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(endosome)
21,047 results
  • Niemann-Pick type C disease: cellular pathology and pharmacotherapy. [Review]
    J Neurochem 2019Wheeler S, Sillence DJ
  • Niemann-Pick type C disease (NPCD) was first described in 1914 and affects approximately 1 in 150,000 live births. It is characterisedPart of the graphics were re-drawn by Marco Bazelmans in a full version of BioRender (https://biorender.com/) on the basis of the author-provided graphics. clinically by diverse symptoms affecting liver, spleen, motor control and brain; premature death invariably r…
  • ToolBox: Live-Imaging of intracellular organelle transport in iPSC-derived neurons. [Journal Article]
    Traffic 2019Boecker CA, Olenick MA, … Holzbaur ELF
  • Induced pluripotent stem cells (iPSCs) hold promise to revolutionize studies of intracellular transport in live human neurons and to shed new light on the role of dysfunctional transport in neurodegenerative disorders. Here, we describe an approach for live-imaging axonal and dendritic transport in iPSC-derived cortical neurons. We use transfection and transient expression of genetically-encoded …
  • Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey. [Review]
    Cells 2019; 8(10)Crudden C, Song D, … Girnita L
  • Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles. These vesicles travel through the acidic endosome whereby receptors and ligands are sorted to be either recycled or degraded. The traditional paradigm postulated that the endocy…
  • NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells. [Journal Article]
    Clin Exp Metastasis 2019Kurata T, Rajendran V, … Fushida S
  • Na+/H+ exchanger 5 (NHE5) is enriched in neurons and cycles between recycling endosomes and plasma membranes and transports protons to the endosomal lumen as well as to the extracellular space. Although NHE5 expression is undetectable in normal astrocytes, C6 glioma cells express NHE5 at an elevated level. Using C6 cells as a model, here we demonstrate that NHE5 has an important role in tumor gro…
  • Endosomal signalling via exosome surface TGFβ-1. [Journal Article]
    J Extracell Vesicles 2019; 8(1):1650458Shelke GV, Yin Y, … Lötvall J
  • Extracellular vesicles such as exosomes convey biological messages between cells, either by surface-to-surface interaction or by shuttling of bioactive molecules to a recipient cell's cytoplasm. Here we show that exosomes released by mast cells harbour both active and latent transforming growth factor β-1 (TGFβ-1) on their surfaces. The latent form of TGFβ-1 is associated with the exosomes via he…
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