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30 results
  • Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma. [Journal Article]
    Mod Pathol. 2020 Apr 29 [Online ahead of print]Hayashi A, Yavas A, … Iacobuzio-Donahue CA
  • Entosis is a type of regulated cell death that promotes cancer cell competition. Though several studies have revealed the molecular mechanisms that govern entosis, the clinical and genetic correlates of entosis in human tumors is less well understood. Here we reviewed entotic cell-in-cell (CIC) patterns in a large single institution sequencing cohort (MSK IMPACT clinical sequencing cohort) of mor…
  • Condemned or Not to Die? Gene Polymorphisms Associated With Cell Death in Pemphigus Foliaceus. [Journal Article]
    Front Immunol. 2019; 10:2416.Bumiller-Bini V, Cipolla GA, … Boldt ABW
  • Pemphigus foliaceus (PF) is an autoimmune blistering skin disease that occurs sporadically across the globe and is endemic in Brazil. Keratinocyte adhesion loss (acantholysis) is associated with high levels of anti-desmoglein 1 IgG autoantibodies, but the role of cell death is poorly understood in PF. Current evidence disqualifies apoptosis as the major cell death mechanism and no other process h…
  • The molecular machinery of regulated cell death. [Review]
    Cell Res. 2019 05; 29(5):347-364.Tang D, Kang R, … Kroemer G
  • Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the …
  • Entosis Controls a Developmental Cell Clearance in C. elegans. [Journal Article]
    Cell Rep. 2019 03 19; 26(12):3212-3220.e4.Lee Y, Hamann JC, … Overholtzer M
  • Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to clear the male-specific linker cell in C. elegans. The linker cell leads migration to shape the gonad and is removed to facilitate fus…
  • Methods for the Study of Entotic Cell Death. [Journal Article]
    Methods Mol Biol. 2019; 1880:447-454.Hamann JC, Kim SE, Overholtzer M
  • Entosis is a mechanism of cell competition occurring in cancers that involves the engulfment and killing of neighboring cells. The death of ingested cells, called entotic cell death, usually occurs in a non-apoptotic, autophagy protein-dependent manner, where microtubule-associated protein light chain 3 (LC3) is lipidated onto entotic vacuoles. Here we present methods to quantify entotic cell dea…
  • Genomic instability in mutant p53 cancer cells upon entotic engulfment. [Journal Article]
    Nat Commun. 2018 08 03; 9(1):3070.Mackay HL, Moore D, … Muller PAJ
  • Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed cells physically interfere in cell divisions of host cells and for cells without p53 this leads to host cell death. In contrast, mutant p53 host cel…
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. [Review]
    Cell Death Differ. 2018 03; 25(3):486-541.Galluzzi L, Vitale I, … Kroemer G
  • Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing …
  • Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction. [Journal Article]
    Biochem Biophys Res Commun. 2018 01 01; 495(1):1440-1446.Ruan B, Zhang B, … Sun Q
  • Cell-in-cell structure is prevalent in human cancer, and associated with several specific pathophysiological phenomena. Although cell membrane adhesion molecules were found critical for cell-in-cell formation, the roles of other membrane components, such as lipids, remain to be explored. In this study, we attempted to investigate the effects of cholesterol and phospholipids on the formation of ce…
  • Consecutive entosis stages in human substrate-dependent cultured cells. [Journal Article]
    Sci Rep. 2017 10 02; 7(1):12555.Garanina AS, Kisurina-Evgenieva OP, … Onishchenko GE
  • Entosis, or cell death by invading another cell, is typical for tumor epithelial cells. The formation of cell-in-cell structures is extensively studied in suspension cultures, but remains poorly understood in substrate-dependent cells. Here, we used electron, confocal and time-lapse microscopy in combination with pharmacological inhibition of intracellular components to study the kinetics of ento…
  • MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. [Journal Article]
    J Cell Biol. 2017 10 02; 216(10):3087-3095.Hinojosa LS, Holst M, … Grosse R
  • Entosis is a nonapoptotic form of cell death initiated by actomyosin-dependent homotypic cell-in-cell invasion that can be observed in malignant exudates during tumor progression. We previously demonstrated formin-mediated actin dynamics at the rear of the invading cell as well as nonapoptotic plasma membrane (PM) blebbing in this cellular motile process. Although the contractile actin cortex inv…
  • Mitosis can drive cell cannibalism through entosis. [Journal Article]
    Elife. 2017 07 11; 6Durgan J, Tseng YY, … Florey O
  • Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which…
  • Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule. [Journal Article]
    Front Physiol. 2017; 8:361.Ahmed N, Yang P, … Chen Q
  • The present study was designed to investigate the hypothesis that in vivo entosis is a novel pathway for eliminating spermatozoa in the seminiferous tubules (ST) during hibernation of the Chinese soft-shelled turtle. Western blot analysis revealed that the expression of LAMP1 in the testis was significantly higher during hibernation than that during non-hibernation. Immunohistochemistry reaction …
  • Cell-in-cell structures are involved in the competition between cells in human tumors. [Journal Article]
    Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1002707.Sun Q, Huang H, Overholtzer M
  • The engulfment of live cells may represent a mechanism of cell death. We reported that E-cadherin (epithelial cadherin) expression in human cancer cells favors the formation of cell-in-cell structures through the mechanism known as entosis, and that entosis contributes to a form of cellular competition in heterogeneous cancer cell populations.
