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27 results
  • The molecular machinery of regulated cell death. [Review]
    Cell Res 2019; 29(5):347-364Tang D, Kang R, … Kroemer G
  • Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the …
  • Entosis Controls a Developmental Cell Clearance in C. elegans. [Journal Article]
    Cell Rep 2019; 26(12):3212-3220.e4Lee Y, Hamann JC, … Overholtzer M
  • Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to clear the male-specific linker cell in C. elegans. The linker cell leads migration to shape the gonad and is removed to facilitate fus…
  • Methods for the Study of Entotic Cell Death. [Journal Article]
    Methods Mol Biol 2019; 1880:447-454Hamann JC, Kim SE, Overholtzer M
  • Entosis is a mechanism of cell competition occurring in cancers that involves the engulfment and killing of neighboring cells. The death of ingested cells, called entotic cell death, usually occurs in a non-apoptotic, autophagy protein-dependent manner, where microtubule-associated protein light chain 3 (LC3) is lipidated onto entotic vacuoles. Here we present methods to quantify entotic cell dea…
  • Genomic instability in mutant p53 cancer cells upon entotic engulfment. [Journal Article]
    Nat Commun 2018; 9(1):3070Mackay HL, Moore D, … Muller PAJ
  • Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed cells physically interfere in cell divisions of host cells and for cells without p53 this leads to host cell death. In contrast, mutant p53 host cel…
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. [Review]
    Cell Death Differ 2018; 25(3):486-541Galluzzi L, Vitale I, … Kroemer G
  • Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing …
  • Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction. [Journal Article]
    Biochem Biophys Res Commun 2018; 495(1):1440-1446Ruan B, Zhang B, … Sun Q
  • Cell-in-cell structure is prevalent in human cancer, and associated with several specific pathophysiological phenomena. Although cell membrane adhesion molecules were found critical for cell-in-cell formation, the roles of other membrane components, such as lipids, remain to be explored. In this study, we attempted to investigate the effects of cholesterol and phospholipids on the formation of ce…
  • Consecutive entosis stages in human substrate-dependent cultured cells. [Journal Article]
    Sci Rep 2017; 7(1):12555Garanina AS, Kisurina-Evgenieva OP, … Onishchenko GE
  • Entosis, or cell death by invading another cell, is typical for tumor epithelial cells. The formation of cell-in-cell structures is extensively studied in suspension cultures, but remains poorly understood in substrate-dependent cells. Here, we used electron, confocal and time-lapse microscopy in combination with pharmacological inhibition of intracellular components to study the kinetics of ento…
  • MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. [Journal Article]
    J Cell Biol 2017; 216(10):3087-3095Hinojosa LS, Holst M, … Grosse R
  • Entosis is a nonapoptotic form of cell death initiated by actomyosin-dependent homotypic cell-in-cell invasion that can be observed in malignant exudates during tumor progression. We previously demonstrated formin-mediated actin dynamics at the rear of the invading cell as well as nonapoptotic plasma membrane (PM) blebbing in this cellular motile process. Although the contractile actin cortex inv…
  • Mitosis can drive cell cannibalism through entosis. [Journal Article]
    Elife 2017; 6Durgan J, Tseng YY, … Florey O
  • Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which…
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