- Improved diagnosis of retinal laser injuries using near-infrared autofluorescence. [Journal Article]
- AJAm J Ophthalmol 2019 Jun 11
- CONCLUSIONS: An increased incidence of retinal injuries secondary to handheld lasers has been reported in recent years. We show that the diagnosis and full extent of retinal laser injuries is best demonstrated by NIR-AF, as other modalities give variable results. We propose that NIR-AF should be included when investigating patients suspected of macular injury secondary to exposure to handheld lasers.
- Microvascular change in acute macular neuroretinopathy by using optical coherence tomography angiography. [Case Reports]
- TJTaiwan J Ophthalmol 2019 Apr-Jun; 9(2):118-121
- A 27-year-old pregnant female underwent cesarean section due to preeclampsia. Two days after the delivery, she presented with acute onset of blurred vision in the left eye. Optical coherence tomograp…
A 27-year-old pregnant female underwent cesarean section due to preeclampsia. Two days after the delivery, she presented with acute onset of blurred vision in the left eye. Optical coherence tomography (OCT) revealed characteristic findings of acute macular neuroretinopathy (AMN) in both eyes. During the follow-up, her vision improved gradually, but outer nuclear layer thinning with disruption of ellipsoid zone was identified from OCT. OCT angiography was arranged and revealed both vascular defect in superficial and deep vascular plexus, which correlated with previous AMN lesions in both eyes. Subsequent microvascular change in AMN was found to involve both superficial and deep vascular plexus, which is different from the current consensus that AMN mainly involved deep vascular plexus. By using the OCT angiography, we can better visualize the detail retinal vascular structure and may identify the real mechanism in this rare retinal disorder.
- Evaluation of tumor shape features for overall survival prognosis in glioblastoma multiforme patients. [Journal Article]
- SOSurg Oncol 2019; 29:178-183
- Glioblastoma multiforme (GBM) is a rapidly growing tumor associated with poor prognosis. This study evaluates the effectiveness of thirteen tumor shape features for overall survival (OS) prognosis in…
Glioblastoma multiforme (GBM) is a rapidly growing tumor associated with poor prognosis. This study evaluates the effectiveness of thirteen tumor shape features for overall survival (OS) prognosis in GBM patients. Shape features were extracted from the abnormality regions of the GBM tumor visible on the fluid attenuated inversion recovery (FLAIR) and T1-weighted contrast enhanced (T1CE) MR images of GBM patients. Survival analysis was performed using univariate and multivariate (with clinical features) Cox proportional hazards regression analysis. Kaplan-Meier survival curves were plotted and observed for the shape features which were found to be significant from the Cox regression analysis. Three 3D shape features: Bounding ellipsoid volume ratio (BEVR), sphericity and spherical disproportion, computed from both the abnormality regions were found to be significant for OS prognosis in GBM patients.
- Utility of en-face imaging in diagnosis of occult macular dystrophy with RP1L1 mutation: A case series. [Case Reports]
- AJAm J Ophthalmol Case Rep 2019; 15:100465
- CONCLUSIONS: This is a report of two patients with EZ en-face imaging that aided in the diagnosis of OMD where other structural imaging was largely unremarkable. The en-face imaging modality can also be used to monitor OMD progression.
- Entry modes of ellipsoidal nanoparticles on a membrane during clathrin-mediated endocytosis. [Journal Article]
- SMSoft Matter 2019 Jun 13
- The membrane wrapping and internalization of nanoparticles, such as viruses and drug nanocarriers, through clathrin-mediated endocytosis (CME) are vitally important for intracellular transport. Durin…
The membrane wrapping and internalization of nanoparticles, such as viruses and drug nanocarriers, through clathrin-mediated endocytosis (CME) are vitally important for intracellular transport. During CME, the shape of the particle plays crucial roles in the determination of particle-membrane interactions, but much of the previous work has been focused on spherical particles. In this work, we develop a stochastic model to study the CME of ellipsoidal particles. In our model, the deformation of the membrane and wrapping of the nanoparticles are driven by the accumulation of clathrin lattices, which is stimulated by the ligand-receptor interactions. Using our model, we systematically investigate the effect of particle shape (ellipsoids with different aspect ratios) on the CME. Our results show three entry modes: tip-first, tilted, and laying-down modes, used by ellipsoidal nanoparticles for internalization depending on the aspect ratio. Certain ellipsoids are able to take multiple entry modes for internalization. Interestingly, the prolate ellipsoid with an aspect ratio of 0.42 can be internalized with a significantly reduced number of ligand-receptor bonds. Particles which can be internalized with fewer bonds are excellent candidates for transcellular drug delivery. Moreover, our results demonstrate that internalization of ellipsoids with intermediate aspect ratios is easier than that of particles with low and high aspect ratios. Our model and simulations provide critical mechanistic insights into CME of ellipsoidal particles, and represent a viable platform for optimal design of nanoparticles for targeted drug delivery applications.
- Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers. [Journal Article]
- DSDrug Saf 2019 Jun 11
- CONCLUSIONS: There was no evidence of any pharmacodynamic effect of 300-mg single-dose tafenoquine on the retina or any short-term clinically relevant effects on ophthalmic safety. This clinical trial is registered with ClinicalTrials.gov (identifier: NCT02658435).
- Disorganization of retinal inner layers correlates with ellipsoid zone disruption and retinal nerve fiber layer thinning in diabetic retinopathy. [Journal Article]
- JDJ Diabetes Complications 2019 May 17
- CONCLUSIONS: Presence of DRIL correlates with severity of DR, EZ disruption and RNFL thinning.
