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162,020 results
  • Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome. [Journal Article]
    Crit Care Med 2019Kitsios GD, Yang L, … McVerry BJ
  • CONCLUSIONS: Our results suggest that two distinct subphenotypes are present not only in patients with established acute respiratory distress syndrome but also in patients at risk for its development. Hyperinflammatory classification at baseline is associated with higher severity of illness, worse clinical outcomes, and trajectories of persistently elevated biomarkers of host injury and inflammation during acute critical illness compared with hypoinflammatory patients. Our findings provide strong rationale for examining treatment effect modifications by subphenotypes in randomized clinical trials to inform precision therapeutic approaches in critical care.
  • Interpreting Elevated TSH in Older Adults. [Journal Article]
    Curr Opin Endocr Metab Res 2019; 5:68-73Mammen JS
  • Thyroid function is most often monitored clinically through measurement of the regulatory hormone, thyrotropin (TSH). Subclinical hypothyroidism is generally defined as a TSH level above the reference range while thyroid hormone levels remain within the reference range. Elevated TSH is more common among older adults, leading to high rates of treatment, and over-treatment, in this population. Howe…
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