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Unbound Medicine.
(endocrine system)
473,531 results
  • Stress and the vestibular system. [Journal Article]
    Int Rev Neurobiol. 2020; 152:221-236.Saman Y, Arshad Q, … Rea P
  • In this chapter we review the existing literature regarding the interactions between stress and the mechanisms that maintain balance. Evidence suggests that the interplay between neuro-endocrine and psychological factors may have a significant role in balance function. For example, in healthy individuals vestibular stimulation has been shown to trigger the stress response as indicated by increase…
  • Metabolism and growth adaptation to environmental conditions in Drosophila. [Review]
    Cell Mol Life Sci. 2020 May 24 [Online ahead of print]Koyama T, Texada MJ, … Rewitz K
  • Organisms adapt to changing environments by adjusting their development, metabolism, and behavior to improve their chances of survival and reproduction. To achieve such flexibility, organisms must be able to sense and respond to changes in external environmental conditions and their internal state. Metabolic adaptation in response to altered nutrient availability is key to maintaining energy home…
  • Endocrine surgery during and after the COVID-19 epidemic: Expert guidelines from AFCE. [Journal Article]
    J Visc Surg. 2020 Apr 30 [Online ahead of print]Baud G, Brunaud L, … AFCE COVID Study Group
  • The COVID-19 pandemic commands a major reorganisation of the entire French healthcare system. In France, general rules have been issued nationally and implemented by each healthcare centre, both public and private, throughout France. Guidelines drafted by an expert group led by the French-speaking Association of Endocrine Surgery (AFCE) propose specific surgical management principles for thyroid,…
  • The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system. [Journal Article]
    Cytokine Growth Factor Rev. 2020 May 11 [Online ahead of print]Coperchini F, Chiovato L, … Rotondi M
  • In 2019-2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestati…
  • Metals, autoimmunity, and neuroendocrinology: Is there a connection? [Review]
    Environ Res. 2020 Apr 21; 187:109541.Bjørklund G, Dadar M, … Peana M
  • It has been demonstrated that metals can induce autoimmunity. However, few studies have attempted to assess and elucidate the underlying mechanisms of action. Recent research has tried to evaluate the possible interactions of the immune system with metal ions, particularly with heavy metals. Research indicates that metals have the potential to induce or promote the development of autoimmunity in …
  • Cardiac natriuretic peptides. [Review]
    Nat Rev Cardiol. 2020 May 22 [Online ahead of print]Goetze JP, Bruneau BG, … de Bold AJ
  • Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial appendages of the heart led to the discovery that these cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referred to as atrial natriuretic factor or atrial natriuretic peptide (ANP) and brain or B-type natriuretic peptide (BNP), thereby demonstrating an endocrine f…
  • IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer. [Review]
    Cells. 2020 May 20; 9(5)Cai Q, Dozmorov M, Oh Y
  • Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are IGFBP-1 through 6, IGFBP-3 is the most extensively investigated IGFBP species with respect to its IGF/IGF-I receptor (IGF-IR)-independent biological actions beyond its endocrine/paracrine/autocrine role in modulat…
  • Effect of the plastic pollutant bisphenol A on the biology of aquatic organisms: A meta-analysis. [Journal Article]
    Glob Chang Biol. 2020 May 21 [Online ahead of print]Wu NC, Seebacher F
  • Plastic pollution is a global environmental concern. In particular, the endocrine-disrupting chemical bisphenol A (BPA) is nearly ubiquitous in aquatic environments globally, and it continues to be produced and released into the environment in large quantities. BPA disrupts hormone signalling and can thereby have far-reaching physiological and ecological consequences. However, it is not clear whe…
  • Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor. [Journal Article]
    Neurobiol Stress. 2020 May; 12:100207.Belelli D, Hogenkamp D, … Lambert JJ
  • In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that such steroids may be synthesised not only in peripheral endocrine glands, but locally in the central nervous system (CNS), to potentially act as par…
  • Defining the characteristics of intermediate care models including transitional care: an international Delphi study. [Journal Article]
    Aging Clin Exp Res. 2020 May 19 [Online ahead of print]Sezgin D, O'Caoimh R, … European Union Advantage Joint Action Work Package 7 partners in collaboration with the International Foundation for Integrated Care Special Interest Group on Intermediate Care
  • CONCLUSIONS: There was agreement that intermediate care represents time-limited services which ensure continuity and quality of care, promote recovery, restore independence and confidence at the interface between home and acute services, with transitional care representing a subset of intermediate care. Models are best delivered by an interdisciplinary team within an integrated health and social care system where a single contact point optimises service access, communication and coordination.This study identified key defining features of intermediate care to improve understanding and to support comparisons between models and studies evaluating them. More research is required to develop operational definitions for use in different healthcare systems.
  • The Neuropeptide System and Colorectal Cancer Liver Metastases: Mechanisms and Management. [Review]
    Int J Mol Sci. 2020 May 15; 21(10)Kasprzak A, Adamek A
  • Colorectal cancer (CRC), classified as the third most prevalent cancer worldwide, remains to be a clinical and research challenge. It is estimated that ~50% of CRC patients die from distant metastases, with treatment of this complication still posing significant difficulties. While liver metastasis (LM) cascade is known in the literature, its mechanisms are still unclear and remain studied in dif…
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