- A viscoelastic ellipsoidal model of the mechanics of plantar tissues. [Journal Article]
- JBJ Biomech 2019 May 30
- Several assessments of the mechanics of plantar tissues, using various material models in conjunction with representing plantar regions using simple geometry, have been proposed. In this study, the p…
Several assessments of the mechanics of plantar tissues, using various material models in conjunction with representing plantar regions using simple geometry, have been proposed. In this study, the plantar tissues were divided into eight regions to account for the various tissue characteristics. The plantar tissue model described each region as an ellipsoid, with a viscoelastic material model. The model combined varying elliptical contact areas with nonlinear tissue stiffness and damping. The main instruments used in this research were pressure-measuring insoles, which were used to determine the ground reaction force, as well as contact areas. The measured contact areas were fitted as elliptical areas to describe the compression of the corresponding ellipsoids. The approach was tested using walking data collected from 26 individuals: four men, 22 women, 24.4 ± 6.9 years old, 66.9 ± 21.4 kg of mass, 1.66 ± 0.12 m tall. The geometric and material variables of the proposed ellipsoidal model were optimized for each participant to match the ground reaction forces. Results suggest that the ellipsoid model is able to reproduce ground reaction force with reasonable accuracy. The largest errors were seen in heel and toe regions and were due to high-rate forces and small comparative areas, respectively. The model also showed that there are regional differences in the mechanical characteristics of plantar tissue, which confirms earlier research.
- Páramo Calamagrostis s.l. (Poaceae): An updated list and key to the species known or likely to occur in páramos of NW South America and southern Central America including two new species, one new variety and five new records for Colombia. [Journal Article]
- PPhytoKeys 2019; 122:29-78
- Calamagrostis (syn. Deyeuxia), as traditionally circumscribed, is one of the most speciose genera from páramo grasslands of northwest South America and southern Central America and often dominates th…
Calamagrostis (syn. Deyeuxia), as traditionally circumscribed, is one of the most speciose genera from páramo grasslands of northwest South America and southern Central America and often dominates these high-elevation habitats. However, it remains difficult for researchers to accurately identify the species due to a lack of floristic treatments for most of the countries containing páramo, with the distribution of many species still very poorly known. In an effort to ameliorate this, we present an updated list and identification keys in English and Spanish (as electronic appendix) to the species of Calamagrostis s.l. known or likely to occur in the páramos of Peru, Ecuador, Colombia, Venezuela, Costa Rica and Panama. Fifty-four species are accepted, constituting 47 species currently circumscribed in Calamagrostis and seven species recently transferred to Deschampsia. Included within this are two new species, Calamagrostiscrispifolius and Deschampsiasantamartensis, which are described and illustrated. Both new species are found in páramos of the Sierra Nevada de Santa Marta (departamento Magdalena), on the northernmost tip of Colombia, with C.crispifolius also found in the Serrania de Perija on the border with Venezuela. Calamagrostiscrispifolius differs from all other species of Calamagrostis s.l. by the presence of strongly curled, readily deciduous leaf blades, amongst numerous other characteristics including open inflorescences with generally patent branches, small spikelets, (3.5-)4-5.5 mm long, with sessile florets and a rachilla prolongation reaching from 2/3 to almost the apex of the lemma, with short hairs (< 1 mm long). Deschampsiasantamartensis is similar to Deschampsiahackelii (=Calamagrostishackelii) from austral South America but differs by its broad, rigid and erect, strongly conduplicate blades, 1.5-2.5 mm wide when folded, ligules of innovations 0.5-1 mm long, truncate or obtuse, ligules of upper flowering culms 3-4 mm long, broadly shouldered with an attenuate central point, ellipsoid spike-like panicle, 3-5.5 long × 1.5-2.5 cm wide, lemma surfaces moderately to lightly scabrous between the veins, lemma apex acute to muticous, entire, rachilla extension often absent and inside of the floret often with hyaline shiny sinuous trichomes to 1 mm long, emerging from the base of the ovary. We also present a broader circumscription of the common species Deschampsiapodophora (=Calamagrostispodophora), with the new variety D.podophoravar.mutica described and illustrated. Deschampsiapodophoravar.mutica principally differs from var. podophora by florets lacking awns and larger habit i.e. multiple taller culms with longer and wider leaf blades forming tussocks, with inflorescences often held within sheaths. Nomenclatural changes are presented, with Deyeuxiamacrostachya newly synonymised under C.macrophylla and C.pittieri, C.pubescens and Deyeuxiapubescens newly synonimised under C.planifolia. Lectotypes are designated for Agrostisantoniana, Calamagrostispisinna, Deyeuxiamacrostachya and Deyeuxiasodiroana. We also document and give notes on five new records of Calamagrostis for Colombia: C.carchiensis, C.guamanensis, C.heterophylla, C.pisinna and C.rigida.
New Search Next
- Shape-designable liquid marbles stabilized by gel layer. [Journal Article]
- LLangmuir 2019 Jun 09
- Shape-designable liquid marbles were simply prepared by rolling the water droplets over the stearic acid powder for several seconds to encapsulate them. The effects of droplet volume, pH and rolling …
Shape-designable liquid marbles were simply prepared by rolling the water droplets over the stearic acid powder for several seconds to encapsulate them. The effects of droplet volume, pH and rolling time on the deformability of liquid marbles from sphere were investigated. The stearic acid-stabilized liquid marbles can be deformed to any desirable and stable shapes including ellipsoid and letters, thanks to the gel layer formed at liquid marble surfaces during the preparation. The gel layer works as a flexible and plastic membrane, which makes the liquid marbles irreversibly deformable. Finally, the applications of the liquid marbles as a microreactor were demonstrated.