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29,470 results
  • Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance. [Review]
    Semin Immunol 2019; 42:101302Tang R, Rangachari M, Kuchroo VK
  • T cell inhibitory co-receptors play a crucial role in maintaining the balance between physiologic immune responses and maladaptive ones. T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a unique inhibitory co-receptor in that its expression is chiefly restricted to interferon (IFN)γ-producing CD4+ and CD8+ T cells. Early reports firmly established its importance in maintaining perip…
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