  • Mechanisms and consequences of entosis. [Review]
    Cell Mol Life Sci. 2016 06; 73(11-12):2379-86.Krishna S, Overholtzer M
  • Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell…
  • Stages of Cell Cannibalism--Entosis--in Normal Human Keratinocyte Culture. [Journal Article]
    Biochemistry (Mosc). 2015 Nov; 80(11):1469-77.Garanina AS, Khashba LA, Onishchenko GE
  • Entosis is a type of cell cannibalism during which one cell penetrates into another cell and usually dies inside it. Researchers mainly pay attention to initial and final stages of entosis. Besides, tumor cells in suspension are the primary object of studies. In the present study, we investigated morphological changes of both cells-participants of entosis during this process. The substrate-depend…
  • Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death. [Review]
    Curr Mol Med. 2015; 15(9):861-6.Florey O, Kim SE, Overholtzer M
  • Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is …
  • Foci of Entotic Nuclei in Different Grades of Noninherited Renal Cell Cancers. [Journal Article]
    IUBMB Life. 2015 Feb; 67(2):139-44.Kong Y, Liang Y, Wang J
  • We report here an intriguing pattern in nuclear appearance of renal clear cell cancer. In low grade clear cell cancer, detailed examination showed that in many cells, two or more nuclei were within the confines of a single cell membrane. This likely resulted from a cell being contained within its neighboring cell. Consequently, this resulted in appearance of multicellularity. This appearance of t…
  • V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation. [Journal Article]
    Autophagy. 2015; 11(1):88-99.Florey O, Gammoh N, … Overholtzer M
  • Recently a noncanonical activity of autophagy proteins has been discovered that targets lipidation of microtubule-associated protein 1 light chain 3 (LC3) onto macroendocytic vacuoles, including macropinosomes, phagosomes, and entotic vacuoles. While this pathway is distinct from canonical autophagy, the mechanism of how these nonautophagic membranes are targeted for LC3 lipidation remains unclea…
  • Induction of entosis by epithelial cadherin expression. [Journal Article]
    Cell Res. 2014 Nov; 24(11):1288-98.Sun Q, Cibas ES, … Overholtzer M
  • Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as cell cannibalism. Here we report that the expr…
  • G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. [Journal Article]
    Elife. 2014 Jun 20; 3Purvanov V, Holst M, … Grosse R
  • Homotypic or entotic cell-in-cell invasion is an integrin-independent process observed in carcinoma cells exposed during conditions of low adhesion such as in exudates of malignant disease. Although active cell-in-cell invasion depends on RhoA and actin, the precise mechanism as well as the underlying actin structures and assembly factors driving the process are unknown. Furthermore, whether spec…
  • mTOR regulates phagosome and entotic vacuole fission. [Journal Article]
    Mol Biol Cell. 2013 Dec; 24(23):3736-45.Krajcovic M, Krishna S, … Overholtzer M
  • Macroendocytic vacuoles formed by phagocytosis, or the live-cell engulfment program entosis, undergo sequential steps of maturation, leading to the fusion of lysosomes that digest internalized cargo. After cargo digestion, nutrients must be exported to the cytosol, and vacuole membranes must be processed by mechanisms that remain poorly defined. Here we find that phagosomes and entotic vacuoles u…
  • Methods for the study of entosis. [Journal Article]
    Methods Mol Biol. 2013; 1004:59-66.Sun Q, Overholtzer M
  • Entosis is a recently described nonapoptotic cell death mechanism that is initiated by the engulfment of live epithelial cells, leading to the formation of "cell-in-cell" structures. Entotic cell engulfment is induced by matrix detachment, and is driven by imbalances in actomyosin contraction between neighboring cells. Here we describe methods to quantify the formation of cell-in-cell structures …
  • Silencing the Metallothionein-2A gene induces entosis in adherent MCF-7 breast cancer cells. [Journal Article]
    Anat Rec (Hoboken). 2010 Oct; 293(10):1685-91.Lai Y, Lim D, … Bay BH
  • The presence of a live cell cohabiting within another cell has fascinated scientists for many decades. Far from being a spurious event, many have attempted to uncover the molecular mechanism underlying this phenomenon. In this study, we observed anchorage-dependent MCF-7 cells internalizing neighboring epithelial cells (entosis) after siRNA-mediated silencing of the Metallothionein-2A (MT-2A) gen…
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