation, may be inappropriate for older adults. Age-specific reference ranges have been suggested as a way to avoid inappropriate treatment, but that strategy continues to rely on population norms rather than disease definitions to drive clinical decisions. Recent insight into age-related variability in the underlying pathophysiology that impacts on thyroid function tests demonstrates the need for new clinical tools to allow the targeted use of therapy where it will have benefit.
- Environmental filtering of body size and darker coloration in pollinator communities indicate thermal restrictions on bees, but not flies, at high elevations. [Journal Article]PeerJ 2019; 7:e7867P
- CONCLUSIONS: The increase in filter intensity at high elevations exhibited by bees suggests a significant limitation on the breadth of viable functional strategies for coping with extreme cold, at least within this regional species pool. Flies, on the other hand, do not appear to be limited by high elevations, indicating that the shift from bee to fly dominance at high elevations may be due, at least in part, to greater environmental constraints on bee adaptation to colder environments.
- Current practice trends of oedema management in the hands of people with tetraplegia in Australia. [Journal Article]Spinal Cord Ser Cases 2019; 5:71SC
- CONCLUSIONS: Assessment and treatment practices were not consistent. Oedema in the hands in people with tetraplegia was perceived to have various impacts on a person's rehabilitation and hand function. The findings highlight the need for research evidence to guide practice.
- Efficacy of water spray for evaporative cooling in athletes with spinal cord injury. [Journal Article]Spinal Cord Ser Cases 2019; 5:51SC
- CONCLUSIONS: WS effectively attenuated Tc elevation during exercise in athletes with TP.
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- Working Smarter Not Harder: Oxytocin Increases Domestic Dogs' (Canis familiaris) Accuracy, but Not Attempts, on an Object Choice Task. [Journal Article]Front Psychol 2019; 10:2141FP
- The neuropeptide oxytocin (OT) has been shown to enhance dogs' ability to perform an object choice task (OCT) involving the use of human pointing cues, when delivered intranasally. This study aimed at further investigating whether OT enhances task performance by increasing choices made, or by increasing correctness of choices made, and to compare these treatment effects to dog appeasing pheromone…
The neuropeptide oxytocin (OT) has been shown to enhance dogs' ability to perform an object choice task (OCT) involving the use of human pointing cues, when delivered intranasally. This study aimed at further investigating whether OT enhances task performance by increasing choices made, or by increasing correctness of choices made, and to compare these treatment effects to dog appeasing pheromone (DAP), known to balance emotional activation in dogs. Hence, we compared OCT performance between three groups of dogs: (i) dogs administered OT and a sham collar, (ii) dogs administered a saline placebo and a DAP collar, and (iii) control dogs administered a saline placebo and a sham collar. All three groups consisted of a combination of male and female pet dogs and assistance-dogs-in-training currently living with a volunteer carer. The study also evaluated the effect of intranasal OT and/or DAP on plasma levels of OT, and prolactin; which has previously been linked with anxiety in dogs. The dogs' emotional state was measured using the Emotional Disorders Evaluation in Dogs (EDED) scale. The owners'/carers' degree of anxious- and avoidant-style attachment to their dogs was accessed using the Pet Attachment Questionnaire (PAQ). Interesting descriptive data appeared for both treatment groups. Particularly, in OT group, we obtained significant results demonstrating that intranasal OT enhances OCT performance in dogs compared to control, by increasing the percentage of correct choices, but not the number of choices, made. Results also support that the mode of action of intranasal OT is via direct access to the brain and not via the blood, since no elevation of plasma OT (or prolactin) levels were observed after intranasal administration in this study. Similarly, DAP application did not significantly alter OT or prolactin peripheral concentrations. Several differences were observed between fostered and pet dogs, namely: fostered dogs demonstrated higher levels of serum prolactin, made more choices on the OCT compared to pet dogs but were not more likely to be correct, and were fostered by carers with higher avoidant attachment scores than pet dog owners. These findings implicate consideration of potential carer and training consequences for assistance dogs.