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(emetic syndrome)
540 results
  • A concise historical perspective of the area postrema structure and function. [Journal Article]
    Arq Neuropsiquiatr 2020DE Souza TFS
  • First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was a…
  • Pathophysiology of Vomiting and Esophageal Perforation in Boerhaave's Syndrome. [Journal Article]
    Dig Dis Sci 2020Kuwano H, Yokobori T, … Shirabe K
  • CONCLUSIONS: We hypothesize that vomiting occurred by retrograde propagation of gastrointestinal motor contraction from the jejunum to the gastric antrum, followed by prolapse of the gastric fornix mucosal into the esophagus. Subsequent esophageal perforation probably resulted from excessive prolapse due to strong contraction and destruction of the muscularis mucosa of the left side of abdominal esophagus, with longitudinal stretching of the whole left esophageal wall due to traction. We also propose that Boerhaave's syndrome is defined as "post-emetic esophageal perforation" to ensure broader recognition and more expedient diagnosis and treatment. Remaining conditions without any definite causes may be labeled "idiopathic" or "spontaneous" rupture of the esophagus.
  • Population structure and toxin gene profiles of Bacillus cereus sensu lato isolated from flour products. [Journal Article]
    FEMS Microbiol Lett 2019; 366(20)Kindle P, Etter D, … Johler S
  • Data on the occurrence, population structure and toxinogenic potential of Bacillus cereus sensu lato isolated from flour is essential to enable improved risk assessment. We aimed to provide data on the occurrence of B. cereus sensu lato in flour products at retail level. In addition, we screened the isolates for Bacillus thuringiensis and Bacillus cytotoxicus and determined population structure a…
  • Emerging Role of Aprepitant in Cannabis Hyperemesis Syndrome. [Case Reports]
    Cureus 2019; 11(6):e4825Parvataneni S, Varela L, … Maneval ML
  • Cannabis hyperemesis syndrome (CHS) is a clinical syndrome associated with prolonged and regular cannabis use. CHS is characterized by recurrent episodes of intractable nausea and vomiting. Given the overlap with other medical conditions and the frequent delay in diagnosis, finding an effective anti-emetic regimen for symptomatic control of CHS can be challenging. We report a case study where apr…
  • Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. [Journal Article]
    Nat Commun 2019; 10(1):3225Basak S, Gicheru Y, … Chakrapani S
  • Serotonin receptor (5-HT3AR) is the most common therapeutic target to manage the nausea and vomiting during cancer therapies and in the treatment of irritable bowel syndrome. Setrons, a class of competitive antagonists, cause functional inhibition of 5-HT3AR in the gastrointestinal tract and brainstem, acting as effective anti-emetic agents. Despite their prevalent use, the molecular mechanisms u…
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