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(emetic syndrome)
531 results
  • Emerging Role of Aprepitant in Cannabis Hyperemesis Syndrome. [Case Reports]
    Cureus 2019; 11(6):e4825Parvataneni S, Varela L, … Maneval ML
  • Cannabis hyperemesis syndrome (CHS) is a clinical syndrome associated with prolonged and regular cannabis use. CHS is characterized by recurrent episodes of intractable nausea and vomiting. Given the overlap with other medical conditions and the frequent delay in diagnosis, finding an effective anti-emetic regimen for symptomatic control of CHS can be challenging. We report a case study where apr…
  • Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. [Journal Article]
    Nat Commun 2019; 10(1):3225Basak S, Gicheru Y, … Chakrapani S
  • Serotonin receptor (5-HT3AR) is the most common therapeutic target to manage the nausea and vomiting during cancer therapies and in the treatment of irritable bowel syndrome. Setrons, a class of competitive antagonists, cause functional inhibition of 5-HT3AR in the gastrointestinal tract and brainstem, acting as effective anti-emetic agents. Despite their prevalent use, the molecular mechanisms u…
  • A Practical Management Approach to Gastroparesis. [Review]
    Intern Med J 2019Longley K, Ho V
  • Gastroparesis is a syndrome characterised by delayed gastric emptying in the absence of mechanical obstruction. Symptoms can include early satiety, abdominal pain, bloating, vomiting, and regurgitation which cause significant morbidity in addition to nutritional deficits. There is a higher prevalence in diabetics and females, but the incidence in the Australian population has not been well studie…
  • A commentary on the medicinal use of marijuana. [Review]
    Trop Med Health 2019; 47:35Tawfik GM, Hashan MR, … Huy NT
  • CONCLUSIONS: Many countries started to allow medicinal use of marijuana due to its beneficial effect in managing chronic pain, spasticity symptoms in multiple sclerosis, obstructive sleep apnea syndrome, fibromyalgia, and posttraumatic stress disorder. But literature lacks benefit-harm analysis for marijuana usage in medicine. Therefore, evidence-based report of short- and long-term health effects of marijuana use-both harmful and beneficial effects-is crucial for further marijuana prescription in healthcare settings.
  • Food Protein-Induced Enterocolitis Syndrome: a Comprehensive Review. [Review]
    Clin Rev Allergy Immunol 2019Agyemang A, Nowak-Wegrzyn A
  • Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that has been well-characterized clinically, yet it is still poorly understood. Acute FPIES is characterized by vomiting 1-4 h and/or diarrhea within 24 h after ingestion of a culprit food. Chronic FPIES is the result of chronic exposure to an offending food that can result in chronic watery diarrhea, intermitt…
  • StatPearls: Cannaboinoid Antiemetic Therapy [BOOK]
    StatPearls Publishing: Treasure Island (FL) Taylor Bryce N. BN Lincoln Memorial Un - DeBusk College OM Sauls Ryan S. RS Lincoln Memorial Un- DeBusk College OM BOOK
  • There are currently three cannabinoids available on the pharmaceutical market.  Dronabinol and Nabilone are both synthetic tetrahydrocannabinol (THC) which the FDA has approved for treatment of chemotherapy-induced nausea and vomiting (CINV) after the failure of a trial of first-line anti-emetics.  Both are also FDA approved to treat anorexia associated with AIDS.  Recently, the FDA has also appr…
  • Antibiotics and chemical disease-control agents reduce innate disease resistance in crayfish. [Journal Article]
    Fish Shellfish Immunol 2019; 86:169-178Ma X, Zhu F, Jin Q
  • The aquaculture industry has developed rapidly in recent years, and in China Crayfish Procambarus clarkii represent an important aquaculture fishery. However, bacterial and viral diseases are becoming an increasingly serious threat, causing considerable economic losses. Farmers use a large number of drugs and chemicals to destroy pathogenic microorganisms and to purify aquaculture water. The purp…
  • Conformational transitions of the serotonin 5-HT3 receptor. [Journal Article]
    Nature 2018; 563(7730):275-279Polovinkin L, Hassaine G, … Nury H
  • The serotonin 5-HT3 receptor is a pentameric ligand-gated ion channel (pLGIC). It belongs to a large family of receptors that function as allosteric signal transducers across the plasma membrane1,2; upon binding of neurotransmitter molecules to extracellular sites, the receptors undergo complex conformational transitions that result in transient opening of a pore permeable to ions. 5-HT3 receptor…
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