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175 results
  • Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium. [Journal Article]
    J Exp Med 2019; 216(8):1874-1890Ricard N, Scott RP, … Simons M
  • To define the role of ERK1/2 signaling in the quiescent endothelium, we induced endothelial Erk2 knockout in adult Erk1-/- mice. This resulted in a rapid onset of hypertension, a decrease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5 wk. Immunostaining and endothelial fate mapping showed a robust increase in TGFβ signaling leading to widespread en…
  • Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries. [Journal Article]
    Am J Obstet Gynecol 2019; 221(3):219-226Brosens I, Brosens JJ, … Benagiano G
  • We explore the potential role of the endothelial lining of uteroplacental arteries in the pathogenesis of preeclampsia, a severe pregnancy disorder characterized by incomplete invasion of the uterine vasculature by extravillous trophoblast and angiogenic imbalance. In normal pregnancy, the endothelium disappears progressively from the uteroplacental arteries and is replaced by trophoblast and dep…
  • Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. [Review]
    Front Physiol 2018; 9:1470Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sanchez JC
  • The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of hep…
  • Preeclampsia: A close look at renal dysfunction. [Review]
    Biomed Pharmacother 2019; 109:408-416Moghaddas Sani H, Zununi Vahed S, Ardalan M
  • Preeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic factors originated from hypoxic placenta. It is simply defined by the new onset of hypertension (≥140/90 mmHg) and proteinuria (≥0.3 g/day) after 20 weeks of gestation. PE is associated with kidney dysfunction due to …
  • Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia. [Journal Article]
    Microcirculation 2018; :e12508Yu W, Gao W, … Khalil RA
  • Preeclampsia is a pregnancy-related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia, and reduced uterine perfusion pressure (RUPP). RUPP causes imbalance between the anti-angiogenic f…
  • Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. [Journal Article]
    JCI Insight 2018; 3(19)Sandgren JA, Deng G, … Grobe JL
  • Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is sufficient to induce the major phenotypes of PE in mice. Thus, we hypothesized a role for AVP in the pathogenesis of PE. AVP infusion into pregnant C57BL/6J mice resulted in hypertension, renal glomerular endotheliosis, int…
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